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Schema > BlackBoxEvent > Entries

N-glycan trimming of Spike Show undefined attributes

authored

[InstanceEdit:9683645] Stephan, Ralf, 2020年04月08日

catalystActivity

[CatalystActivity:9683658] glucan 1,3-alpha-glucosidase activity of ER alpha-glucosidases [endoplasmic reticulum lumen]

category uncertain

compartment

[Compartment:17957] endoplasmic reticulum lumen

created [InstanceEdit:9683729] Stephan, Ralf, 2020年04月17日

crossReference

[DatabaseIdentifier:11944911] Mondo:0005091

dbId 9683663

disease

[Disease:9678120] severe acute respiratory syndrome

displayName N-glycan trimming of Spike

edited

[InstanceEdit:9689806] D'Eustachio, Peter, 2020年05月21日

eventOf

[Pathway:R-HSA-9683686] Maturation of spike protein - Homo sapiens

followingEvent

[Reaction:R-HSA-9683772] Trimmed spike protein binds to calnexin - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

[LiteratureReference:9682986] Inhibition of endoplasmic reticulum-resident glucosidases impairs severe acute respiratory syndrome coronavirus and human coronavirus NL63 spike protein-mediated entry by altering the glycan processing of angiotensin I-converting enzyme 2

maxDepth 1

modified [InstanceEdit:9937650] Stephan, Ralf, 2025年02月05日

name

N-glycan trimming of Spike

output

precedingEvent

[BlackBoxEvent:R-HSA-9683755] Spike protein gets N-glycosylated - Homo sapiens

regulatedBy

[NegativeRegulation:9686823] Negative regulation by 'ER-alpha glucosidases:ER-alpha glucosidase inhibitors [endoplasmic reticulum lumen]'

relatedSpecies

[Species:9678119] Human SARS coronavirus

releaseDate 2020年06月10日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020年05月27日

schemaClass BlackBoxEvent

species

[Species:48887] Homo sapiens

stId R-HSA-9683663

summation

[Summation:9682937] N-glycan side chains on the nascent SARS-CoV-1 spike protein...

Referrals

(hasEvent)

[Pathway:R-HSA-9683686] Maturation of spike protein

(precedingEvent)

[Reaction:R-HSA-9683772] Trimmed spike protein binds to calnexin

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