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Schema
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Reaction
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Entries
eNOS synthesizes NO
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authored
[InstanceEdit:202104] Hemish, J, 2007年10月19日 18:00:42
catalystActivity
[CatalystActivity:203600] nitric-oxide synthase activity of p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]
catalystActivityReference
[CatalystActivityReference:9911158] nitric-oxide synthase activity of p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:202104] Hemish, J, 2007年10月19日 18:00:42
crossReference
[DatabaseIdentifier:9911125] RHEA:19898
dbId
202127
displayName
eNOS synthesizes NO
eventOf
[Pathway:R-HSA-203615] eNOS activation - Homo sapiens
[Pathway:R-HSA-9009391] Extra-nuclear estrogen signaling - Homo sapiens
[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability - Homo sapiens
followingEvent
[Reaction:R-HSA-1497878] Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-) - Homo sapiens
input
[SimpleEntity:R-ALL-70106] H+ [cytosol]
2 ×
[SimpleEntity:R-ALL-29468] L-Arg [cytosol]
3 ×
[SimpleEntity:R-ALL-29364] NADPH [cytosol]
[SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:202106] Nitric oxide: a physiologic messenger molecule
[LiteratureReference:202120] Nitric Oxide as a Unique Bioactive Signaling Messenger in Physiology and Pathophysiology
[LiteratureReference:203616] Determination of nitric oxide synthase cofactors: heme, FAD, FMN, and tetrahydrobiopterin
[LiteratureReference:203569] Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization
[LiteratureReference:9911175] Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase
maxDepth
1
modified
[InstanceEdit:11064438] Weiser, Joel, 2025年08月28日
name
eNOS synthesizes NO
H(+) + 2 L-arginine + 3 NADPH + 4 O2 => 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide
NO biosynthesis
orthologousEvent
[Reaction:R-PFA-202127] eNOS synthesizes NO - Plasmodium falciparum
[Reaction:R-SCE-202127] eNOS synthesizes NO - Saccharomyces cerevisiae
[Reaction:R-SPO-202127] eNOS synthesizes NO - Schizosaccharomyces pombe
[Reaction:R-DDI-202127] eNOS synthesizes NO - Dictyostelium discoideum
[Reaction:R-CEL-202127] eNOS synthesizes NO - Caenorhabditis elegans
[Reaction:R-DME-202127] eNOS synthesizes NO - Drosophila melanogaster
[Reaction:R-GGA-202127] eNOS synthesizes NO - Gallus gallus
[Reaction:R-SSC-202127] eNOS synthesizes NO - Sus scrofa
[Reaction:R-BTA-202127] eNOS synthesizes NO - Bos taurus
[Reaction:R-RNO-202127] eNOS synthesizes NO - Rattus norvegicus
[Reaction:R-MMU-202127] eNOS synthesizes NO - Mus musculus
output
4 ×
[SimpleEntity:R-ALL-29356] H2O [cytosol]
2 ×
[SimpleEntity:R-ALL-29968] L-Cit [cytosol]
3 ×
[SimpleEntity:R-ALL-29366] NADP+ [cytosol]
2 ×
[SimpleEntity:R-ALL-202124] NO [cytosol]
precedingEvent
[Reaction:R-HSA-1497784] The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle - Homo sapiens
previousReviewStatus
[ReviewStatus:9821385] four stars
regulatedBy
[NegativeRegulation:R-HSA-6783968] Negative regulation by 'ADMA [cytosol]'
releaseDate
2008年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:215470] Enikolopov, G, 2008年02月28日 17:52:44
[InstanceEdit:9917333] Hill, David P, 2024年08月02日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-202127
summation
[Summation:202119] Nitric oxide (NO) is produced from L-arginine by the family ...
updateTrackers
[UpdateTracker:9784171] Update Tracker - [Reaction:202127] eNOS synthesizes NO - v54:[addRegulator]
[UpdateTracker:9789460] Update Tracker - [Reaction:202127] eNOS synthesizes NO - v38:[modifyText]
[UpdateTracker:9919399] Update Tracker - [Reaction:202127] eNOS synthesizes NO - v90:[modifyText, removeInput, removeLiteratureReference, removeOutput]
Referrals
(updatedInstance)
[UpdateTracker:9784171] Update Tracker - [Reaction:202127] eNOS synthesizes NO - v54:[addRegulator]
[UpdateTracker:9789460] Update Tracker - [Reaction:202127] eNOS synthesizes NO - v38:[modifyText]
[UpdateTracker:9919399] Update Tracker - [Reaction:202127] eNOS synthesizes NO - v90:[modifyText, removeInput, removeLiteratureReference, removeOutput]
(hasEvent)
[Pathway:R-HSA-9009391] Extra-nuclear estrogen signaling
[Pathway:R-HSA-5218920] VEGFR2 mediated vascular permeability
[Pathway:R-HSA-203615] eNOS activation
(precedingEvent)
[Reaction:R-HSA-1497878] Superoxide reacts rapidly with NO to form peroxynitrite (ONOO-)
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