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Entries
Extra-nuclear estrogen signaling
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authored
[InstanceEdit:9024061] Rothfels, Karen, 2017年09月29日
created
[InstanceEdit:9009390] Rothfels, Karen, 2017年06月16日
dbId
9009391
displayName
Extra-nuclear estrogen signaling
doi
10.3180/R-HSA-9009391.2
eventOf
[Pathway:R-HSA-8939211] ESR-mediated signaling - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-9632182] PRMT1 methylates ESRs - Homo sapiens
[Reaction:R-HSA-9021050] HSBP1 oligomer binds ESRs - Homo sapiens
[Reaction:R-HSA-9021072] ZDHHC7, ZDHHC21 palmitoylate ESR1 - Homo sapiens
[Reaction:R-HSA-9021068] PalmS-ESRs bind CAVs - Homo sapiens
[BlackBoxEvent:R-HSA-9021079] PalmS-ESRs:CAVs translocate to plasma membrane - Homo sapiens
[Reaction:R-HSA-9021170] Estrogen stimulates dimerization of plasma membrane estrogen receptors - Homo sapiens
[Reaction:R-HSA-9633044] ESR binds STRN - Homo sapiens
[BlackBoxEvent:R-HSA-9027670] ESTG binding induces ESR depalmitoylation - Homo sapiens
[Reaction:R-HSA-9021601] Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG - Homo sapiens
[Reaction:R-HSA-9021600] G-proteins dissociate from plasma-membrane estrogen receptors - Homo sapiens
[Reaction:R-HSA-9021596] Membrane estrogen receptors bind SRC - Homo sapiens
[Reaction:R-HSA-9021609] ESR-associated SRC autophosphorylates - Homo sapiens
[Reaction:R-HSA-9021660] PI3K binds membrane-associated estrogen receptors - Homo sapiens
[Reaction:R-HSA-202127] eNOS synthesizes NO - Homo sapiens
[Reaction:R-HSA-9632412] PTK2 is recruited to methylated ESR1 - Homo sapiens
[Pathway:R-HSA-9634635] Estrogen-stimulated signaling through PRKCZ - Homo sapiens
[BlackBoxEvent:R-HSA-9634584] Estrogen receptor binds IGF1R and SHC1 in response to estrogen - Homo sapiens
[Reaction:R-HSA-9624272] MMPs cleave HB-EGF - Homo sapiens
[Reaction:R-HSA-9625482] PTK2 binds activated EGFR - Homo sapiens
[Reaction:R-HSA-9625487] PTK2 autophosphorylates downstream of EGFR - Homo sapiens
[Pathway:R-HSA-9634638] Estrogen-dependent nuclear events downstream of ESR-membrane signaling - Homo sapiens
[Reaction:R-HSA-9625814] SPHK1 phosphorylates sphingosine in response to E2 stimulation - Homo sapiens
[Reaction:R-HSA-9625813] S1P binds S1PR3 in response to E2 stimulation - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2023年03月29日
literatureReference
[LiteratureReference:9020996] S-palmitoylation modulates human estrogen receptor-alpha functions
[LiteratureReference:9021000] Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol
[LiteratureReference:9644985] S-palmitoylation modulates estrogen receptor alpha localization and functions
[LiteratureReference:9644989] Steroid hormone rapid signaling: the pivotal role of S-palmitoylation
[LiteratureReference:9021013] A conserved mechanism for steroid receptor translocation to the plasma membrane
[LiteratureReference:9021009] DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors
[LiteratureReference:9632130] Regulation of estrogen rapid signaling through arginine methylation by PRMT1
[LiteratureReference:9022229] Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications
[LiteratureReference:9632146] Cracking the estrogen receptor's posttranslational code in breast tumors
[LiteratureReference:9632155] Extranuclear steroid receptors: nature and actions
[LiteratureReference:9632169] Roles for oestrogen receptor ? in adult brain function
[LiteratureReference:9632158] Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer
[LiteratureReference:9632165] Nongenomic actions of steroid hormones
[LiteratureReference:9007401] Rapid steroid hormone actions via membrane receptors
[LiteratureReference:9631708] Scaffolding proteins mediating membrane-initiated extra-nuclear actions of estrogen receptor
[LiteratureReference:9632149] Crossroads of estrogen receptor and NF-kappaB signaling
[LiteratureReference:9644987] Steroid hormone interactions with target cells: cross talk between membrane and nuclear pathways
[LiteratureReference:9632160] Minireview: Recent advances in extranuclear steroid receptor actions
[LiteratureReference:9027660] Palmitoylation regulates 17?-estradiol-induced estrogen receptor-? degradation and transcriptional activity
[LiteratureReference:9644984] Fibronectin rescues estrogen receptor ? from lysosomal degradation in breast cancer cells
maxDepth
3
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
Extra-nuclear estrogen signaling
orthologousEvent
[Pathway:R-CEL-9009391] Extra-nuclear estrogen signaling - Caenorhabditis elegans
[Pathway:R-PFA-9009391] Extra-nuclear estrogen signaling - Plasmodium falciparum
[Pathway:R-SCE-9009391] Extra-nuclear estrogen signaling - Saccharomyces cerevisiae
[Pathway:R-SPO-9009391] Extra-nuclear estrogen signaling - Schizosaccharomyces pombe
[Pathway:R-DDI-9009391] Extra-nuclear estrogen signaling - Dictyostelium discoideum
[Pathway:R-DME-9009391] Extra-nuclear estrogen signaling - Drosophila melanogaster
[Pathway:R-GGA-9009391] Extra-nuclear estrogen signaling - Gallus gallus
[Pathway:R-XTR-9009391] Extra-nuclear estrogen signaling - Xenopus tropicalis
[Pathway:R-DRE-9009391] Extra-nuclear estrogen signaling - Danio rerio
[Pathway:R-SSC-9009391] Extra-nuclear estrogen signaling - Sus scrofa
[Pathway:R-BTA-9009391] Extra-nuclear estrogen signaling - Bos taurus
[Pathway:R-CFA-9009391] Extra-nuclear estrogen signaling - Canis familiaris
[Pathway:R-RNO-9009391] Extra-nuclear estrogen signaling - Rattus norvegicus
[Pathway:R-MMU-9009391] Extra-nuclear estrogen signaling - Mus musculus
releaseDate
2019年03月20日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9637806] Levin, Ellis R, 2019年02月19日
[InstanceEdit:9645002] Marino, Maria, 2019年04月24日
[InstanceEdit:9645003] Acconcia, Filippo, 2019年04月24日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9009391
summation
[Summation:9631715] In addition to its well-characterized role in estrogen-depen...
updateTrackers
[UpdateTracker:9775461] Update Tracker - [Pathway:9009391] Extra-nuclear estrogen signaling - v79:[addHasEvent]
[UpdateTracker:9846731] Update Tracker - [Pathway:9009391] Extra-nuclear estrogen signaling - v84:[updateIndirectRLE]
[UpdateTracker:9864261] Update Tracker - [Pathway:9009391] Extra-nuclear estrogen signaling - v88:[updateIndirectRLE]
[UpdateTracker:9777796] Update Tracker - [Pathway:9009391] Extra-nuclear estrogen signaling - v69:[addLiteratureReference, modifyText, updateContainedRLE, updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-8939211] ESR-mediated signaling
(hasEncapsulatedEvent)
[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
(updatedInstance)
[UpdateTracker:9775461] Update Tracker - [Pathway:9009391] Extra-nuclear estrogen signaling - v79:[addHasEvent]
[UpdateTracker:9846731] Update Tracker - [Pathway:9009391] Extra-nuclear estrogen signaling - v84:[updateIndirectRLE]
[UpdateTracker:9864261] Update Tracker - [Pathway:9009391] Extra-nuclear estrogen signaling - v88:[updateIndirectRLE]
[UpdateTracker:9777796] Update Tracker - [Pathway:9009391] Extra-nuclear estrogen signaling - v69:[addLiteratureReference, modifyText, updateContainedRLE, updateIndirectRLE]
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