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Schema
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Reaction
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Entries
E and N are recruited to the M lattice
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authored
[InstanceEdit:9685154] Rothfels, Karen, 2020年04月22日
category
binding
compartment
[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created
[InstanceEdit:9684237] Rothfels, Karen, 2020年04月21日
crossReference
[DatabaseIdentifier:11944911] Mondo:0005091
dbId
9684238
disease
[Disease:9678120] severe acute respiratory syndrome
displayName
E and N are recruited to the M lattice
edited
[InstanceEdit:9685483] Rothfels, Karen, 2020年04月23日
eventOf
[Pathway:R-HSA-9679509] Virion Assembly and Release - Homo sapiens
followingEvent
[Reaction:R-HSA-9684241] Recruitment of Spike trimer to assembling virion - Homo sapiens
input
[Complex:R-COV-9684199] encapsidated SARS coronavirus genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane]
[Complex:R-COV-9684216] M lattice [endoplasmic reticulum-Golgi intermediate compartment membrane]
3 ×
[Complex:R-COV-9683621] Ub-3xPalmC-E pentamer [Golgi membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9680341] The molecular biology of coronaviruses
[LiteratureReference:9679510] Human Coronavirus: Host-Pathogen Interaction
[LiteratureReference:9685450] Incorporation of spike and membrane glycoproteins into coronavirus virions
[LiteratureReference:9684168] Generation of synthetic severe acute respiratory syndrome coronavirus pseudoparticles: implications for assembly and vaccine production
[LiteratureReference:9684137] Assembly of human severe acute respiratory syndrome coronavirus-like particles
[LiteratureReference:9684142] Assembly of severe acute respiratory syndrome coronavirus RNA packaging signal into virus-like particles is nucleocapsid dependent
[LiteratureReference:9684163] Efficient assembly and release of SARS coronavirus-like particles by a heterologous expression system
[LiteratureReference:9684187] The M, E, and N structural proteins of the severe acute respiratory syndrome coronavirus are required for efficient assembly, trafficking, and release of virus-like particles
[LiteratureReference:9685370] The transmembrane oligomers of coronavirus protein E
[LiteratureReference:9682946] Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein
[LiteratureReference:9682982] Biochemical evidence for the presence of mixed membrane topologies of the severe acute respiratory syndrome coronavirus envelope protein expressed in mammalian cells
[LiteratureReference:9685364] Interactions between M protein and other structural proteins of severe, acute respiratory syndrome-associated coronavirus
[LiteratureReference:9685362] Expression and membrane integration of SARS-CoV E protein and its interaction with M protein
[LiteratureReference:9685354] Coronavirus envelope protein: current knowledge
[LiteratureReference:9685353] Coronavirus envelope protein: a small membrane protein with multiple functions
[LiteratureReference:9684155] Dissection and identification of regions required to form pseudoparticles by the interaction between the nucleocapsid (N) and membrane (M) proteins of SARS coronavirus
[LiteratureReference:9685350] Characterization of protein-protein interactions between the nucleocapsid protein and membrane protein of the SARS coronavirus
[LiteratureReference:9685368] Severe acute respiratory syndrome coronavirus membrane protein interacts with nucleocapsid protein mostly through their carboxyl termini by electrostatic attraction
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
E and N are recruited to the M lattice
orthologousEvent
[Reaction:R-HSA-9694444] E and N are recruited to the M lattice - Homo sapiens
output
[Complex:R-COV-9684226] M lattice:E protein:encapsidated SARS coronavirus genomic RNA [endoplasmic reticulum-Golgi intermediate compartment membrane]
precedingEvent
[Reaction:R-HSA-9684218] M protein oligomerization - Homo sapiens
[Reaction:R-HSA-9684234] Encapsidation of SARS coronavirus genomic RNA - Homo sapiens
relatedSpecies
[Species:9678119] Human SARS coronavirus
releaseDate
2020年06月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9690206] Acencio, Marcio Luis, Mazein, Alexander, 2020年05月27日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9684238
summation
[Summation:9685372] Formation of an M lattice nucleates recruitment of other str...
updateTrackers
[UpdateTracker:9776662] Update Tracker - [Reaction:9684238] E and N are recruited to the M lattice - v74:[add_removeInput]
Referrals
(updatedInstance)
[UpdateTracker:9776662] Update Tracker - [Reaction:9684238] E and N are recruited to the M lattice - v74:[add_removeInput]
(hasEvent)
[Pathway:R-HSA-9679509] Virion Assembly and Release
(precedingEvent)
[Reaction:R-HSA-9684241] Recruitment of Spike trimer to assembling virion
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