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Entries
RAF/MAP kinase cascade
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authored
[InstanceEdit:5674528] Rothfels, Karen, 2015年02月12日
created
[InstanceEdit:5673002] Rothfels, Karen, 2015年02月06日
crossReference
[DatabaseIdentifier:12757960] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12757962] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12757968] BioModels Database:BIOMD0000000651
[DatabaseIdentifier:12757970] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12757956] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12757972] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12757976] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12757978] BioModels Database:BIOMD0000000399
[DatabaseIdentifier:12757980] BioModels Database:BIOMD0000000019
[DatabaseIdentifier:12757982] BioModels Database:BIOMD0000000424
[DatabaseIdentifier:12757984] BioModels Database:BIOMD0000000654
dbId
5673001
deleted
[Deleted:9028794] Deletion of instance: 197529
[Deleted:9608142] Deletion of instance: 197529
[Deleted:6798808] Deletion of instance: 109869
diseasePathways
[Pathway:R-HSA-9753510] Signaling by RAS GAP mutants - Homo sapiens
[Pathway:R-HSA-9753512] Signaling by RAS GTPase mutants - Homo sapiens
[Pathway:R-HSA-9649913] RAS GTPase cycle mutants - Homo sapiens
[Pathway:R-HSA-9649948] Signaling downstream of RAS mutants - Homo sapiens
[Pathway:R-HSA-6802949] Signaling by RAS mutants - Homo sapiens
[Pathway:R-HSA-9652817] Signaling by MAPK mutants - Homo sapiens
[Pathway:R-HSA-6802948] Signaling by high-kinase activity BRAF mutants - Homo sapiens
[Pathway:R-HSA-6802946] Signaling by moderate kinase activity BRAF mutants - Homo sapiens
[Pathway:R-HSA-9652169] Signaling by MAP2K mutants - Homo sapiens
[Pathway:R-HSA-9726840] SHOC2 M1731 mutant abolishes MRAS complex function - Homo sapiens
[Pathway:R-HSA-9726842] Gain-of-function MRAS complexes activate RAF signaling - Homo sapiens
[Pathway:R-HSA-9660537] Signaling by MRAS-complex mutants - Homo sapiens
[Pathway:R-HSA-6802955] Paradoxical activation of RAF signaling by kinase inactive BRAF - Homo sapiens
[Pathway:R-HSA-9656223] Signaling by RAF1 mutants - Homo sapiens
[Pathway:R-HSA-6802953] RAS signaling downstream of NF1 loss-of-function variants - Homo sapiens
[Pathway:R-HSA-6802952] Signaling by BRAF and RAF1 fusions - Homo sapiens
[Pathway:R-HSA-6802957] Oncogenic MAPK signaling - Homo sapiens
displayName
RAF/MAP kinase cascade
doi
10.3180/R-HSA-5673001.9
edited
[InstanceEdit:5674528] Rothfels, Karen, 2015年02月12日
eventOf
[Pathway:R-HSA-5684996] MAPK1/MAPK3 signaling - Homo sapiens
figure
[Figure:1996283] /figures/Pathway_Illustrations/RASMAPK_72_oicr.png
goBiologicalProcess
[GO_BiologicalProcess:21714] MAPK cascade
hasDiagram
true
hasEHLD
false
hasEvent
[Pathway:R-HSA-9648002] RAS processing - Homo sapiens
[Reaction:R-HSA-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP - Homo sapiens
[Reaction:R-HSA-9649735] Intrinsic nucleotide exchange on RAS - Homo sapiens
[Reaction:R-HSA-5672965] RAS GEFs promote RAS nucleotide exchange - Homo sapiens
[Reaction:R-HSA-9658253] RAS:GTP binds PI3K - Homo sapiens
[Reaction:R-HSA-9660557] RAS:GTP binds RAL GDS proteins - Homo sapiens
[Pathway:R-HSA-5673000] RAF activation - Homo sapiens
[Pathway:R-HSA-5674135] MAP2K and MAPK activation - Homo sapiens
[Reaction:R-HSA-5674385] p-T,Y MAPKs dimerize - Homo sapiens
[BlackBoxEvent:R-HSA-5674387] Phosphorylated MAPKs translocate into the nucleus - Homo sapiens
[Reaction:R-HSA-5675206] PEA15 binds MAPK monomers and dimers - Homo sapiens
[Pathway:R-HSA-5675221] Negative regulation of MAPK pathway - Homo sapiens
[Pathway:R-HSA-5658442] Regulation of RAS by GAPs - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2023年06月07日
literatureReference
[LiteratureReference:5672144] "RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway
[LiteratureReference:5672517] RAF protein-serine/threonine kinases: structure and regulation
[LiteratureReference:208231] Integrating signals from RTKs to ERK/MAPK
[LiteratureReference:1497944] The RAF proteins take centre stage
[LiteratureReference:5673943] ERK1/2 MAP kinases: structure, function, and regulation
[LiteratureReference:5673960] MEK1/2 dual-specificity protein kinases: structure and regulation
[LiteratureReference:5683024] Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update
[LiteratureReference:5683022] MAP kinases and the control of nuclear events
[LiteratureReference:5683028] The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation
[LiteratureReference:5672150] Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
[LiteratureReference:5673962] Protein scaffolds in MAP kinase signalling
[LiteratureReference:5672236] Mutations of the BRAF gene in human cancer
[LiteratureReference:5683027] Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
[LiteratureReference:5683020] BRAFV600E: implications for carcinogenesis and molecular therapy
maxDepth
4
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
RAF/MAP kinase cascade
orthologousEvent
[Pathway:R-RNO-5673001] RAF/MAP kinase cascade - Rattus norvegicus
[Pathway:R-MMU-5673001] RAF/MAP kinase cascade - Mus musculus
[Pathway:R-SSC-5673001] RAF/MAP kinase cascade - Sus scrofa
[Pathway:R-CFA-5673001] RAF/MAP kinase cascade - Canis familiaris
[Pathway:R-BTA-5673001] RAF/MAP kinase cascade - Bos taurus
[Pathway:R-DRE-5673001] RAF/MAP kinase cascade - Danio rerio
[Pathway:R-XTR-5673001] RAF/MAP kinase cascade - Xenopus tropicalis
[Pathway:R-CEL-5673001] RAF/MAP kinase cascade - Caenorhabditis elegans
[Pathway:R-GGA-5673001] RAF/MAP kinase cascade - Gallus gallus
[Pathway:R-DME-5673001] RAF/MAP kinase cascade - Drosophila melanogaster
[Pathway:R-SPO-5673001] RAF/MAP kinase cascade - Schizosaccharomyces pombe
[Pathway:R-DDI-5673001] RAF/MAP kinase cascade - Dictyostelium discoideum
[Pathway:R-SCE-5673001] RAF/MAP kinase cascade - Saccharomyces cerevisiae
[Pathway:R-PFA-5673001] RAF/MAP kinase cascade - Plasmodium falciparum
precedingEvent
[Reaction:R-HSA-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Homo sapiens
[BlackBoxEvent:R-HSA-9606784] Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 - Homo sapiens
[Reaction:R-HSA-9604969] Active FLT3 binds PTPN11 - Homo sapiens
releaseDate
2015年06月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5690572] Roskoski, Robert Jr, 2015年04月28日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5673001
summation
[Summation:5683030] The RAS-RAF-MEK-ERK pathway regulates processes such as prol...
updateTrackers
[UpdateTracker:9835696] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v85:[updateIndirectRLE]
[UpdateTracker:9782910] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v58:[updateIndirectRLE]
[UpdateTracker:9783648] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v56:[modifyText]
[UpdateTracker:9776933] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v73:[addHasEvent, updateContainedPathway]
[UpdateTracker:9783801] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v55:[updateIndirectRLE]
[UpdateTracker:9775877] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v78:[updateIndirectRLE]
[UpdateTracker:9778933] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v67:[updateIndirectRLE]
[UpdateTracker:9777599] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v70:[updateIndirectRLE]
[UpdateTracker:9780602] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v62:[updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-5684996] MAPK1/MAPK3 signaling
(hasEncapsulatedEvent)
[Pathway:R-HSA-2586552] Signaling by Leptin
[Pathway:R-HSA-201556] Signaling by ALK
[Pathway:R-HSA-9842663] Signaling by LTK
[Pathway:R-HSA-9607240] FLT3 Signaling
[Pathway:R-HSA-8853659] RET signaling
[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
[Pathway:R-HSA-9648002] RAS processing
[Pathway:R-HSA-1227986] Signaling by ERBB2
[Pathway:R-HSA-6806834] Signaling by MET
[Pathway:R-HSA-1236394] Signaling by ERBB4
[Pathway:R-HSA-1433557] Signaling by SCF-KIT
[Pathway:R-HSA-186797] Signaling by PDGF
[Pathway:R-HSA-194138] Signaling by VEGF
[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2
[Pathway:R-HSA-451927] Interleukin-2 family signaling
[Pathway:R-HSA-5654736] Signaling by FGFR1
[Pathway:R-HSA-5654743] Signaling by FGFR4
[Pathway:R-HSA-881907] Gastrin-CREB signalling pathway via PKC and MAPK
[Pathway:R-HSA-2454202] Fc epsilon receptor (FCERI) signaling
[Pathway:R-HSA-74752] Signaling by Insulin receptor
[Pathway:R-HSA-5654741] Signaling by FGFR3
[Pathway:R-HSA-177929] Signaling by EGFR
[Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling
[Pathway:R-HSA-5654738] Signaling by FGFR2
[Pathway:R-HSA-187037] Signaling by NTRK1 (TRKA)
[Pathway:R-HSA-2404192] Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
[Pathway:R-HSA-442755] Activation of NMDA receptors and postsynaptic events
[Pathway:R-HSA-2172127] DAP12 interactions
[Pathway:R-HSA-8848021] Signaling by PTK6
[Pathway:R-HSA-9009391] Extra-nuclear estrogen signaling
[Pathway:R-HSA-9034015] Signaling by NTRK3 (TRKC)
[Pathway:R-HSA-9006115] Signaling by NTRK2 (TRKB)
[Pathway:R-HSA-375165] NCAM signaling for neurite out-growth
(normalPathway)
[Pathway:R-HSA-9753510] Signaling by RAS GAP mutants
[Pathway:R-HSA-9753512] Signaling by RAS GTPase mutants
[Pathway:R-HSA-9649913] RAS GTPase cycle mutants
[Pathway:R-HSA-9649948] Signaling downstream of RAS mutants
[Pathway:R-HSA-6802949] Signaling by RAS mutants
[Pathway:R-HSA-9652817] Signaling by MAPK mutants
[Pathway:R-HSA-6802948] Signaling by high-kinase activity BRAF mutants
[Pathway:R-HSA-6802946] Signaling by moderate kinase activity BRAF mutants
[Pathway:R-HSA-9652169] Signaling by MAP2K mutants
[Pathway:R-HSA-9726840] SHOC2 M1731 mutant abolishes MRAS complex function
[Pathway:R-HSA-9726842] Gain-of-function MRAS complexes activate RAF signaling
[Pathway:R-HSA-9660537] Signaling by MRAS-complex mutants
[Pathway:R-HSA-6802955] Paradoxical activation of RAF signaling by kinase inactive BRAF
[Pathway:R-HSA-9656223] Signaling by RAF1 mutants
[Pathway:R-HSA-6802953] RAS signaling downstream of NF1 loss-of-function variants
[Pathway:R-HSA-6802952] Signaling by BRAF and RAF1 fusions
[Pathway:R-HSA-6802957] Oncogenic MAPK signaling
(replacementInstances)
[Deleted:9028794] Deletion of instance: 197529
[Deleted:9608142] Deletion of instance: 197529
[Deleted:6798808] Deletion of instance: 109869
(updatedInstance)
[UpdateTracker:9835696] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v85:[updateIndirectRLE]
[UpdateTracker:9782910] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v58:[updateIndirectRLE]
[UpdateTracker:9783648] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v56:[modifyText]
[UpdateTracker:9776933] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v73:[addHasEvent, updateContainedPathway]
[UpdateTracker:9783801] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v55:[updateIndirectRLE]
[UpdateTracker:9775877] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v78:[updateIndirectRLE]
[UpdateTracker:9778933] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v67:[updateIndirectRLE]
[UpdateTracker:9777599] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v70:[updateIndirectRLE]
[UpdateTracker:9780602] Update Tracker - [Pathway:5673001] RAF/MAP kinase cascade - v62:[updateIndirectRLE]
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