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Reaction
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Entries
SUMO-p-N protein dimer binds genomic RNA
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authored
[InstanceEdit:9685154] Rothfels, Karen, 2020年04月22日
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created
[InstanceEdit:9684231] Rothfels, Karen, 2020年04月21日
crossReference
[DatabaseIdentifier:11944911] Mondo:0005091
dbId
9684229
disease
[Disease:9678120] severe acute respiratory syndrome
displayName
SUMO-p-N protein dimer binds genomic RNA
edited
[InstanceEdit:9685483] Rothfels, Karen, 2020年04月23日
eventOf
[Pathway:R-HSA-9679509] Virion Assembly and Release - Homo sapiens
followingEvent
[Reaction:R-HSA-9684234] Encapsidation of SARS coronavirus genomic RNA - Homo sapiens
input
[EntityWithAccessionedSequence:R-COV-9685518] m7G(5')pppAm-capped, polyadenylated SARS-CoV-1 genomic RNA (plus strand) [cytosol]
[Complex:R-COV-9684203] SUMO1-K62-p-S177-N dimer [endoplasmic reticulum-Golgi intermediate compartment membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9683990] The SARS coronavirus nucleocapsid protein--forms and functions
[LiteratureReference:9683948] Modular organization of SARS coronavirus nucleocapsid protein
[LiteratureReference:9683953] Multiple nucleic acid binding sites and intrinsic disorder of severe acute respiratory syndrome coronavirus nucleocapsid protein: implications for ribonucleocapsid protein packaging
[LiteratureReference:9683934] Analysis of multimerization of the SARS coronavirus nucleocapsid protein
[LiteratureReference:9683940] Carboxyl terminus of severe acute respiratory syndrome coronavirus nucleocapsid protein: self-association analysis and nucleic acid binding characterization
[LiteratureReference:9683993] The dimer interface of the SARS coronavirus nucleocapsid protein adapts a porcine respiratory and reproductive syndrome virus-like structure
[LiteratureReference:9682783] The nucleocapsid protein of the SARS coronavirus is capable of self-association through a C-terminal 209 amino acid interaction domain
[LiteratureReference:9683966] Recombinant severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein forms a dimer through its C-terminal domain
[LiteratureReference:9683069] Transient oligomerization of the SARS-CoV N protein--implication for virus ribonucleoprotein packaging
[LiteratureReference:9683992] The SARS-CoV nucleocapsid protein: a protein with multifarious activities
[LiteratureReference:9682961] The severe acute respiratory syndrome coronavirus nucleocapsid protein is phosphorylated and localizes in the cytoplasm by 14-3-3-mediated translocation
[LiteratureReference:5665592] The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer
[LiteratureReference:9683962] Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization
[LiteratureReference:9683975] Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein
[LiteratureReference:9683984] Structure of the SARS coronavirus nucleocapsid protein RNA-binding dimerization domain suggests a mechanism for helical packaging of viral RNA
[LiteratureReference:9683969] Solution structure of the c-terminal dimerization domain of SARS coronavirus nucleocapsid protein solved by the SAIL-NMR method
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
SUMO-p-N protein dimer binds genomic RNA
output
[Complex:R-COV-9684230] SUMO-p-N dimer:SARS coronavirus genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane]
precedingEvent
[BlackBoxEvent:R-HSA-9683765] Nucleoprotein translocates to the ERGIC outer membrane - Homo sapiens
[BlackBoxEvent:R-HSA-9685519] Polyadenylation of SARS-CoV-1 genomic RNA (plus strand) - Homo sapiens
[BlackBoxEvent:R-HSA-9682465] RTC completes synthesis of the minus strand genomic RNA complement - Homo sapiens
relatedSpecies
[Species:9678119] Human SARS coronavirus
releaseDate
2020年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020年05月27日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9684229
summation
[Summation:9684222] N protein is synthesized in the cytosol of the host cell and...
updateTrackers
[UpdateTracker:9776659] Update Tracker - [Reaction:9684229] SUMO-p-N protein dimer binds genomic RNA - v74:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9776659] Update Tracker - [Reaction:9684229] SUMO-p-N protein dimer binds genomic RNA - v74:[modifyText]
(hasEvent)
[Pathway:R-HSA-9679509] Virion Assembly and Release
(precedingEvent)
[Reaction:R-HSA-9684234] Encapsidation of SARS coronavirus genomic RNA
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