Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
Show undefined attributes
Go to Details
authored
[InstanceEdit:937084] Shamovsky, V, 2010年08月25日
category
binding
compartment
[Compartment:74700] endosome membrane
[Compartment:70101] cytosol
created
[InstanceEdit:975168] Shamovsky, V, 2010年09月22日
dbId
975111
displayName
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
edited
[InstanceEdit:1014292] Shamovsky, V, 2010年11月15日
eventOf
[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome - Homo sapiens
followingEvent
[Reaction:R-HSA-975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex - Homo sapiens
[Reaction:R-HSA-975188] TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation - Homo sapiens
input
[Complex:R-HSA-975178] hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane]
4 ×
[EntityWithAccessionedSequence:R-HSA-166366] TRAF6 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:450115] TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB
[LiteratureReference:446876] TRAF6 is a signal transducer for interleukin-1
[LiteratureReference:165903] Identification of threonine 66 as a functionally critical residue of the
[LiteratureReference:450151] Distinct molecular mechanism for initiating TRAF6 signalling
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
orthologousEvent
[Reaction:R-GGA-532632] TRAF6 binds to p-IRAK2 complexed with activated TLR7 or TLR21 - Gallus gallus
output
[Complex:R-HSA-975182] TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
precedingEvent
[Reaction:R-HSA-975125] Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 - Homo sapiens
[Reaction:R-HSA-975160] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 - Homo sapiens
relatedSpecies
[Species:9678119] Human SARS coronavirus
[Species:164493] Human immunodeficiency virus 1
[Species:9031716] Influenza A virus
[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:983288] Gillespie, ME, 2010年10月29日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-975111
summation
[Summation:446863] Hyperphosphorylated IRAK1, still within the receptor complex...
[Summation:937037] IRAK-2 has two TRAF6 binding motifs that are responsible for...
updateTrackers
[UpdateTracker:9788617] Update Tracker - [Reaction:975111] TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 - v41:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9788617] Update Tracker - [Reaction:975111] TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 - v41:[modifyText]
(hasEvent)
[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome
(precedingEvent)
[Reaction:R-HSA-975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
[Reaction:R-HSA-975188] TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル