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Schema
>
Reaction
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Entries
TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis
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authored
[InstanceEdit:9686671] Gillespie, Marc E, 2020年05月05日
catalystActivity
[CatalystActivity:9686728] serine-type endopeptidase activity of TMPRSS2 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:9686727] Gillespie, Marc E, 2020年05月05日
crossReference
[DatabaseIdentifier:11944911] Mondo:0005091
dbId
9686731
disease
[Disease:9678120] severe acute respiratory syndrome
displayName
TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis
edited
[InstanceEdit:9690126] Gillespie, Marc E, 2020年05月26日
eventOf
[Pathway:R-HSA-9678110] Attachment and Entry - Homo sapiens
followingEvent
[Reaction:R-HSA-9686699] Fusion and Release of SARS-CoV-1 Nucleocapsid - Homo sapiens
input
[Complex:R-HSA-9686311] S3:M:E:encapsidated SARS coronavirus genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2 [extracellular region]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9681513] A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry
[LiteratureReference:9687564] Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2
[LiteratureReference:9687530] Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis
output
[EntityWithAccessionedSequence:R-HSA-9698958] ACE2 [endocytic vesicle membrane]
[Complex:R-COV-9686703] S1:S2:M:E:encapsidated SARS coronavirus genomic RNA: 7a:O-glycosyl 3a tetramer [endocytic vesicle lumen]
precedingEvent
[Reaction:R-HSA-9678128] Spike glycoprotein of SARS coronavirus binds ACE2 on host cell - Homo sapiens
regulatedBy
[NegativeRegulation:9686783] Negative regulation by 'TMPRSS2:TMPRSS2 inhibitors [plasma membrane]'
relatedSpecies
[Species:9678119] Human SARS coronavirus
releaseDate
2020年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020年05月27日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9686731
summation
[Summation:9687545] Transmembrane protease serine 2 (TMPRSS2), associated with t...
updateTrackers
[UpdateTracker:9776814] Update Tracker - [Reaction:9686731] TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis - v74:[addOutput]
Referrals
(updatedInstance)
[UpdateTracker:9776814] Update Tracker - [Reaction:9686731] TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis - v74:[addOutput]
(hasEvent)
[Pathway:R-HSA-9678110] Attachment and Entry
(precedingEvent)
[Reaction:R-HSA-9686699] Fusion and Release of SARS-CoV-1 Nucleocapsid
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