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Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 Show undefined attributes

authored

[InstanceEdit:937084] Shamovsky, V, 2010年08月25日

catalystActivity

[CatalystActivity:1014248] protein serine/threonine kinase activity of p-IRAK1:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 complex [endosome membrane]

category transition

compartment

created [InstanceEdit:975168] Shamovsky, V, 2010年09月22日

dbId 975134

displayName Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9

edited

[InstanceEdit:1014278] Shamovsky, V, 2010年11月15日

eventOf

[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome - Homo sapiens

followingEvent

[Reaction:R-HSA-975125] Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 - Homo sapiens

input

isInDisease false

isInferred false

literatureReference

[LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9

output

precedingEvent

[Reaction:R-HSA-975180] First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 - Homo sapiens

relatedSpecies

releaseDate 2010年12月14日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:983288] Gillespie, ME, 2010年10月29日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-975134

summation

[Summation:169777] Second, Thr387 in the activation loop is phosphorylated, lea...

Referrals

(hasEvent)

[Pathway:R-HSA-975155] MyD88 dependent cascade initiated on endosome

(precedingEvent)

[Reaction:R-HSA-975125] Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9

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