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Schema
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Reaction
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Entries
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex
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authored
[InstanceEdit:937084] Shamovsky, V, 2010年08月25日
category
binding
compartment
[Compartment:74700] endosome membrane
[Compartment:70101] cytosol
created
[InstanceEdit:975168] Shamovsky, V, 2010年09月22日
dbId
975156
displayName
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex
edited
[InstanceEdit:1014262] Shamovsky, V, 2010年11月15日
eventOf
[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome - Homo sapiens
followingEvent
[Reaction:R-HSA-975170] IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 - Homo sapiens
input
4 ×
[EntityWithAccessionedSequence:R-HSA-166081] IRAK4 [cytosol]
[Complex:R-HSA-975114] oligo-MyD88:activated TLR7-9 [endosome membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:165864] IRAK-4 as the central TIR signaling mediator in innate immunity
[LiteratureReference:165891] IRAK-4: a novel member of the IRAK family with the properties of an
[LiteratureReference:2428829] Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses
[LiteratureReference:2445219] The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex
orthologousEvent
[Reaction:R-GGA-451461] IRAK4 binds to the activated TLR7 or 21 - Gallus gallus
output
[Complex:R-HSA-975183] IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
precedingEvent
[Reaction:R-HSA-975098] MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 - Homo sapiens
relatedSpecies
[Species:9678119] Human SARS coronavirus
[Species:164493] Human immunodeficiency virus 1
[Species:9031716] Influenza A virus
[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:983288] Gillespie, ME, 2010年10月29日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-975156
summation
[Summation:169747] IRAK4 is the mammalian homolog of Drosophila melanogaster Tu...
updateTrackers
[UpdateTracker:9788447] Update Tracker - [Reaction:975156] IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex - v42:[addLiteratureReference]
[UpdateTracker:9788238] Update Tracker - [Reaction:975156] IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex - v43:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9788447] Update Tracker - [Reaction:975156] IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex - v42:[addLiteratureReference]
[UpdateTracker:9788238] Update Tracker - [Reaction:975156] IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex - v43:[modifyText]
(hasEvent)
[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome
(precedingEvent)
[Reaction:R-HSA-975170] IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
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