Reactome Pathway Database

Schema > Reaction > Entries

3CLp cleaves pp1a Show undefined attributes

authored

[InstanceEdit:9683039] Stephan, Ralf, 2020年04月14日

catalystActivity

[CatalystActivity:9684361] cysteine-type endopeptidase activity of 3CLp dimer [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:9684359] Stephan, Ralf, 2020年04月21日

crossReference

[DatabaseIdentifier:11944911] Mondo:0005091

dbId 9684273

disease

[Disease:9678120] severe acute respiratory syndrome

displayName 3CLp cleaves pp1a

edited

[InstanceEdit:9689806] D'Eustachio, Peter, 2020年05月21日

eventOf

[Pathway:R-HSA-9684325] Maturation of replicase proteins - Homo sapiens

followingEvent

input

isChimeric false

isInDisease true

isInferred false

literatureReference

[LiteratureReference:9684297] Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

3CLp cleaves pp1a

output

precedingEvent

[Reaction:R-HSA-9684323] 3CLp forms a homodimer - Homo sapiens

regulatedBy

[NegativeRegulation:9686287] Negative regulation by '3CLp dimer:?-Ketoamides [cytosol]'

relatedSpecies

[Species:9678119] Human SARS coronavirus

releaseDate 2020年06月10日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020年05月27日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9684273

summation

[Summation:9684353] Main protease cleaves all cleavage sites of pp1a and ppa1b s...

Referrals

(precedingEvent)

(hasEvent)

[Pathway:R-HSA-9684325] Maturation of replicase proteins

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