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Schema
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Entries
Replication of the SARS-CoV-1 genome
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authored
[InstanceEdit:9686443] Orlic-Milacic, Marija, 2020年04月30日
created
[InstanceEdit:9682707] Orlic-Milacic, Marija, 2020年04月13日
crossReference
[DatabaseIdentifier:11944911] Mondo:0005091
dbId
9682706
disease
[Disease:9678120] severe acute respiratory syndrome
displayName
Replication of the SARS-CoV-1 genome
edited
[InstanceEdit:9687600] Orlic-Milacic, Marija, 2020年05月11日
eventOf
[Pathway:R-HSA-9679514] SARS-CoV-1 Genome Replication and Transcription - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-9681314] Replication transcription complex binds SARS-CoV-1 genomic RNA - Homo sapiens
[BlackBoxEvent:R-HSA-9682695] nsp13 helicase melts secondary structures in SARS-CoV-1 genomic RNA template - Homo sapiens
[BlackBoxEvent:R-HSA-9681651] nsp8 generates RNA primers - Homo sapiens
[BlackBoxEvent:R-HSA-9681674] nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement - Homo sapiens
[BlackBoxEvent:R-HSA-9682563] nsp12 misincorporates a nucleotide in nascent RNA minus strand - Homo sapiens
[Reaction:R-HSA-9680262] SARS coronavirus gRNA:RTC:RNA primer binds RTC inhibitors - Homo sapiens
[Reaction:R-HSA-9682603] nsp14 acts as a 3'-to-5' exonuclease to remove misincorporated nucleotides from nascent RNA - Homo sapiens
[BlackBoxEvent:R-HSA-9682465] RTC completes synthesis of the minus strand genomic RNA complement - Homo sapiens
[Reaction:R-HSA-9687388] SARS-CoV-1 gRNA:RTC:nascent RNA minus strand binds RTC inhibitors - Homo sapiens
[BlackBoxEvent:R-HSA-9684018] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) - Homo sapiens
[Reaction:R-HSA-9684030] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA complement (minus strand) - Homo sapiens
[Reaction:R-HSA-9685597] RTC binds SARS-CoV-1 genomic RNA complement (minus strand) - Homo sapiens
[BlackBoxEvent:R-HSA-9681840] RTC synthesizes SARS-CoV-1 plus strand genomic RNA - Homo sapiens
[Reaction:R-HSA-9687384] SARS-CoV-1 gRNA complement (minus strand):RTC binds RTC inhibitors - Homo sapiens
[BlackBoxEvent:R-HSA-9684017] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) - Homo sapiens
[Reaction:R-HSA-9684032] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand) - Homo sapiens
[BlackBoxEvent:R-HSA-9685519] Polyadenylation of SARS-CoV-1 genomic RNA (plus strand) - Homo sapiens
[Reaction:R-HSA-9682009] ZCRB1 binds 5'UTR of SARS-CoV-1 genomic RNA - Homo sapiens
[Reaction:R-HSA-9682631] nsp13 binds DDX5 - Homo sapiens
[Reaction:R-HSA-9682712] nsp15 binds RB1 - Homo sapiens
[Reaction:R-HSA-9683455] nsp16 binds VHL - Homo sapiens
isInDisease
true
isInferred
false
lastUpdatedDate
2021年12月08日
literatureReference
[LiteratureReference:9685640] The Nonstructural Proteins Directing Coronavirus RNA Synthesis and Processing
[LiteratureReference:9679510] Human Coronavirus: Host-Pathogen Interaction
[LiteratureReference:9685858] The structure and functions of coronavirus genomic 3' and 5' ends
maxDepth
2
modified
[InstanceEdit:9847082] Weiser, Joel, 2023年10月12日
name
Replication of the SARS-CoV-1 genome
relatedSpecies
[Species:9678119] Human SARS coronavirus
releaseDate
2020年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020年05月27日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9682706
summation
[Summation:9686438] The plus strand RNA genome of the human SARS coronavirus 1 (...
updateTrackers
[UpdateTracker:9776250] Update Tracker - [Pathway:9682706] Replication of the SARS-CoV-1 genome - v77:[removeHasEvent]
[UpdateTracker:9775330] Update Tracker - [Pathway:9682706] Replication of the SARS-CoV-1 genome - v79:[updateContainedRLE]
[UpdateTracker:9776423] Update Tracker - [Pathway:9682706] Replication of the SARS-CoV-1 genome - v76:[updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9776250] Update Tracker - [Pathway:9682706] Replication of the SARS-CoV-1 genome - v77:[removeHasEvent]
[UpdateTracker:9775330] Update Tracker - [Pathway:9682706] Replication of the SARS-CoV-1 genome - v79:[updateContainedRLE]
[UpdateTracker:9776423] Update Tracker - [Pathway:9682706] Replication of the SARS-CoV-1 genome - v76:[updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-9679514] SARS-CoV-1 Genome Replication and Transcription
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