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Schema
>
Reaction
>
Entries
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
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authored
[InstanceEdit:166017] de Bono, B, 2005年08月16日 10:54:15
category
dissociation
compartment
[Compartment:74700] endosome membrane
created
[InstanceEdit:975168] Shamovsky, V, 2010年09月22日
dbId
975100
displayName
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
edited
[InstanceEdit:1014262] Shamovsky, V, 2010年11月15日
eventOf
[Pathway:R-HSA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Homo sapiens
followingEvent
[Reaction:R-HSA-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments - Homo sapiens
input
[Complex:R-HSA-975182] TRAF6:hp-IRAK1/or p-IRAK2:p-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:165896] Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling
[LiteratureReference:450126] IRAK1: a critical signaling mediator of innate immunity
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex
orthologousEvent
[Reaction:R-GGA-532630] p-IRAK2- TRAF6 dissociates from the activated TRL7 or 21 - Gallus gallus
output
4 ×
[Complex:R-HSA-975126] hp-IRAK1/or p-IRAK2 :TRAF6 [endosome membrane]
[Complex:R-HSA-975159] p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 receptor [endosome membrane]
precedingEvent
[Reaction:R-HSA-975111] TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 - Homo sapiens
relatedSpecies
[Species:9678119] Human SARS coronavirus
[Species:164493] Human immunodeficiency virus 1
[Species:9031716] Influenza A virus
[Species:9681683] Severe acute respiratory syndrome coronavirus 2
releaseDate
2010年12月14日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:983288] Gillespie, ME, 2010年10月29日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-975100
summation
[Summation:940394] Hyperphosphorylated IRAK1 and TRAF6 are thought to dissociat...
updateTrackers
[UpdateTracker:9788511] Update Tracker - [Reaction:975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex - v41:[modifyText]
[UpdateTracker:9788152] Update Tracker - [Reaction:975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex - v43:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9788511] Update Tracker - [Reaction:975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex - v41:[modifyText]
[UpdateTracker:9788152] Update Tracker - [Reaction:975100] Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex - v43:[modifyText]
(hasEvent)
[Pathway:R-HSA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
(precedingEvent)
[Reaction:R-HSA-975185] IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments
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