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Schema
>
Reaction
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Entries
SARS-CoV-1 gRNA complement (minus strand):RTC binds RTC inhibitors
Show undefined attributes
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authored
[InstanceEdit:9687387] Jassal, Bijay, 2020年05月07日
category
binding
compartment
[Compartment:9684675] double membrane vesicle viral factory outer membrane
created
[InstanceEdit:9687387] Jassal, Bijay, 2020年05月07日
crossReference
[DatabaseIdentifier:11944911] Mondo:0005091
dbId
9687384
definition
Inhibition
disease
[Disease:9678120] severe acute respiratory syndrome
displayName
SARS-CoV-1 gRNA complement (minus strand):RTC binds RTC inhibitors
edited
[InstanceEdit:9687387] Jassal, Bijay, 2020年05月07日
eventOf
[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome - Homo sapiens
input
[DefinedSet:R-ALL-9687408] RTC inhibitors [double membrane vesicle viral factory outer membrane]
[Complex:R-COV-9682253] SARS-CoV-1 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9680274] Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase
[LiteratureReference:9680275] Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
[LiteratureReference:9680461] The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus
[LiteratureReference:9684014] Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses
[LiteratureReference:9682443] An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
[LiteratureReference:9682430] Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia
[LiteratureReference:9689384] Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
SARS-CoV-1 gRNA complement (minus strand):RTC binds RTC inhibitors
output
[Complex:R-COV-9687382] SARS-CoV-1 gRNA complement (minus strand):RTC:RTC inhibitors [double membrane vesicle viral factory outer membrane]
relatedSpecies
[Species:9678119] Human SARS coronavirus
releaseDate
2020年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9688552] Shoichet, Brian, 2020年05月14日
[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020年05月27日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9687384
summation
[Summation:9687383] Remdesivir (GS-5734) is an investigational nucleotide analog...
Referrals
(hasEvent)
[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome
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