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Human SARS coronavirus Show undefined attributes

abbreviation COV

created [InstanceEdit:9678121] Orlic-Milacic, Marija, 2020年03月13日

crossReference

[DatabaseIdentifier:9678112] NCBI Taxonomy:694009

dbId 9678119

displayName Human SARS coronavirus

modified [InstanceEdit:9690123] D'Eustachio, Peter, 2020年05月26日

name

Human SARS coronavirus
Severe acute respiratory syndrome-related coronavirus
SARSr-CoV
SARS-CoV-1
HCoV-SARS
Severe acute respiratory syndrome coronavirus

schemaClass Species

superTaxon [Taxon:9678109] Betacoronavirus

taxId 694009

Referrals

(superTaxon)

[Species:9681683] Severe acute respiratory syndrome coronavirus 2

(relatedSpecies)

[Pathway:R-HSA-9678108] SARS-CoV-1 Infection
[Pathway:R-HSA-9692914] SARS-CoV-1-host interactions
[Pathway:R-HSA-9735871] SARS-CoV-1 targets host intracellular signalling and regulatory pathways
[Reaction:R-HSA-9731018] SARS-CoV-1 M binds to PDPK1
[Complex:R-HSA-9731042] PDPK1:M [plasma membrane]
[Reaction:R-HSA-9727919] SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to 14-3-3 proteins
[Complex:R-HSA-9727906] 14-3-3 dimer:SUMO1-K62-p-S177-Ncap dimer [cytosol]
[Reaction:R-HSA-9737710] SARS-CoV-1 N binds SMAD3 and EP300 at the SERPINE1 gene promoter
[Complex:R-HSA-9737684] SARS-CoV-1 N:p-2S-SMAD3:SP1:EP300:SERPINE1 gene [nucleoplasm]
[Complex:R-HSA-9737700] SARS-CoV-1 N:p-2S-SMAD3:SP1:EP300 [nucleoplasm]
[Reaction:R-HSA-9727922] SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to SMAD3
[Complex:R-HSA-9727945] SMAD3:SUMO1-K62-p-S177-Ncap dimer [cytosol]
[Reaction:R-HSA-9727860] SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to UBE2I
[Complex:R-HSA-9727931] UBE2I:SUMO1-K62-p-S177-Ncap dimer [cytosol]
[Reaction:R-HSA-9727908] SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PSMC6
[Complex:R-HSA-9727876] PSMC6:SUMO1-K62-p-S177-Ncap dimer [cytosol]
[Reaction:R-HSA-9727886] SARS-CoV-1 SUMO-p-N binds to NPM1
[Complex:R-HSA-9727894] NPM1:SUMO-p-Ncap [nucleolus]
[Pathway:R-HSA-9735869] SARS-CoV-1 modulates host translation machinery
[Reaction:R-HSA-9727944] SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to EEF1A1
[Complex:R-HSA-9727921] EEF1A1:SUMO1-K62-p-S177-Ncap dimer [cytosol]
[Reaction:R-HSA-9727869] SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to HNRNPA1
[Complex:R-HSA-9727865] HNRNPA1:SUMO1-K62-p-S177-Ncap dimer [cytosol]
[Reaction:R-HSA-9729232] SARS-CoV-1 nsp1 binds to 40S ribosomal subunit
[Complex:R-HSA-9729228] 40S ribosomal complex:nsp1 [cytosol]
[Pathway:R-HSA-9692916] SARS-CoV-1 activates/modulates innate immune responses
[Reaction:R-HSA-9731051] SARS-CoV-1 3b binds to RUNX1
[Complex:R-HSA-9731008] RUNX1:3b [nucleoplasm]
[BlackBoxEvent:R-HSA-9705961] nsp15 cleaves viral poly(U)-RNA
[Reaction:R-HSA-9685162] SARS-CoV-1 M protein interacts with TRAF3
[Complex:R-HSA-9685166] M:K63polyUb-TRAF3 [Golgi membrane]
[Reaction:R-HSA-9706977] 6:KPNA2 binds KPNB1
[Complex:R-HSA-9706975] KPNA2:KPNB1:6 [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-9735840] SARS-CoV-1 7a binds BST2
[Complex:R-HSA-9735861] SARS-CoV-1 7a:BST2 [plasma membrane]
[Reaction:R-HSA-9731047] SARS-CoV-1 6 binds to NMI
[Complex:R-HSA-9731079] NMI:6 [cytosol]
[Reaction:R-HSA-9705959] SARS-CoV-1 6 binds KPNA2
[Complex:R-HSA-9705960] SARS-CoV-1 orf6:KPNA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-9685281] SARS-CoV-1 3a binds TRAF3 within NLRP3 inflammasome
[Complex:R-HSA-9685242] 3a:NLRP3 oligomer:MAVS:TRAF3:PYCARD [mitochondrial outer membrane]
[Reaction:R-HSA-9728804] SARS-CoV-1 nsp1 binds to PPIase
[Complex:R-HSA-9728782] PPIase:nsp1 [cytosol]
[BlackBoxEvent:R-HSA-9685219] SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling)
[Reaction:R-HSA-9756603] SARS-CoV-1 S binds SFTPD 12mer
[Complex:R-HSA-9756585] SFTPD:S3:M:E:encapsidated SARS-CoV-1 genomic RNA: 7a:O-glycosyl 3a tetramer [extracellular region]
[Reaction:R-HSA-9685179] SARS-CoV-1 N protein binds TRIM25
[Complex:R-HSA-9685191] N:TRIM25 [cytosol]
[Reaction:R-HSA-9731057] SARS-CoV-1 3a binds to caspase-1
[Complex:R-HSA-9731024] caspase-1 tetramer:O-glycosyl 3a [plasma membrane]
[Reaction:R-HSA-9728776] SARS-CoV-1 nsp1 binds to RCAN3
[Complex:R-HSA-9728774] RCAN3:nsp1 [cytosol]
[BlackBoxEvent:R-HSA-9685195] SARS-CoV-1 9b recruits ITCH to MAVS
[Complex:R-HSA-9685173] 9b:K48polyUb-MAVS:PCBP2:ITCH [mitochondrial outer membrane]
[Reaction:R-HSA-9710988] SARS-CoV-1 M protein interacts with TBK1/IKBKE
[Complex:R-HSA-9710990] M:TBK1, IKBKE [Golgi membrane]
[Reaction:R-HSA-9685189] SARS-CoV-1 9b binds MAVS and PCBP2
[Complex:R-HSA-9685193] 9b:PCBP2:MAVS [mitochondrial outer membrane]
[Reaction:R-HSA-9731009] SARS-CoV-1 nsp3 binds to IRF3
[Complex:R-HSA-9731036] IRF3:nsp3 [cytosol]
[Reaction:R-HSA-9731072] SARS-CoV-1 3a tetramer induces potassium efflux
[Reaction:R-HSA-9731077] SARS-CoV-1 8b binds to IRF3
[Complex:R-HSA-9731017] IRF3:8b [cytosol]
[Reaction:R-HSA-9731012] SARS-CoV-1 3a tetramerizes
[Complex:R-HSA-9731069] RIPK3:O-glycosyl 3a [plasma membrane]
[Reaction:R-HSA-9709787] SARS-CoV-1 9b binds TOMM70
[Complex:R-HSA-9709728] TOMM70:9b [mitochondrial outer membrane]
[Reaction:R-HSA-9685268] SARS-CoV-1 8b binds NLRP3
[Complex:R-HSA-9685272] 8b:NLRP3 [cytosol]
[BlackBoxEvent:R-HSA-9711058] SARS-CoV-1 nsp3 deubiquinates K48-linked pUb IkBA
[Reaction:R-HSA-9693589] SARS-CoV-1 dsRNA intermediates bind DDX58
[Complex:R-HSA-9704989] SARS-CoV-1 dsRNA intermediates:DDX58:ATP [double membrane vesicle viral factory outer membrane]
[Reaction:R-HSA-9693590] SARS-CoV-1 dsRNA intermediates bind IFIH1:TKFC
[Complex:R-HSA-9693588] SARS-CoV-1 dsRNA intermediates:IFIH1 [double membrane vesicle viral factory outer membrane]
[Reaction:R-HSA-9731031] SARS-CoV-1 6 binds to NPIPB3
[Complex:R-HSA-9731023] NPIPB3:6 [nuclear envelope]
[Reaction:R-HSA-9727857] SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to PKL
[Complex:R-HSA-9727898] PKL:SUMO1-K62-p-S177-Ncap dimer [cytosol]
[Pathway:R-HSA-9692912] SARS-CoV-1 targets PDZ proteins in cell-cell junction
[Pathway:R-HSA-9692913] SARS-CoV-1-mediated effects on programmed cell death
[Reaction:R-HSA-9704655] SARS-CoV-1 E binds BCL2L1
[Complex:R-HSA-9704676] E:BCL2L1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
[BlackBoxEvent:R-HSA-9686338] SARS-CoV-1 3a binds the lysosomal membrane
[Polymerisation:R-HSA-9686336] SARS-CoV-1 3a oligomerizes
[Reaction:R-HSA-9686345] SARS-CoV-1 3a binds RIPK1:RIPK3 oligomer
[Complex:R-HSA-9686348] SARS-CoV-1 3a:(RIPK1:RIPK3) oligomer [cytosol]
[Complex:R-HSA-9692649] 3a tetramer:(RIPK1:RIPK3) oligomer [lysosomal membrane]
[Complex:R-HSA-9686334] 3a tetramer:(RIPK1:RIPK3) oligomer [cytosol]
[Reaction:R-HSA-9704692] SARS-CoV-1 7a binds BCL2L1
[Complex:R-HSA-9704680] 7a:BLC2L1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Pathway:R-HSA-9679509] Virion Assembly and Release
[Pathway:R-HSA-9683701] Translation of Structural Proteins
[Pathway:R-HSA-9679514] SARS-CoV-1 Genome Replication and Transcription
[Pathway:R-HSA-9679504] Translation of Replicase and Assembly of the Replication Transcription Complex
[Pathway:R-HSA-9678110] Attachment and Entry
[Pathway:R-HSA-9683439] Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)
[Reaction:R-HSA-9683429] nsp16 binds nsp10
[Reaction:R-HSA-9682626] nsp13 binds nsp12
[BlackBoxEvent:R-HSA-9687435] Enhanced autophagosome formation
[BlackBoxEvent:R-HSA-9687109] 8b binds MAP1LC3B
[Complex:R-HSA-9687111] 8b:MAP1LC3B [cytosol]
[Pathway:R-HSA-9684325] Maturation of replicase proteins
[BlackBoxEvent:R-HSA-9681596] 3CLp dimer binds ?-Ketoamides
[BlackBoxEvent:R-HSA-9684282] nsp9 forms a homodimer
[Reaction:R-HSA-9684309] 3CLp cleaves nsp6-11
[BlackBoxEvent:R-HSA-9687121] nsp8 binds MAP1LC3B
[Complex:R-HSA-9687117] nsp8:MAP1LC3B [cytosol]
[Pathway:R-HSA-9682708] Transcription of SARS-CoV-1 sgRNAs
[BlackBoxEvent:R-HSA-9685906] Polyadenylation of SARS-CoV-1 subgenomic mRNAs (plus strand)
[Reaction:R-HSA-9684033] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 mRNAs
[BlackBoxEvent:R-HSA-9684016] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 mRNAs
[BlackBoxEvent:R-HSA-9685681] Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs
[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome
[Reaction:R-HSA-9680262] SARS coronavirus gRNA:RTC:RNA primer binds RTC inhibitors
[Reaction:R-HSA-9682631] nsp13 binds DDX5
[Complex:R-HSA-9682634] nsp13:DDX5 [cytosol]
[Reaction:R-HSA-9687388] SARS-CoV-1 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors
[Reaction:R-HSA-9683455] nsp16 binds VHL
[Complex:R-HSA-9683453] nsp16:VHL [cytosol]
[Reaction:R-HSA-9682712] nsp15 binds RB1
[Complex:R-HSA-9682726] nsp15:RB1 [cytosol]
[Reaction:R-HSA-9687384] SARS-CoV-1 gRNA complement (minus strand):RTC binds RTC inhibitors
[Reaction:R-HSA-9682009] ZCRB1 binds 5'UTR of SARS-CoV-1 genomic RNA
[Complex:R-HSA-9682008] ZCRB1:SARS-CoV-1 genomic RNA (plus strand) [cytosol]
[Pathway:R-HSA-9683612] Maturation of protein M
[Pathway:R-HSA-9683673] Maturation of protein 3a
[BlackBoxEvent:R-HSA-9685950] Endocytosis of protein 3a
[Pathway:R-HSA-9683610] Maturation of nucleoprotein
[BlackBoxEvent:R-HSA-9683630] Nucleoprotein translocates to the plasma membrane
[BlackBoxEvent:R-HSA-9683606] Nucleoprotein translocates to the nucleolus
[BlackBoxEvent:R-HSA-9683714] Unphosphorylated nucleoprotein translocates to the plasma membrane
[Pathway:R-HSA-9683686] Maturation of spike protein
[Pathway:R-HSA-9683683] Maturation of protein E
[BlackBoxEvent:R-HSA-9683669] E protein gets N-glycosylated
[BlackBoxEvent:R-HSA-9683635] E pentamer is transported to the Golgi
[Reaction:R-HSA-9683670] Protein E forms a homopentamer
[Pathway:R-HSA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade
[BlackBoxEvent:R-HSA-9711016] SARS-CoV-1 nsp3 deubiquinates K63-linked pUb-STING
[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome
[Pathway:R-HSA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
[BlackBoxEvent:R-HSA-975118] TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex
[Complex:R-HSA-975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane]
[Pathway:R-HSA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
[Reaction:R-HSA-975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
[Reaction:R-HSA-975106] Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
[Reaction:R-HSA-975188] TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation
[Reaction:R-HSA-975111] TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
[Reaction:R-HSA-975125] Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9
[Reaction:R-HSA-975134] Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9
[Reaction:R-HSA-975180] First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
[Complex:R-HSA-975132] IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
[Complex:R-HSA-975130] p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane]
[Complex:R-HSA-975161] pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane]
[Reaction:R-HSA-975160] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9
[Reaction:R-HSA-975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9
[Reaction:R-HSA-975170] IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
[Reaction:R-HSA-975156] IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex
[Reaction:R-HSA-975098] MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88
[Reaction:R-HSA-975175] MyD88 interacts with the activated TLR receptor 7, 8 or 9
[Reaction:R-HSA-167983] C-ter TLR7 dimer binds TLR7, TLR8 ligands
[Complex:R-HSA-9691207] TLR8 dimer:TLR7,TLR8 ligands [endosome membrane]
[Complex:R-HSA-975124] MyD88 complexed with the activated TLR receptor [endosome membrane]
[Complex:R-HSA-975183] IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
[Complex:R-HSA-975113] IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
[Complex:R-HSA-975133] p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane]
[Complex:R-HSA-975146] IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane]
[Complex:R-HSA-975182] TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
[Complex:R-HSA-975178] hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane]
[Complex:R-HSA-975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
[Complex:R-HSA-975148] TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
[Complex:R-HSA-975107] p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
[Complex:R-HSA-975159] p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane]
[Complex:R-HSA-975114] oligo-MyD88:activated TLR7-9 [endosome membrane]
[DefinedSet:R-HSA-975158] Activated TLR7-9 homodimers [endosome membrane]
[Complex:R-HSA-188132] C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane]
[Reaction:R-HSA-9689608] MPP5 binds SARS-CoV-1 E pentamer
[Complex:R-HSA-9689612] MMP5:E pentamer [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Reaction:R-HSA-9731034] SARS-CoV-1 3a tetramer binds to CAV1
[Complex:R-HSA-9731025] CAV1:O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment]
[Reaction:R-HSA-9706720] SARS-CoV-1 E transports Ca2+
[BlackBoxEvent:R-HSA-9685956] 3a is externalized together with membrane structures
[BlackBoxEvent:R-HSA-9685939] 3a localizes to the cell membrane
[BlackBoxEvent:R-HSA-9683679] Ubiquination of protein E
[Reaction:R-HSA-9683720] E protein gets palmitoylated
[BlackBoxEvent:R-HSA-9683656] mRNA4 is translated to protein E
[BlackBoxEvent:R-HSA-9685639] Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching
[BlackBoxEvent:R-HSA-9686005] nsp3 binds to nsp7-8 and nsp12-16
[Reaction:R-HSA-9683393] nsp15 binds nsp8
[Reaction:R-HSA-9682718] nsp15 forms a hexamer
[Reaction:R-HSA-9682258] nsp14 binds nsp12
[Reaction:R-HSA-9680811] nsp12 binds nsp7 and nsp8
[Reaction:R-HSA-9680812] nsp7 binds nsp8
[Reaction:R-HSA-9682544] nsp14 binds nsp10
[BlackBoxEvent:R-HSA-9686013] Nsp3:nsp4 binds to nsp6
[BlackBoxEvent:R-HSA-9686015] Nsp3, nsp4, and nsp6 produce replicative organelles
[BlackBoxEvent:R-HSA-9684261] nsp4 is glycosylated
[Reaction:R-HSA-9684321] nsp3 cleaves nsp1-4
[BlackBoxEvent:R-HSA-9684290] nsp3 is glycosylated
[Reaction:R-HSA-9684352] nsp3-4 cleaves itself
[BlackBoxEvent:R-HSA-9684275] nsp3-4 is glycosylated
[Reaction:R-HSA-9684336] nsp1-4 cleaves itself
[Reaction:R-HSA-9684340] 3CLp cleaves pp1ab
[Reaction:R-HSA-9684273] 3CLp cleaves pp1a
[Reaction:R-HSA-9684323] 3CLp forms a homodimer
[Reaction:R-HSA-9684351] pp1a cleaves itself
[BlackBoxEvent:R-HSA-9684277] mRNA1 is translated to pp1ab
[BlackBoxEvent:R-HSA-9681651] nsp8 generates RNA primers
[BlackBoxEvent:R-HSA-9682695] nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template
[Reaction:R-HSA-9681314] Replication transcription complex binds SARS-CoV-1 genomic RNA
[Reaction:R-HSA-9686709] Uncoating of SARS-CoV-1 Genome
[Reaction:R-HSA-9686699] Fusion and Release of SARS-CoV-1 Nucleocapsid
[Reaction:R-HSA-9686731] TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis
[Reaction:R-HSA-9686710] Cleavage of S protein into S1:S2
[Reaction:R-HSA-9686711] Endocytois of SARS-CoV-1 Virion
[Reaction:R-HSA-9678128] Spike glycoprotein of SARS coronavirus binds ACE2 on host cell
[Reaction:R-HSA-9685542] Viral release
[Reaction:R-HSA-9685531] SARS virus buds into ERGIC lumen
[Reaction:R-HSA-9686174] Accessory proteins are recruited to the maturing virion
[Reaction:R-HSA-9684241] Recruitment of Spike trimer to assembling virion
[Reaction:R-HSA-9684238] E and N are recruited to the M lattice
[Reaction:R-HSA-9684234] Encapsidation of SARS coronavirus genomic RNA
[Reaction:R-HSA-9684229] SUMO-p-N protein dimer binds genomic RNA
[BlackBoxEvent:R-HSA-9685519] Polyadenylation of SARS-CoV-1 genomic RNA (plus strand)
[Reaction:R-HSA-9684032] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)
[BlackBoxEvent:R-HSA-9684017] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)
[BlackBoxEvent:R-HSA-9681840] RTC synthesizes SARS-CoV-1 plus strand genomic RNA
[Reaction:R-HSA-9685597] RTC binds SARS-CoV-1 genomic RNA complement (minus strand)
[Reaction:R-HSA-9684030] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)
[BlackBoxEvent:R-HSA-9684018] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand)
[BlackBoxEvent:R-HSA-9683765] Nucleoprotein translocates to the ERGIC outer membrane
[Reaction:R-HSA-9683634] Dimerisation of nucleoprotein
[BlackBoxEvent:R-HSA-9682465] RTC completes synthesis of the minus strand genomic RNA complement
[Reaction:R-HSA-9682603] nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA
[BlackBoxEvent:R-HSA-9682563] nsp12 misincorporates a nucleotide in nascent RNA minus strand
[BlackBoxEvent:R-HSA-9681674] nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement
[Reaction:R-HSA-9684218] M protein oligomerization
[BlackBoxEvent:R-HSA-9683734] Glycosylated M localizes to the Golgi membrane
[BlackBoxEvent:R-HSA-9683751] M protein gets N-glycosylated
[BlackBoxEvent:R-HSA-9683718] Protein M localizes to the Golgi membrane
[BlackBoxEvent:R-HSA-9683622] mRNA5 is translated to protein M
[BlackBoxEvent:R-HSA-9683648] Spike trimer glycoside chains are extended
[BlackBoxEvent:R-HSA-9683764] Spike trimer translocates to ERGIC
[Reaction:R-HSA-9683719] Spike protein forms a homotrimer
[Reaction:R-HSA-9683653] Spike protein gets palmitoylated
[Reaction:R-HSA-9683772] Trimmed spike protein binds to calnexin
[BlackBoxEvent:R-HSA-9683663] N-glycan trimming of Spike
[BlackBoxEvent:R-HSA-9683755] Spike protein gets N-glycosylated
[BlackBoxEvent:R-HSA-9683624] mRNA2 is translated to Spike
[Reaction:R-HSA-9683746] Protein 3a forms a homotetramer
[Reaction:R-HSA-9683769] O-glycosylation of 3a is terminated
[Reaction:R-HSA-9683760] GalNAc is transferred onto 3a
[BlackBoxEvent:R-HSA-9683712] 3a translocates to the ERGIC
[BlackBoxEvent:R-HSA-9683618] mRNA3 is translated to protein 3a
[Complex:R-HSA-9686311] S3:M:E:encapsidated SARS coronavirus genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [extracellular region]
[Complex:R-HSA-9686692] S3:M:E:encapsidated SARS coronavirus genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [endocytic vesicle lumen]
[BlackBoxEvent:R-HSA-9683735] mRNA9 is translated to Nucleoprotein
[Reaction:R-HSA-9683664] GSK3 phosphorylates Nucleoprotein
[Reaction:R-HSA-9686061] Nucleoprotein is ADP-ribosylated
[Reaction:R-HSA-9683687] Nucleoprotein is SUMOylated
[BlackBoxEvent:R-HSA-9684301] mRNA1 is translated to pp1a
[BlackBoxEvent:R-HSA-9684350] pp1a forms a dimer

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