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Schema
>
Species
>
Entries
Human immunodeficiency virus 1
Show undefined attributes
abbreviation
HIV
created
[InstanceEdit:164494] D'Eustachio, P, 2005年05月23日 14:55:21
crossReference
[DatabaseIdentifier:164488] NCBI_taxonomy:11676
dbId
164493
displayName
Human immunodeficiency virus 1
modified
[InstanceEdit:9014479] Weiser, JD
name
Human immunodeficiency virus 1
Human immunodeficiency virus type 1
HIV1
HIV-1
Human immunodeficiency virus type 1 (isolate 90CF056 group M subtype H)
Human immunodeficiency virus type 1 (isolate 92BR025 group M subtype C)
Human immunodeficiency virus type 1 (isolate 92NG083 group M subtype G)
Human immunodeficiency virus type 1 (isolate 93BR020 group M subtype F1)
Human immunodeficiency virus type 1 (isolate 96CM-MP535 group M subtype K)
Human immunodeficiency virus type 1 (isolate 97ZR-EQTB11 group M subtype K)
Human immunodeficiency virus type 1 (isolate ANT70 group O)
Human immunodeficiency virus type 1 (isolate ARV2/SF2 group M subtype B)
Human immunodeficiency virus type 1 (isolate BH10 group M subtype B)
Human immunodeficiency virus type 1 (isolate BH5 group M subtype B)
Human immunodeficiency virus type 1 (isolate BH8 group M subtype B)
Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B)
Human immunodeficiency virus type 1 (isolate BRVA group M subtype B)
Human immunodeficiency virus type 1 (isolate CDC-451 group M subtype B)
Human immunodeficiency virus type 1 (isolate ELI group M subtype D)
Human immunodeficiency virus type 1 (isolate ETH2220 group M subtype C)
Human immunodeficiency virus type 1 (isolate HXB2 group M subtype B)
Human immunodeficiency virus type 1 (isolate HXB3 group M subtype B)
Human immunodeficiency virus type 1 (isolate JH32 group M subtype B)
Human immunodeficiency virus type 1 (isolate JRCSF group M subtype B)
Human immunodeficiency virus type 1 (isolate KB-1/ETR group M subtype B)
Human immunodeficiency virus type 1 (isolate Lai group M subtype B)
Human immunodeficiency virus type 1 (isolate LW123 group M subtype B)
Human immunodeficiency virus type 1 (isolate MAL group M subtype A)
Human immunodeficiency virus type 1 (isolate MFA group M subtype B)
Human immunodeficiency virus type 1 (isolate MN group M subtype B)
Human immunodeficiency virus type 1 (isolate MP255 group M subtype F2)
Human immunodeficiency virus type 1 (isolate MP257 group M subtype F2)
Human immunodeficiency virus type 1 (isolate MVP5180 group O)
Human immunodeficiency virus type 1 (isolate N1T-A group M subtype B)
Human immunodeficiency virus type 1 (isolate NDK group M subtype D)
Human immunodeficiency virus type 1 (isolate NY5 group M subtype B)
Human immunodeficiency virus type 1 (isolate OYI group M subtype B)
Human immunodeficiency virus type 1 (isolate PCV12 group M subtype B)
Human immunodeficiency virus type 1 (isolate RF/HAT3 group M subtype B)
Human immunodeficiency virus type 1 (isolate SC group M subtype B)
Human immunodeficiency virus type 1 (isolate SE6165 group M subtype G)
Human immunodeficiency virus type 1 (isolate SE9173 group M subtype J)
Human immunodeficiency virus type 1 (isolate SE9280 group M subtype J)
Human immunodeficiency virus type 1 (isolate SF162 group M subtype B)
Human immunodeficiency virus type 1 (isolate SF33 group M subtype B)
Human immunodeficiency virus type 1 (isolate U455 group M subtype A)
Human immunodeficiency virus type 1 (isolate VI850 group M subtype F1)
Human immunodeficiency virus type 1 (isolate VI991 group M subtype H)
Human immunodeficiency virus type 1 (isolate WMJ1 group M subtype B)
Human immunodeficiency virus type 1 (isolate WMJ22 group M subtype B)
Human immunodeficiency virus type 1 (isolate YBF106 group N)
Human immunodeficiency virus type 1 (isolate YBF30 group N)
Human immunodeficiency virus type 1 (isolate YU-2 group M subtype B)
Human immunodeficiency virus type 1 (isolate Z2/CDC-Z34 group M subtype D)
Human immunodeficiency virus type 1 (isolate Z3 group M subtype U)
Human immunodeficiency virus type 1 (isolate Z321 group M subtype A)
Human immunodeficiency virus type 1 (isolate Z6 group M subtype D)
Human immunodeficiency virus type 1 (isolate Z84 group M subtype D)
Human immunodeficiency virus type 1 (strain 89.6 group M subtype B)
schemaClass
Species
superTaxon
[Taxon:164490] Primate lentivirus group
taxId
11676
Referrals
(relatedSpecies)
[Pathway:R-HSA-5663205] Infectious disease
[Pathway:R-HSA-162906] HIV Infection
[Pathway:R-HSA-162587] HIV Life Cycle
[Pathway:R-HSA-162599] Late Phase of HIV Life Cycle
[Pathway:R-HSA-162588] Budding and maturation of HIV virion
[Reaction:R-HSA-3139027] Maturation of HIV Virion
[BlackBoxEvent:R-HSA-3159227] HIV Virion Budding
[Complex:R-HSA-3139025] Immature HIV virion [extracellular region]
[Complex:R-HSA-3597666] monoubiquitinated N-myristoyl GAG (P04591) protein [extracellular region]
[Reaction:R-HSA-9697043] Protease binds protease inhibitors
[Reaction:R-HSA-3159232] Recruitment Of HIV Virion Budding Machinery
[Pathway:R-HSA-175474] Assembly Of The HIV Virion
[Reaction:R-HSA-3149454] Packaging of HIV virion on the host cell plasma membrane
[Complex:R-HSA-3149451] Assembling HIV virion [plasma membrane]
[Pathway:R-HSA-174495] Synthesis And Processing Of GAG, GAGPOL Polyproteins
[BlackBoxEvent:R-HSA-187213] Synthesis of GAG polyprotein
[Pathway:R-HSA-174490] Membrane binding and targetting of GAG proteins
[Reaction:R-HSA-3149434] Transport of GAG to the Plasma Membrane
[Reaction:R-HSA-184269] Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex
[Complex:R-HSA-3149449] monoubiquitinated N-myristoyl GAG (P04591) protein [plasma membrane]
[Complex:R-HSA-184475] monoubiquitinated N-myristoyl GAG (P04591) protein [endosome membrane]
[BlackBoxEvent:R-HSA-184323] Monoubiquitination of N-myristoyl GAG polyprotein
[Reaction:R-HSA-184392] N-myristoylation of GAG polyprotein by NMT2
[Complex:R-HSA-184369] monoubiquitinated N-myristoyl GAG (P04591) protein [cytosol]
[Pathway:R-HSA-171286] Synthesis and processing of ENV and VPU
[Reaction:R-HSA-173647] Transport of trimeric gp41:gp120 to plasma membrane
[Reaction:R-HSA-171288] Cleavage of the viral Env gp160 precursor polyprotein
[Reaction:R-HSA-174491] Transport of trimeric ENV precursor to Golgi apparatus
[Reaction:R-HSA-171291] Folding and Oligomerization of ENV glycoprotein
[Reaction:R-HSA-174493] Glycosylation of ENV polyprotein
[BlackBoxEvent:R-HSA-174494] Synthesis of ENV polyprotein
[Reaction:R-HSA-3149432] Transport of VPU to Plasma Membrane
[Reaction:R-HSA-3149440] Transport of VPU to Golgi apparatus
[BlackBoxEvent:R-HSA-3149433] Synthesis of VPU protein
[BlackBoxEvent:R-HSA-187211] Splicing of HIV RNA transcript
[Reaction:R-HSA-162914] Myristoylation of Nef
[Pathway:R-HSA-162594] Early Phase of HIV Life Cycle
[Pathway:R-HSA-162585] Uncoating of the HIV Virion
[Pathway:R-HSA-162592] Integration of provirus
[Pathway:R-HSA-162589] Reverse Transcription of HIV RNA
[Pathway:R-HSA-164525] Plus-strand DNA synthesis
[Pathway:R-HSA-164516] Minus-strand DNA synthesis
[Reaction:R-HSA-9697051] RTC binds NRTIs
[Reaction:R-HSA-175117] 1-LTR circle formation
[Pathway:R-HSA-175567] Integration of viral DNA into host genomic DNA
[Reaction:R-HSA-164506] Gap repair completes provirus integration
[Reaction:R-HSA-164523] Transesterification to connect viral DNA 3' ends to host DNA 5' ends
[Complex:R-HSA-175148] Integration intermediate [nucleoplasm]
[Complex:R-HSA-175339] IN:viral DNA bound to host genomic DNA [nucleoplasm]
[Reaction:R-HSA-175108] Target DNA binding
[Complex:R-HSA-175224] IN:viral DNA bound to host genomic DNA with staggered ends [nucleoplasm]
[Pathway:R-HSA-164843] 2-LTR circle formation
[Reaction:R-HSA-175258] 2-LTR formation due to circularization of viral DNA
[Reaction:R-HSA-175177] Association of XRCC4:DNA ligase IV complex with viral DNA ends
[Complex:R-HSA-175440] viral DNA:Ku proteins:XRCC4:DNA ligase IV complex [nucleoplasm]
[Reaction:R-HSA-175174] Association of Ku heterodimer with viral DNA ends
[Complex:R-HSA-175247] Ku proteins bound to viral DNA [nucleoplasm]
[Pathway:R-HSA-177539] Autointegration results in viral DNA circles
[Reaction:R-HSA-164845] Suicidal integration leading to inverted circle formation
[Reaction:R-HSA-175250] Suicidal integration leading to smaller circles of viral DNA
[Reaction:R-HSA-162590] Import of PIC to the Host Nucleus
[Reaction:R-HSA-164522] Terminal (3' end) cleavage of viral DNA
[Complex:R-HSA-177527] viral PIC proteins [nucleoplasm]
[Complex:R-HSA-175416] IN bound to sticky 3' ends of viral DNA in PIC [nucleoplasm]
[Reaction:R-HSA-164514] Integrase binds viral DNA ends
[Reaction:R-HSA-173115] Formation of Pre-Integration Complex (PIC)
[Reaction:R-HSA-8951690] Formation of RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1
[Reaction:R-HSA-182876] Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA
[Reaction:R-HSA-164505] Synthesis of full-length duplex viral DNA with a discontinuous plus strand
[Reaction:R-HSA-164512] Second strand transfer by annealing complementary PBS sequences
[Reaction:R-HSA-173769] RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers
[Reaction:R-HSA-164513] 3' PPT-primed initiation of plus-strand DNA synthesis
[Reaction:R-HSA-182795] RNase H-mediated degradation of the template strand
[Reaction:R-HSA-164528] RNase H-mediated cleavage of the template strand
[Reaction:R-HSA-164520] Minus strand DNA synthesis resumes
[Reaction:R-HSA-164503] First strand transfer mediated by Repeated (R) sequence
[Reaction:R-HSA-182859] RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex
[Reaction:R-HSA-164519] RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex
[Reaction:R-HSA-164504] Synthesis of minus strand strong stop DNA (-sssDNA)
[Reaction:R-HSA-164527] Annealing of 3'-end of unwound transfer RNA primer with genomic RNA
[Reaction:R-HSA-173771] Formation of RTC (Reverse Transcription Complex)
[Reaction:R-HSA-173111] Disassembly of viral capsid
[Depolymerisation:R-HSA-173642] Disintegration of matrix layer
[Complex:R-HSA-188943] Encapsidated viral core [cytosol]
[Complex:R-HSA-173653] uncoated viral complex [cytosol]
[Complex:R-HSA-173814] RTC (Reverse Transcription Complex) with RNA template [cytosol]
[Complex:R-HSA-9680894] RTC:NRTIs [cytosol]
[Complex:R-HSA-173801] RTC with tRNA primer:RNA template [cytosol]
[Complex:R-HSA-182804] RTC with nicked minus sssDNA:tRNA primer:RNA template [cytosol]
[Complex:R-HSA-182864] nicked minus sssDNA:RNA template:tRNA primer [cytosol]
[Complex:R-HSA-173773] RTC with degraded RNA template and minus sssDNA [cytosol]
[Complex:R-HSA-173825] minus sssDNA:tRNA primer generated by RNAse-H [cytosol]
[Complex:R-HSA-173779] RTC with minus sssDNA transferred to 3'-end of viral RNA template [cytosol]
[Complex:R-HSA-173786] RTC with minus strand DNA synthesis initiated from 3'-end [cytosol]
[Complex:R-HSA-173784] minus sssDNA primer transferred to 3'- end of viral RNA template [cytosol]
[Complex:R-HSA-173789] RTC with extensive RNase-H digestion [cytosol]
[Complex:R-HSA-173764] RTC with extending minus strand DNA [cytosol]
[Complex:R-HSA-182880] RTC with extending second-strand DNA [cytosol]
[Complex:R-HSA-173824] RTC without viral RNA template [cytosol]
[Complex:R-HSA-173766] minus sssDNA primer for minus strand DNA extension [cytosol]
[Complex:R-HSA-173792] RTC with annealed complementary PBS seqments in +sssDNA and -strand DNA [cytosol]
[Complex:R-HSA-188560] RTC with duplex DNA containing discontinuous plus strand flap [cytosol]
[Complex:R-HSA-9608475] RTC with integration competent viral DNA:BANF1:HMGA1:PSIP1 [cytosol]
[Complex:R-HSA-175254] RTC with integration competent viral DNA [cytosol]
[Complex:R-HSA-177532] viral DNA bound with Integrase in PIC [cytosol]
[Complex:R-HSA-175143] PIC (PreIntegration Complex) [cytosol]
[Pathway:R-HSA-173107] Binding and entry of HIV virion
[Reaction:R-HSA-164524] Fusion of viral membrane with host cell membrane
[Complex:R-HSA-173664] Viral core surrounded by Matrix layer [cytosol]
[Reaction:R-HSA-164508] N and C terminal heptad repeat helices of gp41 form six-helix bundle
[Complex:R-HSA-173649] Virion with gp41 forming hairpin structure [extracellular region]
[Complex:R-HSA-171297] CD4:Env gp120/gp41 hairpin complex:CCR5/CXCR4 [plasma membrane]
[Complex:R-HSA-171294] CD4:Env gp120/gp41 hairpin complex [plasma membrane]
[Reaction:R-HSA-164521] Insertion of gp41 fusion peptide into the target membrane
[Complex:R-HSA-173656] Virion with gp41 fusion peptide in insertion complex [extracellular region]
[Complex:R-HSA-171285] CD4:Env gp120/gp41insertion complex:CCR5/CXCR4 [plasma membrane]
[Complex:R-HSA-171276] CD4:Env gp120/gp41 insertion complex [plasma membrane]
[Reaction:R-HSA-164515] Fusogenic activation of gp41
[Reaction:R-HSA-164500] Conformational changes in gp120 exposes gp41
[Reaction:R-HSA-164507] CD4:gp120 binds to chemokine co-receptor CCR5/CXCR4
[Reaction:R-HSA-164510] Conformational change in gp120 of Env oligomer
[Reaction:R-HSA-164509] Binding of gp120 of ENV oligomer to the host CD4
[Complex:R-HSA-175514] Mature HIV virion [extracellular region]
[Complex:R-HSA-173650] Virion with CD4 bound to gp120 [extracellular region]
[Complex:R-HSA-171281] CD4:gp120:gp41 membrane complex [plasma membrane]
[Complex:R-HSA-173648] Virion with exposed coreceptor binding sites [extracellular region]
[Complex:R-HSA-173663] Virion with CD4:gp120 bound to CCR5/CXCR4 [extracellular region]
[Complex:R-HSA-171278] CD4:Env gp120:CCR5,CXCR4:complex [plasma membrane]
[Complex:R-HSA-171289] CD4:Env gp120 with exposed coreceptor binding site [plasma membrane]
[Complex:R-HSA-173639] Virion with fusogenically activated gp41 [extracellular region]
[Complex:R-HSA-171284] CD4:Env gp120/gp41 fusion peptide complex:CCR5 [plasma membrane]
[Complex:R-HSA-171280] CD4:Env gp120/gp41 fusion peptide complex [plasma membrane]
[Complex:R-HSA-173665] Virion with gp41 exposed [extracellular region]
[Complex:R-HSA-171293] CCR5/CXCR4:CD4:Env gp120 (second conformation change) complex [plasma membrane]
[Complex:R-HSA-171298] CD4:Env gp120 (second conformation change) complex [plasma membrane]
[Pathway:R-HSA-162909] Host Interactions of HIV factors
[Pathway:R-HSA-180585] Vif-mediated degradation of APOBEC3G
[BlackBoxEvent:R-HSA-180603] Proteosome-mediated degradation of APOBEC3G
[Reaction:R-HSA-180540] Multi-ubiquitination of APOBEC3G
[Complex:R-HSA-180539] Vif:Cul5:SCF complex [cytosol]
[Complex:R-HSA-180577] multi-ubiquitinated APOBEC3G:Vif:Cul5:SCF complex [cytosol]
[Reaction:R-HSA-180555] Association of APOBEC3G:Vif with the Cul5-SCF complex
[Complex:R-HSA-180549] APOBEC3G:Vif:Cul5:SCF complex [cytosol]
[Reaction:R-HSA-180602] Association of Vif with APOBEC3G
[Pathway:R-HSA-164952] The role of Nef in HIV-1 replication and disease pathogenesis
[Pathway:R-HSA-164938] Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
[Pathway:R-HSA-164940] Nef mediated downregulation of MHC class I complex cell surface expression
[BlackBoxEvent:R-HSA-182263] Degradation of MHC I Complex
[Reaction:R-HSA-182286] Transport of MHC I:Nef:AP-1:PACS-1 Complex
[Complex:R-HSA-182254] Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane]
[Reaction:R-HSA-182279] Formation of MHC I:Nef:AP-1:PACS-1 Complex
[Complex:R-HSA-182373] Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane]
[Reaction:R-HSA-182243] Formation of MHC I:Nef Complex
[Complex:R-HSA-182256] Nef:class I MHC complex [Golgi membrane]
[Pathway:R-HSA-164939] Nef mediated downregulation of CD28 cell surface expression
[Reaction:R-HSA-167637] Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex
[Complex:R-HSA-167631] CD28:Nef:Clathrin-coated Pit Adapter Protein [cytosol]
[Reaction:R-HSA-167633] Formation of Nef:Cd28:Clathrin-coated Pit Adapter Protein complex
[Reaction:R-HSA-167630] Formation of Nef CD28 cytoplasmic tail complex
[Complex:R-HSA-167636] CD28:Nef:Clathrin-coated Pit Adapter Protein Complex [plasma membrane]
[Complex:R-HSA-167629] Nef:CD28 Complex [plasma membrane]
[Pathway:R-HSA-182218] Nef Mediated CD8 Down-regulation
[BlackBoxEvent:R-HSA-182171] Degradation of CD8
[Reaction:R-HSA-182198] Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex
[Reaction:R-HSA-182186] Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex
[Complex:R-HSA-182230] Internalized CD8:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane]
[Complex:R-HSA-182158] CD8:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane]
[Complex:R-HSA-182194] CD8:Nef Complex [plasma membrane]
[Pathway:R-HSA-167590] Nef Mediated CD4 Down-regulation
[BlackBoxEvent:R-HSA-167601] Degradation of CD4
[Reaction:R-HSA-167597] Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex
[Reaction:R-HSA-200879] Formation of a Nef:ARF1:CD4 complex
[Complex:R-HSA-200867] Arf1:Nef:endosomal CD4 [early endosome membrane]
[Complex:R-HSA-167554] Internalized CD4:Nef:Clathrin-Coated Pit Adapter Protein:v-ATPase [early endosome membrane]
[Reaction:R-HSA-167537] Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex
[Reaction:R-HSA-167566] Nef mediated disruption of CD4:Lck Complex
[Complex:R-HSA-167544] CD4:Nef:AP-2 Complex:v-ATPase Complex [plasma membrane]
[Complex:R-HSA-167596] CD4:Nef Complex [plasma membrane]
[Pathway:R-HSA-164944] Nef and signal transduction
[Reaction:R-HSA-200908] Nef Binds and activates the Src-family tyrosine kinase Fyn
[Complex:R-HSA-200911] Fyn:Nef Complex [cytosol]
[Reaction:R-HSA-164943] Nef mediated activation of the T-cell receptor
[Complex:R-HSA-167576] Nef:T cell Receptor zeta:Lipid Raft: Pak 2 Complex [plasma membrane]
[Reaction:R-HSA-200952] Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction
[Complex:R-HSA-200937] DOCK2:ELMO1:RAC1:Nef Complex [cytosol]
[Reaction:R-HSA-200954] Nef Binds and activates the Src-family tyrosine kinase Lck
[Complex:R-HSA-200922] Lck:Nef [cytosol]
[Reaction:R-HSA-200858] Nef Binds and activates the Src-family tyrosine kinase Hck
[Complex:R-HSA-200872] Hck-1:Nef [cytosol]
[Pathway:R-HSA-177243] Interactions of Rev with host cellular proteins
[Pathway:R-HSA-165054] Rev-mediated nuclear export of HIV RNA
[Pathway:R-HSA-167172] Transcription of the HIV genome
[Reaction:R-HSA-167484] Fall Back to Closed Pre-initiation Complex
[Pathway:R-HSA-167160] RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
[Reaction:R-HSA-167153] SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
[Reaction:R-HSA-167133] Activation of GT
[Reaction:R-HSA-167128] RNA Polymerase II CTD (phosphorylated) binds to CE
[Reaction:R-HSA-167098] Phosphorylation (Ser5) of RNA pol II CTD
[Reaction:R-HSA-167111] Extrusion of 5'-end of 30 nt long HIV-1 transcript through the pore in Pol II complex
[Complex:R-HSA-167102] HIV-1 transcription complex containing extruded transcript to +30 [nucleoplasm]
[Complex:R-HSA-167127] HIV-1 transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm]
[Complex:R-HSA-167107] RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm]
[Complex:R-HSA-167139] CE:Pol II CTD:Spt5 complex [nucleoplasm]
[Complex:R-HSA-167123] RNA Pol II with phosphorylated CTD: CE complex with activated GT [nucleoplasm]
[Pathway:R-HSA-167243] Tat-mediated HIV elongation arrest and recovery
[Reaction:R-HSA-167459] Abortive termination of HIV-1 elongation after arrest (Tat-containing elongation complex)
[Complex:R-HSA-167460] HIV-1 Tat-containing aborted elongation complex after arrest [nucleoplasm]
[Pathway:R-HSA-167290] Pausing and recovery of HIV elongation
[Reaction:R-HSA-167292] Resumption of elongation of HIV-1 transcript after recovery from pausing
[Reaction:R-HSA-167282] 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing
[Complex:R-HSA-167283] HIV-1 paused processive elongation complex [nucleoplasm]
[Pathway:R-HSA-167162] RNA Polymerase II HIV Promoter Escape
[Pathway:R-HSA-167161] HIV Transcription Initiation
[Reaction:R-HSA-167477] Abortive HIV-1 initiation after formation of the first phosphodiester bond
[Reaction:R-HSA-167468] Abortive HIV-1 Initiation After Second Transition
[Complex:R-HSA-167471] HIV-1 transcription complex containing 4-9 nucleotide long transcript [nucleoplasm]
[Reaction:R-HSA-167115] Addition of nucleotides between position +11 and +30 on HIV-1 transcript
[Reaction:R-HSA-167117] Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition
[Complex:R-HSA-167120] HIV-1 transcription complex containing transcript to +30 [nucleoplasm]
[Complex:R-HSA-167132] HIV-1 transcription complex containing 11 nucleotide long transcript [nucleoplasm]
[Reaction:R-HSA-167136] Addition of nucleotides 5 through 9 on the growing HIV-1 transcript
[Complex:R-HSA-167100] HIV-1 transcription complex containing 9 nucleotide long transcript [nucleoplasm]
[Reaction:R-HSA-167474] Abortive HIV-1 Initiation Before Second Transition
[BlackBoxEvent:R-HSA-167113] Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition
[Complex:R-HSA-167124] HIV-1 transcription complex containing 4 nucleotide long transcript [nucleoplasm]
[Complex:R-HSA-167472] HIV-1 Promoter Escape Complex [nucleoplasm]
[BlackBoxEvent:R-HSA-9613490] Unwinding of DNA for the nascent HIV-1 transcript: Second Transition
[BlackBoxEvent:R-HSA-167121] Addition of the third nucleotide on the nascent HIV-1 transcript
[BlackBoxEvent:R-HSA-9613498] Unwinding of DNA for the nascent HIV-1 transcript
[Reaction:R-HSA-167134] Newly formed phosphodiester bond stabilized and PPi released
[Reaction:R-HSA-167130] Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP
[Reaction:R-HSA-167118] NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex
[Reaction:R-HSA-167097] HIV Promoter Opening: First Transition
[Complex:R-HSA-167125] HIV-1 closed pre-initiation complex [nucleoplasm]
[Complex:R-HSA-167093] HIV-1 promoter:TFIID:TFIIA:TFIIB:Pol II:TFIIF complex* [nucleoplasm]
[Complex:R-HSA-167104] HIV-1 promoter:TFIID:TFIIA:TFIIB complex [nucleoplasm]
[Complex:R-HSA-167094] HIV-1 promoter:TFIID complex [nucleoplasm]
[Complex:R-HSA-175486] Integrated provirus [nucleoplasm]
[Complex:R-HSA-167137] HIV-1 open pre-initiation complex [nucleoplasm]
[Complex:R-HSA-167129] HIV-1 initiation complex [nucleoplasm]
[Complex:R-HSA-167106] HIV-1 initiation complex with phosphodiester-PPi intermediate [nucleoplasm]
[Complex:R-HSA-167101] HIV-1 transcription complex [nucleoplasm]
[Complex:R-HSA-167119] HIV-1 transcription complex containing 3 nucleotide long transcript [nucleoplasm]
[Pathway:R-HSA-167287] HIV elongation arrest and recovery
[Reaction:R-HSA-167481] Abortive termination of HIV-1 elongation after arrest
[Complex:R-HSA-167482] HIV-1 aborted elongation complex after arrest [nucleoplasm]
[Reaction:R-HSA-167288] TFIIS-mediated recovery of HIV-1 elongation from arrest
[Reaction:R-HSA-167284] 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest
[Complex:R-HSA-167286] HIV-1 arrested processive elongation complex [nucleoplasm]
[Complex:R-HSA-167081] HIV-1 processive elongation complex [nucleoplasm]
[Pathway:R-HSA-167238] Pausing and recovery of Tat-mediated HIV elongation
[Pathway:R-HSA-167169] HIV Transcription Elongation
[Pathway:R-HSA-167246] Tat-mediated elongation of the HIV-1 transcript
[Reaction:R-HSA-167197] Separation of elongating HIV-1 transcript from template
[Complex:R-HSA-167199] P-TEFb(Cyclin T1:Cdk9)-containing elongation complex with separated and uncleaved transcript [nucleoplasm]
[Reaction:R-HSA-167192] Pol II elongation complex moves on the HIV-1 template as transcript elongates
[Reaction:R-HSA-167148] TFIIS-mediated recovery of elongation from arrest
[Reaction:R-HSA-167090] 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest
[Complex:R-HSA-167091] HIV-1 Tat-containing arrested processive elongation complex [nucleoplasm]
[Reaction:R-HSA-167150] Resumption of elongation of HIV-1 transcript after recovery from pausing
[Reaction:R-HSA-167076] 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing
[Reaction:R-HSA-167181] Addition of nucleotides leads to HIV-1 transcript elongation
[Complex:R-HSA-167071] HIV-1 Tat-containing paused processive elongation complex [nucleoplasm]
[Complex:R-HSA-167193] Tat-containing elongation complex prior to separation [nucleoplasm]
[Complex:R-HSA-167184] HIV-1 Tat-containing processive elongation complex [nucleoplasm]
[Reaction:R-HSA-167196] Recruitment of elongation factors to form HIV-1 elongation complex
[Complex:R-HSA-167185] HIV-1 elongation complex containing Tat [nucleoplasm]
[Reaction:R-HSA-167191] Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex
[Reaction:R-HSA-170704] Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex
[Complex:R-HSA-170710] Tat-containing early elongation complex with hyperphosphorylated Pol II CTD ( phospho-NELF phospho DSIF) [nucleoplasm]
[Reaction:R-HSA-170706] Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex
[Complex:R-HSA-170707] Tat-containing early elongation complex with hyperphosphorylated Pol II CTD and phospho-NELF [nucleoplasm]
[Complex:R-HSA-167182] Tat-containing early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm]
[Pathway:R-HSA-167242] Abortive elongation of HIV-1 transcript in the absence of Tat
[Reaction:R-HSA-167147] Separation of abortive HIV-1 transcript from template
[Reaction:R-HSA-167087] Limited elongation of the HIV-1 transcript
[Complex:R-HSA-170736] Early elongation complex with separated aborted transcript [nucleoplasm]
[Complex:R-HSA-170726] DSIF:NELF:early elongation complex after limited nucleotide addition [nucleoplasm]
[Pathway:R-HSA-167158] Formation of the HIV-1 Early Elongation Complex
[Reaction:R-HSA-167478] Abortive termination of HIV-1 early transcription elongation by DSIF:NELF
[Complex:R-HSA-167467] Aborted HIV-1 early elongation complex [nucleoplasm]
[Pathway:R-HSA-167152] Formation of HIV elongation complex in the absence of HIV Tat
[Reaction:R-HSA-167077] Recruitment of elongation factors to form HIV-1 elongation complex
[Reaction:R-HSA-167084] Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
[Reaction:R-HSA-167085] Formation of DSIF:NELF:HIV-1 early elongation complex
[Reaction:R-HSA-167083] DSIF complex binds to RNA Pol II (hypophosphorylated)
[Reaction:R-HSA-167072] Hypophosphorylation of RNA Pol II CTD by FCP1P protein
[Reaction:R-HSA-167089] Recognition and binding of the HIV-1 mRNA cap by the cap-binding complex
[Complex:R-HSA-167080] HIV-1 capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm]
[Complex:R-HSA-167088] HIV-1 Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm]
[Complex:R-HSA-167078] DSIF:NELF:early elongation complex [nucleoplasm]
[Complex:R-HSA-167070] RNA Pol II (hypophosphorylated) complex bound to DSIF protein [nucleoplasm]
[Complex:R-HSA-167086] RNA Pol II (hypophosphorylated):capped pre-mRNA complex [nucleoplasm]
[Complex:R-HSA-167082] HIV-1 elongation complex [nucleoplasm]
[Complex:R-HSA-167075] HIV-1 early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm]
[Reaction:R-HSA-165055] Hydrolysis of Ran:GTP to Ran:GDP
[Reaction:R-HSA-180885] Rev multimer-bound HIV mRNA associates with Crm1
[Pathway:R-HSA-180746] Nuclear import of Rev protein
[Reaction:R-HSA-180728] Association of Ran-GTP with importin-beta
[Reaction:R-HSA-180736] Disassembly of the Rev-importin beta-B23:Ran-GTP complex
[Reaction:R-HSA-180732] Translocation of Rev:importin-beta:B23 to the nucleus
[Reaction:R-HSA-180710] Rev:importin beta:B23 recruited to the nuclear pore
[Reaction:R-HSA-180725] Rev associates with B23
[Reaction:R-HSA-180709] Association of multimerized Rev with beta-importin
[Reaction:R-HSA-165028] Release of the HIV mRNA and Crm1 from Rev in the cytoplasm
[Reaction:R-HSA-180739] Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex
[Reaction:R-HSA-165047] Translocation of nuclear RNA transport complex to cytoplasm
[Reaction:R-HSA-165043] Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC
[Reaction:R-HSA-165034] Rev multimer-bound HIV mRNA:CRM1 complex associates with Ran:GTP
[Reaction:R-HSA-165033] Multimerization of Rev
[Reaction:R-HSA-165027] Rev molecules assemble onto the RRE RNA sequence through their ARM sequence
[Complex:R-HSA-165531] Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP:NPC [nuclear envelope]
[Complex:R-HSA-165537] Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [nucleoplasm]
[Complex:R-HSA-180873] Rev multimer-bound HIV-1 mRNA:CRM1 complex [nucleoplasm]
[Complex:R-HSA-180718] RanBP1:Ran-GTP:CRM1:Rev-bound mRNA complex [cytosol]
[Complex:R-HSA-165552] Rev multimer-bound HIV-1 mRNA:Crm1:Ran:GTP [cytosol]
[Complex:R-HSA-180720] nucleoporin-associated Rev:Importin-beta:B23 complex [nuclear envelope]
[Complex:R-HSA-180724] Rev:Importin-beta:NPM1 [cytosol]
[Complex:R-HSA-180707] Importin beta-1:Rev multimer complex [cytosol]
[Complex:R-HSA-180712] Rev:importin-beta:B23:Ran-GTP complex [nucleoplasm]
[Complex:R-HSA-180711] Rev:Importin-beta:B23 [nucleoplasm]
[Complex:R-HSA-180713] Importin beta-1:Rev multimer complex [nucleoplasm]
[Pathway:R-HSA-180534] Vpu mediated degradation of CD4
[BlackBoxEvent:R-HSA-180573] Degradation of ubiquitinated CD4
[Complex:R-HSA-180567] Vpu:beta-TrCP1:Skp1 complex [endoplasmic reticulum membrane]
[Reaction:R-HSA-180597] Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex
[Complex:R-HSA-180530] multiubiquitinated CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane]
[Reaction:R-HSA-180599] The Vpu:CD4:beta-TrCP complex recruits SKP1
[Reaction:R-HSA-180591] Vpu:CD4 associates with beta-TrCP
[Reaction:R-HSA-180606] Association of Vpu with CD4
[Complex:R-HSA-180592] CD4:Vpu:beta-TrCP_1:Skp1 complex [endoplasmic reticulum membrane]
[Complex:R-HSA-180532] CD4:Vpu:beta-TrCP_1 [endoplasmic reticulum membrane]
[Complex:R-HSA-180601] CD4:Vpu complex [endoplasmic reticulum membrane]
[Pathway:R-HSA-180689] APOBEC3G mediated resistance to HIV-1 infection
[Reaction:R-HSA-180632] Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand
[Complex:R-HSA-180744] APOBEC3G:RTC with deaminated minus sssDNA:tRNA primer:RNA template [cytosol]
[Complex:R-HSA-180731] RTC with minus sssDNA containing deaminated C residues:tRNA primer:RNA template [cytosol]
[Complex:R-HSA-180727] minus sssDNA containing deaminated C residues:RNA template:tRNA primer [cytosol]
[Reaction:R-HSA-180634] Association of APOBEC3G with single-stranded region of forming HIV-1 minus strand
[Complex:R-HSA-180616] APOBEC3G:RTC with minus sssDNA:tRNA primer:RNA template [cytosol]
[Complex:R-HSA-173774] RTC with minus sssDNA:tRNA primer:RNA template [cytosol]
[Complex:R-HSA-173812] minus sssDNA:RNA template:tRNA primer [cytosol]
[Reaction:R-HSA-180630] Association of APOBEC3G with Gag
[Complex:R-HSA-180543] Vif:APOBEC3G complex [cytosol]
[Complex:R-HSA-180618] APOBEC3G:HIV-1PIC [cytosol]
[Pathway:R-HSA-176033] Interactions of Vpr with host cellular proteins
[Pathway:R-HSA-180910] Vpr-mediated nuclear import of PICs
[Reaction:R-HSA-180622] Vpr binds nucleoporins
[Complex:R-HSA-180610] PIC anchored to the NPC [nuclear envelope]
[Reaction:R-HSA-180627] Interaction of Vpr with importin alpha
[Complex:R-HSA-180623] Vpr:importin-alpha complex [cytosol]
[Complex:R-HSA-177526] IN bound to sticky 3' ends of viral DNA in PIC [cytosol]
[Pathway:R-HSA-180897] Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
[Pathway:R-HSA-176034] Interactions of Tat with host cellular proteins
[Reaction:R-HSA-167234] Association of Tat with P-TEFb(Cyclin T1:Cdk9)
[Reaction:R-HSA-167235] Formation of the P-TEFb(Cyclin T1:Cdk9) complex
[Complex:R-HSA-167237] Tat:P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm]
[Pathway:R-HSA-168181] Toll Like Receptor 7/8 (TLR7/8) Cascade
[Pathway:R-HSA-5621481] C-type lectin receptors (CLRs)
[Pathway:R-HSA-5621480] Dectin-2 family
[Reaction:R-HSA-5621371] CLEC4C binds HIV and HCV glycoproteins
[Complex:R-HSA-5621155] CLEC4C:FCER1G dimer:HIV gp120,HCV gp E2 [plasma membrane]
[Reaction:R-HSA-5621367] CLEC4A binds HIV and HCV glycoproteins
[Complex:R-HSA-5621150] CLEC4A:HIV gp120,HCV gpE2 [plasma membrane]
[BlackBoxEvent:R-HSA-1169307] Monoubiquitination of N-myristoyl GAG (P12493) protein
[Complex:R-HSA-184273] monoubiquitinated N-myristoyl GAG (P12493) protein [cytosol]
[Reaction:R-HSA-9835949] HIV Tat72 binds PKR
[Reaction:R-HSA-9836449] p-PKR dimer phosphorylates HIV tat
[Reaction:R-HSA-9839025] HIV TAR RNA binds PKR
[Complex:R-HSA-9835916] tat72:EIF2AK2 [cytosol]
[Complex:R-HSA-9839021] EIF2AK2:HIV TAR RNA [cytosol]
[Reaction:R-HSA-1471354] HNP1-3 bind gp120
[Complex:R-HSA-1471336] HNP1-3:gp120 [viral envelope]
[BlackBoxEvent:R-HSA-3245943] Viral DNA cleavage by TREX1
[Reaction:R-HSA-3244605] TREX1 binds retroviral-derived DNA
[Complex:R-HSA-3244619] TREX1:viral DNA [endoplasmic reticulum membrane]
[Reaction:R-HSA-1834939] STING recruits TBK1 and IRF3
[Reaction:R-HSA-1834951] IFI16 binds cytosolic dsDNA
[Reaction:R-HSA-3244614] cGAS produces cyclic GMP-AMP
[Reaction:R-HSA-3244647] cGAS binds cytosolic DNA
[Complex:R-HSA-3244625] cGAS:dsDNA [cytosol]
[Complex:R-HSA-1834947] dsDNA:IFI16 [cytosol]
[Pathway:R-HSA-9708296] tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis
[BlackBoxEvent:R-HSA-9708408] DICER1 cleaves tRNA Lys TTT 3 in tRNA:HIV RNA hybrid
[Complex:R-HSA-173798] HIV-1 RNA template:tRNA primer [cytosol]
[Complex:R-HSA-188132] C-ter TLR7 dimer:TLR7, TLR8 ligands [endosome membrane]
[DefinedSet:R-HSA-975158] Activated TLR7-9 homodimers [endosome membrane]
[Complex:R-HSA-975114] oligo-MyD88:activated TLR7-9 [endosome membrane]
[Complex:R-HSA-975159] p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane]
[Complex:R-HSA-975107] p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
[Complex:R-HSA-975148] TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
[Complex:R-HSA-975131] IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
[Complex:R-HSA-975178] hp-IRAK1 or p-IRAK2 bound to the pIRAK4:MyD88:activated TLR7/8 or 9 complex [endosome membrane]
[Complex:R-HSA-975182] TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
[Complex:R-HSA-975146] IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane]
[Complex:R-HSA-975133] p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR 7/8 or9 [endosome membrane]
[Complex:R-HSA-975113] IRAK1/or IRAK2 :p-S,2T-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
[Complex:R-HSA-975183] IRAK4:oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
[Complex:R-HSA-975124] MyD88 complexed with the activated TLR receptor [endosome membrane]
[Complex:R-HSA-9691207] TLR8 dimer:TLR7,TLR8 ligands [endosome membrane]
[Reaction:R-HSA-167983] C-ter TLR7 dimer binds TLR7, TLR8 ligands
[Reaction:R-HSA-975175] MyD88 interacts with the activated TLR receptor 7, 8 or 9
[Reaction:R-HSA-975098] MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88
[Reaction:R-HSA-975156] IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex
[Reaction:R-HSA-975170] IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9
[Reaction:R-HSA-975115] IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9
[Reaction:R-HSA-975160] Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9
[Complex:R-HSA-975161] pp-IRAK1:p-IRAK4:oligo-MyD88:activated TLR 7/8 or 9 complex [endosome membrane]
[Complex:R-HSA-975130] p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane]
[Complex:R-HSA-975132] IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
[Reaction:R-HSA-975180] First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
[Reaction:R-HSA-975134] Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9
[Reaction:R-HSA-975125] Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9
[Reaction:R-HSA-975111] TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9
[Reaction:R-HSA-975188] TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation
[Reaction:R-HSA-975106] Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation
[Reaction:R-HSA-975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
[Complex:R-HSA-180906] ANT1:Vpr complex [mitochondrial inner membrane]
[Reaction:R-HSA-180855] Translocation of Vpr to the mitochondria
[Reaction:R-HSA-180905] Association of Vpr with ANT1
[Pathway:R-HSA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
[Complex:R-HSA-975174] K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane]
[BlackBoxEvent:R-HSA-975118] TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex
[Pathway:R-HSA-975110] TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome
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