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Entries
Maturation of replicase proteins
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authored
[InstanceEdit:9683039] Stephan, Ralf, 2020年04月14日
created
[InstanceEdit:9684359] Stephan, Ralf, 2020年04月21日
crossReference
[DatabaseIdentifier:11944911] Mondo:0005091
dbId
9684325
disease
[Disease:9678120] severe acute respiratory syndrome
displayName
Maturation of replicase proteins
edited
[InstanceEdit:9689807] D'Eustachio, Peter, 2020年05月21日
eventOf
[Pathway:R-HSA-9679504] Translation of Replicase and Assembly of the Replication Transcription Complex - Homo sapiens
followingEvent
[Pathway:R-HSA-9683439] Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC) - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[BlackBoxEvent:R-HSA-9684350] pp1a forms a dimer - Homo sapiens
[Reaction:R-HSA-9684351] pp1a cleaves itself - Homo sapiens
[Reaction:R-HSA-9684323] 3CLp forms a homodimer - Homo sapiens
[Reaction:R-HSA-9684273] 3CLp cleaves pp1a - Homo sapiens
[Reaction:R-HSA-9684309] 3CLp cleaves nsp6-11 - Homo sapiens
[Reaction:R-HSA-9684340] 3CLp cleaves pp1ab - Homo sapiens
[BlackBoxEvent:R-HSA-9681596] 3CLp dimer binds ?-Ketoamides - Homo sapiens
[Reaction:R-HSA-9684336] nsp1-4 cleaves itself - Homo sapiens
[BlackBoxEvent:R-HSA-9684275] nsp3-4 is glycosylated - Homo sapiens
[Reaction:R-HSA-9684352] nsp3-4 cleaves itself - Homo sapiens
[BlackBoxEvent:R-HSA-9684290] nsp3 is glycosylated - Homo sapiens
[Reaction:R-HSA-9684321] nsp3 cleaves nsp1-4 - Homo sapiens
[BlackBoxEvent:R-HSA-9684261] nsp4 is glycosylated - Homo sapiens
[BlackBoxEvent:R-HSA-9684282] nsp9 forms a homodimer - Homo sapiens
isInDisease
true
isInferred
false
lastUpdatedDate
2021年09月15日
literatureReference
[LiteratureReference:9684331] SARS-CoV 3CL protease cleaves its C-terminal autoprocessing site by novel subsite cooperativity
[LiteratureReference:9684306] Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity
[LiteratureReference:9684300] Localization and membrane topology of coronavirus nonstructural protein 4: involvement of the early secretory pathway in replication
maxDepth
2
modified
[InstanceEdit:9847082] Weiser, Joel, 2023年10月12日
name
Maturation of replicase proteins
orthologousEvent
[Pathway:R-HSA-9694301] Maturation of replicase proteins - Homo sapiens
precedingEvent
[BlackBoxEvent:R-HSA-9684301] mRNA1 is translated to pp1a - Homo sapiens
[BlackBoxEvent:R-HSA-9684277] mRNA1 is translated to pp1ab - Homo sapiens
relatedSpecies
[Species:9678119] Human SARS coronavirus
releaseDate
2020年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020年05月27日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9684325
summation
[Summation:9684318] Production of polyprotein fragments (so called replicase pro...
updateTrackers
[UpdateTracker:9775519] Update Tracker - [Pathway:9684325] Maturation of replicase proteins - v78:[updateContainedRLE]
[UpdateTracker:9776839] Update Tracker - [Pathway:9684325] Maturation of replicase proteins - v74:[updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9775519] Update Tracker - [Pathway:9684325] Maturation of replicase proteins - v78:[updateContainedRLE]
[UpdateTracker:9776839] Update Tracker - [Pathway:9684325] Maturation of replicase proteins - v74:[updateContainedRLE]
(precedingEvent)
[Pathway:R-HSA-9683439] Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)
(hasEvent)
[Pathway:R-HSA-9679504] Translation of Replicase and Assembly of the Replication Transcription Complex
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