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Entries
Rev-mediated nuclear export of HIV RNA
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authored
[InstanceEdit:165064] Matthews, L, Rice, AP, 2005年07月27日 00:00:00
created
[InstanceEdit:165042] Matthews, L, 2005年07月26日 23:04:06
crossReference
[DatabaseIdentifier:12758000] BioModels Database:BIOMD0000000192
[DatabaseIdentifier:11944912] Mondo:0005109
dbId
165054
disease
[Disease:1660559] Human immunodeficiency virus infectious disease
displayName
Rev-mediated nuclear export of HIV RNA
edited
[InstanceEdit:180928] Matthews, L, 2006年06月07日 20:09:58
eventOf
[Pathway:R-HSA-162599] Late Phase of HIV Life Cycle - Homo sapiens
figure
[Figure:167731] /figures/RNA_transport.jpg
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-165027] Rev molecules assemble onto the RRE RNA sequence through their ARM sequence - Homo sapiens
[Reaction:R-HSA-165033] Multimerization of Rev - Homo sapiens
[Reaction:R-HSA-180885] Rev multimer-bound HIV mRNA associates with Crm1 - Homo sapiens
[Reaction:R-HSA-180687] Conversion of Ran-GDP to Ran-GTP - Homo sapiens
[Reaction:R-HSA-165034] Rev multimer-bound HIV mRNA:CRM1 complex associates with Ran:GTP - Homo sapiens
[Reaction:R-HSA-165043] Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC - Homo sapiens
[Reaction:R-HSA-165047] Translocation of nuclear RNA transport complex to cytoplasm - Homo sapiens
[Reaction:R-HSA-180739] Association of RanBP1 with Ran-GTP:CRM1:Rev:mRNA complex - Homo sapiens
[Reaction:R-HSA-165028] Release of the HIV mRNA and Crm1 from Rev in the cytoplasm - Homo sapiens
[Reaction:R-HSA-165055] Hydrolysis of Ran:GTP to Ran:GDP - Homo sapiens
isInDisease
true
isInferred
false
lastUpdatedDate
2015年09月30日
literatureReference
[LiteratureReference:165039] HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs
[LiteratureReference:165620] Retroviruses as model systems for the study of nuclear RNA export
[LiteratureReference:165623] Nuclear mRNA export: insights from virology
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
Rev-mediated nuclear export of HIV RNA
precedingEvent
[Pathway:R-HSA-167172] Transcription of the HIV genome - Homo sapiens
relatedSpecies
[Species:164493] Human immunodeficiency virus 1
releaseDate
2005年04月11日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:192365] Kumar, A, 2007年01月31日 22:47:49
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-165054
summation
[Summation:165618] The HIV-1 genome contains 9 genes encoded by a single trans...
updateTrackers
[UpdateTracker:9788077] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v44:[updateContainedRLE]
[UpdateTracker:9790557] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v33:[addHasEvent, updateContainedRLE]
[UpdateTracker:9792487] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v20:[addHasEvent]
[UpdateTracker:9784455] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v54:[updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9788077] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v44:[updateContainedRLE]
[UpdateTracker:9790557] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v33:[addHasEvent, updateContainedRLE]
[UpdateTracker:9792487] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v20:[addHasEvent]
[UpdateTracker:9784455] Update Tracker - [Pathway:165054] Rev-mediated nuclear export of HIV RNA - v54:[updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-162599] Late Phase of HIV Life Cycle
[Pathway:R-HSA-177243] Interactions of Rev with host cellular proteins
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