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Schema
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Pathway
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Entries
Negative regulation of MAPK pathway
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authored
[InstanceEdit:5674528] Rothfels, Karen, 2015年02月12日
created
[InstanceEdit:5675222] Rothfels, Karen, 2015年02月15日
crossReference
[DatabaseIdentifier:12758008] BioModels Database:BIOMD0000000427
[DatabaseIdentifier:12757950] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:12757960] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12757962] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12758010] BioModels Database:BIOMD0000000832
[DatabaseIdentifier:12757964] BioModels Database:BIOMD0000000659
[DatabaseIdentifier:12757966] BioModels Database:BIOMD0000000149
[DatabaseIdentifier:12757882] BioModels Database:BIOMD0000000664
[DatabaseIdentifier:12757968] BioModels Database:BIOMD0000000651
[DatabaseIdentifier:12757970] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12757956] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12757972] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12757974] BioModels Database:BIOMD0000000288
[DatabaseIdentifier:12757976] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12757978] BioModels Database:BIOMD0000000399
[DatabaseIdentifier:12757980] BioModels Database:BIOMD0000000019
[DatabaseIdentifier:12757928] BioModels Database:BIOMD0000000477
[DatabaseIdentifier:12757982] BioModels Database:BIOMD0000000424
[DatabaseIdentifier:12757984] BioModels Database:BIOMD0000000654
dbId
5675221
displayName
Negative regulation of MAPK pathway
edited
[InstanceEdit:5674528] Rothfels, Karen, 2015年02月12日
eventOf
[Pathway:R-HSA-5673001] RAF/MAP kinase cascade - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-5674140] PAQR3 binds inactive RAFs - Homo sapiens
[Pathway:R-HSA-5674499] Negative feedback regulation of MAPK pathway - Homo sapiens
[Reaction:R-HSA-5675417] PEBP1 binds activated RAF1 - Homo sapiens
[Reaction:R-HSA-5675433] PP5 dephosphorylates RAF1 S338 - Homo sapiens
[Reaction:R-HSA-5675431] PP2A dephosphorylates RAF1 - Homo sapiens
[Reaction:R-HSA-5675376] Cytosolic DUSPs dephosphorylate MAPKs - Homo sapiens
[Reaction:R-HSA-5675373] Nuclear DUSPs dephosphorylate MAPKs - Homo sapiens
[Reaction:R-HSA-5674019] BRAP binds KSR1:MARK3 - Homo sapiens
[Reaction:R-HSA-5674018] BRAP binds RAS:GTP - Homo sapiens
[Reaction:R-HSA-5674022] BRAP autoubiquitinates - Homo sapiens
[Reaction:R-HSA-9635743] PTPN7 binds p-T,Y-MAPK - Homo sapiens
[Reaction:R-HSA-9635739] PTPN7 dephosphorylates p-T,Y-MAPKs - Homo sapiens
[Reaction:R-HSA-8867654] PTPN3 binds p-T183,Y185 MAPK12 - Homo sapiens
[Reaction:R-HSA-8867658] PTPN3 dephosphorylates MAPK12 - Homo sapiens
[Reaction:R-HSA-8868118] MAPK12 phosphorylates PTPN3 - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2020年06月17日
literatureReference
[LiteratureReference:5675123] Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway
[LiteratureReference:5672246] Raf family kinases: old dogs have learned new tricks
[LiteratureReference:5675171] Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5
[LiteratureReference:5674456] Regulation of Raf-1 by direct feedback phosphorylation
[LiteratureReference:5673933] A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal
[LiteratureReference:5675142] Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
[LiteratureReference:5658234] Nonredundant functions for Ras GTPase-activating proteins in tissue homeostasis
maxDepth
3
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
Negative regulation of MAPK pathway
orthologousEvent
[Pathway:R-MMU-5675221] Negative regulation of MAPK pathway - Mus musculus
[Pathway:R-RNO-5675221] Negative regulation of MAPK pathway - Rattus norvegicus
[Pathway:R-CFA-5675221] Negative regulation of MAPK pathway - Canis familiaris
[Pathway:R-BTA-5675221] Negative regulation of MAPK pathway - Bos taurus
[Pathway:R-SSC-5675221] Negative regulation of MAPK pathway - Sus scrofa
[Pathway:R-DRE-5675221] Negative regulation of MAPK pathway - Danio rerio
[Pathway:R-XTR-5675221] Negative regulation of MAPK pathway - Xenopus tropicalis
[Pathway:R-GGA-5675221] Negative regulation of MAPK pathway - Gallus gallus
[Pathway:R-DME-5675221] Negative regulation of MAPK pathway - Drosophila melanogaster
[Pathway:R-CEL-5675221] Negative regulation of MAPK pathway - Caenorhabditis elegans
[Pathway:R-DDI-5675221] Negative regulation of MAPK pathway - Dictyostelium discoideum
[Pathway:R-SPO-5675221] Negative regulation of MAPK pathway - Schizosaccharomyces pombe
[Pathway:R-SCE-5675221] Negative regulation of MAPK pathway - Saccharomyces cerevisiae
[Pathway:R-PFA-5675221] Negative regulation of MAPK pathway - Plasmodium falciparum
releaseDate
2015年06月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5690572] Roskoski, Robert Jr, 2015年04月28日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5675221
summation
[Summation:5675209] The duration and extent of activated MAPK signaling is regul...
updateTrackers
[UpdateTracker:9776934] Update Tracker - [Pathway:5675221] Negative regulation of MAPK pathway - v73:[addHasEvent]
Referrals
(hasEvent)
[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
(updatedInstance)
[UpdateTracker:9776934] Update Tracker - [Pathway:5675221] Negative regulation of MAPK pathway - v73:[addHasEvent]
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