Reactome | RTC synthesizes SARS-CoV-1 plus strand genomic RNA

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RTC synthesizes SARS-CoV-1 plus strand genomic RNA Show undefined attributes

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authored

[InstanceEdit:9686443] Orlic-Milacic, Marija, 2020年04月30日

catalystActivity

[CatalystActivity:9682251] RNA-directed RNA polymerase activity of SARS-CoV-1 gRNA complement (minus strand):RTC [double membrane vesicle viral factory outer membrane]

category uncertain

compartment

created [InstanceEdit:9681841] Orlic-Milacic, Marija, 2020年04月06日

crossReference

[DatabaseIdentifier:11944911] Mondo:0005091

dbId 9681840

disease

[Disease:9678120] severe acute respiratory syndrome

displayName RTC synthesizes SARS-CoV-1 plus strand genomic RNA

edited

[InstanceEdit:9687600] Orlic-Milacic, Marija, 2020年05月11日

eventOf

[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome - Homo sapiens

followingEvent

[BlackBoxEvent:R-HSA-9684017] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand) - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

RTC synthesizes SARS-CoV-1 plus strand genomic RNA

output

precedingEvent

[Reaction:R-HSA-9685597] RTC binds SARS-CoV-1 genomic RNA complement (minus strand) - Homo sapiens

regulatedBy

[NegativeGeneExpressionRegulation:9687389] Negative gene expression regulation by 'SARS-CoV-1 gRNA complement (minus strand):RTC:RTC inhibitors [double membrane vesicle viral factory outer membrane]'

relatedSpecies

[Species:9678119] Human SARS coronavirus

releaseDate 2020年06月10日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020年05月27日

schemaClass BlackBoxEvent

species

[Species:48887] Homo sapiens

stId R-HSA-9681840

summation

[Summation:9681844] After synthesizing the complementary minus RNA of the plus s...

updateTrackers

[UpdateTracker:9776360] Update Tracker - [BlackBoxEvent:9681840] RTC synthesizes SARS-CoV-1 plus strand genomic RNA - v76:[add_removeOutput]

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(updatedInstance)

[UpdateTracker:9776360] Update Tracker - [BlackBoxEvent:9681840] RTC synthesizes SARS-CoV-1 plus strand genomic RNA - v76:[add_removeOutput]

(hasEvent)

[Pathway:R-HSA-9682706] Replication of the SARS-CoV-1 genome

(precedingEvent)

[BlackBoxEvent:R-HSA-9684017] nsp14 acts as a cap N7 methyltransferase to modify SARS-CoV-1 gRNA (plus strand)

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Reactome Pathway Database

RTC synthesizes SARS-CoV-1 plus strand genomic RNA Show undefined attributes

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