Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
BlackBoxEvent
>
Entries
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)
Show undefined attributes
Go to Details
authored
[InstanceEdit:9686443] Orlic-Milacic, Marija, 2020年04月30日
catalystActivity
[CatalystActivity:9713310] mRNA 5'-cap (guanine-N7-)-methyltransferase activity of SARS-CoV-1 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane]
category
uncertain
compartment
[Compartment:70101] cytosol
[Compartment:9684675] double membrane vesicle viral factory outer membrane
created
[InstanceEdit:9684019] Orlic-Milacic, Marija, 2020年04月20日
crossReference
[DatabaseIdentifier:11944911] Mondo:0005091
dbId
9684017
disease
[Disease:9678120] severe acute respiratory syndrome
displayName
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)
edited
[InstanceEdit:9687600] Orlic-Milacic, Marija, 2020年05月11日
eventOf
[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome - Homo sapiens
followingEvent
[Reaction:R-HSA-9684032] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand) - Homo sapiens
input
[SimpleEntity:R-ALL-29438] GTP [cytosol]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
[SimpleEntity:R-ALL-9639461] S-adenosyl-L-methionine [cytosol]
[Complex:R-COV-9713311] SARS-CoV-1 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9684025] Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)
output
[Complex:R-COV-9713313] m7GpppA-capped SARS-CoV-1 genomic RNA (plus strand):RTC [double membrane vesicle viral factory outer membrane]
[SimpleEntity:R-ALL-29372] Pi [cytosol]
[SimpleEntity:R-ALL-111294] PPi [cytosol]
[SimpleEntity:R-ALL-9639443] S-adenosyl-L-homocysteine [cytosol]
precedingEvent
[BlackBoxEvent:R-HSA-9681840] RTC synthesizes SARS-CoV-1 plus strand genomic RNA - Homo sapiens
relatedSpecies
[Species:9678119] Human SARS coronavirus
releaseDate
2020年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020年05月27日
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-9684017
summation
[Summation:9685170] The genomic and subgenomic mRNAs of SARS-CoV-1 coronavirus, ...
updateTrackers
[UpdateTracker:9776351] Update Tracker - [BlackBoxEvent:9684017] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) - v76:[add_removeCatalystActivity, add_removeInput, add_removeOutput]
Referrals
(updatedInstance)
[UpdateTracker:9776351] Update Tracker - [BlackBoxEvent:9684017] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) - v76:[add_removeCatalystActivity, add_removeInput, add_removeOutput]
(hasEvent)
[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome
(precedingEvent)
[Reaction:R-HSA-9684032] nsp16 acts as a cap 2'-O-methyltransferase to modify SARS-CoV-1 gRNA (plus strand)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル