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MyD88 dependent cascade initiated on endosome
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authored
[InstanceEdit:166017] de Bono, B, 2005年08月16日 10:54:15
compartment
[Compartment:70101] cytosol
[Compartment:74700] endosome membrane
[Compartment:7660] nucleoplasm
created
[InstanceEdit:975168] Shamovsky, V, 2010年09月22日
crossReference
[DatabaseIdentifier:12757928] BioModels Database:BIOMD0000000477
dbId
975155
displayName
MyD88 dependent cascade initiated on endosome
edited
[InstanceEdit:1014278] Shamovsky, V, 2010年11月15日
eventOf
[Pathway:R-HSA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade - Homo sapiens
[Pathway:R-HSA-168138] Toll Like Receptor 9 (TLR9) Cascade - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-975175] MyD88 interacts with the activated TLR receptor 7, 8 or 9 - Homo sapiens
[Reaction:R-HSA-975098] MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 - Homo sapiens
[Reaction:R-HSA-975156] IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex - Homo sapiens
[Reaction:R-HSA-975170] IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 - Homo sapiens
[Reaction:R-HSA-975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9 - Homo sapiens
[Reaction:R-HSA-975160] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 - Homo sapiens
[Reaction:R-HSA-975180] First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 - Homo sapiens
[Reaction:R-HSA-975134] Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 - Homo sapiens
[Reaction:R-HSA-975125] Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 - Homo sapiens
[Reaction:R-HSA-975111] TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 - Homo sapiens
[Pathway:R-HSA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Homo sapiens
[Pathway:R-HSA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2022年06月09日
literatureReference
[LiteratureReference:2445228] Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance
[LiteratureReference:165842] MD-2: the Toll 'gatekeeper' in endotoxin signalling
[LiteratureReference:2445170] Comparison of human B cell activation by TLR7 and TLR9 agonists
maxDepth
7
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
MyD88 dependent cascade initiated on endosome
orthologousEvent
[Pathway:R-MMU-975155] MyD88 dependent cascade initiated on endosome - Mus musculus
[Pathway:R-CFA-975155] MyD88 dependent cascade initiated on endosome - Canis familiaris
[Pathway:R-BTA-975155] MyD88 dependent cascade initiated on endosome - Bos taurus
[Pathway:R-SSC-975155] MyD88 dependent cascade initiated on endosome - Sus scrofa
[Pathway:R-DRE-975155] MyD88 dependent cascade initiated on endosome - Danio rerio
[Pathway:R-XTR-975155] MyD88 dependent cascade initiated on endosome - Xenopus tropicalis
[Pathway:R-GGA-975155] MyD88 dependent cascade initiated on endosome - Gallus gallus
[Pathway:R-DME-975155] MyD88 dependent cascade initiated on endosome - Drosophila melanogaster
[Pathway:R-CEL-975155] MyD88 dependent cascade initiated on endosome - Caenorhabditis elegans
[Pathway:R-DDI-975155] MyD88 dependent cascade initiated on endosome - Dictyostelium discoideum
[Pathway:R-SPO-975155] MyD88 dependent cascade initiated on endosome - Schizosaccharomyces pombe
[Pathway:R-SCE-975155] MyD88 dependent cascade initiated on endosome - Saccharomyces cerevisiae
[Pathway:R-PFA-975155] MyD88 dependent cascade initiated on endosome - Plasmodium falciparum
[Pathway:R-RNO-975155] MyD88 dependent cascade initiated on endosome - Rattus norvegicus
relatedSpecies
[Species:9678119] Human SARS coronavirus
[Species:164493] Human immunodeficiency virus 1
[Species:9031716] Influenza A virus
[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:983288] Gillespie, ME, 2010年10月29日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-975155
summation
[Summation:975135] Upon binding of their ligands, TLR7/8 and TLR9 recruit a cyt...
updateTrackers
[UpdateTracker:9782590] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v59:[updateContainedRLE]
[UpdateTracker:9784325] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v54:[updateContainedPathway]
[UpdateTracker:9788542] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v41:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9779505] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v65:[updateIndirectRLE]
[UpdateTracker:9784957] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v52:[updateContainedPathway]
[UpdateTracker:9789522] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v38:[updateContainedPathway]
[UpdateTracker:9788493] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v42:[addLiteratureReference, updateContainedPathway, updateContainedRLE]
[UpdateTracker:9774651] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v81:[updateContainedPathway]
[UpdateTracker:9775171] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v80:[updateContainedPathway]
[UpdateTracker:9788146] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v43:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9778642] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v68:[updateContainedPathway]
[UpdateTracker:9789815] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v37:[updateContainedRLE]
[UpdateTracker:9787797] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v44:[updateIndirectRLE]
[UpdateTracker:9784700] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v53:[updateContainedPathway]
Referrals
(hasEvent)
[Pathway:R-HSA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade
[Pathway:R-HSA-168138] Toll Like Receptor 9 (TLR9) Cascade
(hasEncapsulatedEvent)
[Pathway:R-HSA-5686938] Regulation of TLR by endogenous ligand
[Pathway:R-HSA-9705683] SARS-CoV-2-host interactions
[Pathway:R-HSA-9692914] SARS-CoV-1-host interactions
(updatedInstance)
[UpdateTracker:9782590] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v59:[updateContainedRLE]
[UpdateTracker:9784325] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v54:[updateContainedPathway]
[UpdateTracker:9788542] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v41:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9779505] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v65:[updateIndirectRLE]
[UpdateTracker:9784957] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v52:[updateContainedPathway]
[UpdateTracker:9789522] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v38:[updateContainedPathway]
[UpdateTracker:9788493] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v42:[addLiteratureReference, updateContainedPathway, updateContainedRLE]
[UpdateTracker:9774651] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v81:[updateContainedPathway]
[UpdateTracker:9775171] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v80:[updateContainedPathway]
[UpdateTracker:9788146] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v43:[updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9778642] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v68:[updateContainedPathway]
[UpdateTracker:9789815] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v37:[updateContainedRLE]
[UpdateTracker:9787797] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v44:[updateIndirectRLE]
[UpdateTracker:9784700] Update Tracker - [Pathway:975155] MyD88 dependent cascade initiated on endosome - v53:[updateContainedPathway]
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