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Entries
Signaling by EGFR
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authored
[InstanceEdit:215493] Jassal, B, Castagnoli, L, 2008年02月28日 00:00:00
created
[InstanceEdit:177921] Jassal, Bijay, 2006年04月11日
crossReference
[DatabaseIdentifier:12757950] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:12757960] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12757962] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12758066] BioModels Database:BIOMD0000000594
[DatabaseIdentifier:12757970] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12758014] BioModels Database:BIOMD0000000466
[DatabaseIdentifier:12758068] BioModels Database:BIOMD0000000223
[DatabaseIdentifier:12757956] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12757972] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12758070] BioModels Database:BIOMD0000000595
[DatabaseIdentifier:12757976] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12758018] BioModels Database:BIOMD0000000468
[DatabaseIdentifier:12757978] BioModels Database:BIOMD0000000399
[DatabaseIdentifier:12757980] BioModels Database:BIOMD0000000019
[DatabaseIdentifier:12757928] BioModels Database:BIOMD0000000477
[DatabaseIdentifier:12757984] BioModels Database:BIOMD0000000654
dbId
177929
diseasePathways
[Pathway:R-HSA-5638302] Signaling by Overexpressed Wild-Type EGFR in Cancer - Homo sapiens
[Pathway:R-HSA-5637812] Signaling by EGFRvIII in Cancer - Homo sapiens
[Pathway:R-HSA-5637815] Signaling by Ligand-Responsive EGFR Variants in Cancer - Homo sapiens
displayName
Signaling by EGFR
doi
10.3180/R-HSA-177929.5
edited
[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011年08月25日
eventOf
[Pathway:R-HSA-9006934] Signaling by Receptor Tyrosine Kinases - Homo sapiens
figure
[Figure:1996282] /figures/Pathway_Illustrations/EGFR_72_oicr.png
goBiologicalProcess
[GO_BiologicalProcess:8092] epidermal growth factor receptor signaling pathway
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-177946] Pro-EGF is cleaved to form mature EGF - Homo sapiens
[Reaction:R-HSA-9674531] AAMP binds EGFR - Homo sapiens
[Reaction:R-HSA-9851407] FAM83B, (FAM83A, FAM83D) bind EGFR - Homo sapiens
[Reaction:R-HSA-177942] EGFR binds EGF ligand - Homo sapiens
[Reaction:R-HSA-177922] EGFR dimerization - Homo sapiens
[Reaction:R-HSA-177934] EGFR autophosphorylation - Homo sapiens
[Reaction:R-HSA-177937] Phosphorylation of EGFR by SRC kinase - Homo sapiens
[Pathway:R-HSA-212718] EGFR interacts with phospholipase C-gamma - Homo sapiens
[Pathway:R-HSA-179812] GRB2 events in EGFR signaling - Homo sapiens
[Pathway:R-HSA-180336] SHC1 events in EGFR signaling - Homo sapiens
[Pathway:R-HSA-180292] GAB1 signalosome - Homo sapiens
[Pathway:R-HSA-182971] EGFR downregulation - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2023年03月29日
literatureReference
[LiteratureReference:188592] Review of epidermal growth factor receptor biology
[LiteratureReference:188596] EGF receptor
[LiteratureReference:188660] Employment of the epidermal growth factor receptor in growth factor-independent signaling pathways
[LiteratureReference:188661] Ligand-induced, receptor-mediated dimerization and activation of EGF receptor
[LiteratureReference:1497911] Feedback regulation of EGFR signalling: decision making by early and delayed loops
[LiteratureReference:9852947] Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer
[LiteratureReference:9852956] EGFR in Cancer: Signaling Mechanisms, Drugs, and Acquired Resistance
[LiteratureReference:9852951] FAM83 proteins: Fostering new interactions to drive oncogenic signaling and therapeutic resistance
maxDepth
3
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Signaling by EGFR
Epidermal Growth Factor Receptor (EGFR) signaling
orthologousEvent
[Pathway:R-MMU-177929] Signaling by EGFR - Mus musculus
[Pathway:R-RNO-177929] Signaling by EGFR - Rattus norvegicus
[Pathway:R-CFA-177929] Signaling by EGFR - Canis familiaris
[Pathway:R-BTA-177929] Signaling by EGFR - Bos taurus
[Pathway:R-SSC-177929] Signaling by EGFR - Sus scrofa
[Pathway:R-DRE-177929] Signaling by EGFR - Danio rerio
[Pathway:R-XTR-177929] Signaling by EGFR - Xenopus tropicalis
[Pathway:R-DME-177929] Signaling by EGFR - Drosophila melanogaster
[Pathway:R-GGA-177929] Signaling by EGFR - Gallus gallus
[Pathway:R-CEL-177929] Signaling by EGFR - Caenorhabditis elegans
previousReviewStatus
[ReviewStatus:9821384] two stars
releaseDate
2007年02月20日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:215425] Muthuswamy, S, Heldin, CH, 2008年02月28日
[InstanceEdit:9852954] Hill, David P, 2023年11月08日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-177929
summation
[Summation:188591] The epidermal growth factor receptor (EGFR) is one member of...
updateTrackers
[UpdateTracker:9846816] Update Tracker - [Pathway:177929] Signaling by EGFR - v84:[modifyText, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9782804] Update Tracker - [Pathway:177929] Signaling by EGFR - v58:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9791694] Update Tracker - [Pathway:177929] Signaling by EGFR - v27:[updateContainedPathway]
[UpdateTracker:9780015] Update Tracker - [Pathway:177929] Signaling by EGFR - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788825] Update Tracker - [Pathway:177929] Signaling by EGFR - v40:[updateIndirectRLE]
[UpdateTracker:9778202] Update Tracker - [Pathway:177929] Signaling by EGFR - v68:[updateIndirectRLE]
[UpdateTracker:9784702] Update Tracker - [Pathway:177929] Signaling by EGFR - v53:[updateContainedPathway]
[UpdateTracker:9781507] Update Tracker - [Pathway:177929] Signaling by EGFR - v61:[updateContainedPathway]
[UpdateTracker:9778794] Update Tracker - [Pathway:177929] Signaling by EGFR - v67:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9780858] Update Tracker - [Pathway:177929] Signaling by EGFR - v62:[updateContainedPathway]
[UpdateTracker:9853183] Update Tracker - [Pathway:177929] Signaling by EGFR - v87:[addHasEvent, addLiteratureReference, modifyText, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9788903] Update Tracker - [Pathway:177929] Signaling by EGFR - v39:[updateIndirectRLE]
[UpdateTracker:9792187] Update Tracker - [Pathway:177929] Signaling by EGFR - v23:[updateContainedRLE]
[UpdateTracker:9781793] Update Tracker - [Pathway:177929] Signaling by EGFR - v60:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9775573] Update Tracker - [Pathway:177929] Signaling by EGFR - v78:[updateIndirectRLE]
[UpdateTracker:9788412] Update Tracker - [Pathway:177929] Signaling by EGFR - v42:[updateContainedPathway]
[UpdateTracker:9784246] Update Tracker - [Pathway:177929] Signaling by EGFR - v54:[updateIndirectRLE]
[UpdateTracker:9789494] Update Tracker - [Pathway:177929] Signaling by EGFR - v38:[modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9783551] Update Tracker - [Pathway:177929] Signaling by EGFR - v56:[updateContainedPathway]
[UpdateTracker:9783220] Update Tracker - [Pathway:177929] Signaling by EGFR - v57:[updateContainedPathway]
[UpdateTracker:9791961] Update Tracker - [Pathway:177929] Signaling by EGFR - v24:[addHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9777200] Update Tracker - [Pathway:177929] Signaling by EGFR - v72:[addHasEvent]
Referrals
(hasEvent)
[Pathway:R-HSA-9006934] Signaling by Receptor Tyrosine Kinases
(hasEncapsulatedEvent)
[Pathway:R-HSA-8848021] Signaling by PTK6
[Pathway:R-HSA-9009391] Extra-nuclear estrogen signaling
[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
(normalPathway)
[Pathway:R-HSA-5638302] Signaling by Overexpressed Wild-Type EGFR in Cancer
[Pathway:R-HSA-5637812] Signaling by EGFRvIII in Cancer
[Pathway:R-HSA-5637815] Signaling by Ligand-Responsive EGFR Variants in Cancer
(updatedInstance)
[UpdateTracker:9846816] Update Tracker - [Pathway:177929] Signaling by EGFR - v84:[modifyText, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9782804] Update Tracker - [Pathway:177929] Signaling by EGFR - v58:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9791694] Update Tracker - [Pathway:177929] Signaling by EGFR - v27:[updateContainedPathway]
[UpdateTracker:9780015] Update Tracker - [Pathway:177929] Signaling by EGFR - v64:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788825] Update Tracker - [Pathway:177929] Signaling by EGFR - v40:[updateIndirectRLE]
[UpdateTracker:9778202] Update Tracker - [Pathway:177929] Signaling by EGFR - v68:[updateIndirectRLE]
[UpdateTracker:9784702] Update Tracker - [Pathway:177929] Signaling by EGFR - v53:[updateContainedPathway]
[UpdateTracker:9781507] Update Tracker - [Pathway:177929] Signaling by EGFR - v61:[updateContainedPathway]
[UpdateTracker:9778794] Update Tracker - [Pathway:177929] Signaling by EGFR - v67:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9780858] Update Tracker - [Pathway:177929] Signaling by EGFR - v62:[updateContainedPathway]
[UpdateTracker:9853183] Update Tracker - [Pathway:177929] Signaling by EGFR - v87:[addHasEvent, addLiteratureReference, modifyText, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9788903] Update Tracker - [Pathway:177929] Signaling by EGFR - v39:[updateIndirectRLE]
[UpdateTracker:9792187] Update Tracker - [Pathway:177929] Signaling by EGFR - v23:[updateContainedRLE]
[UpdateTracker:9781793] Update Tracker - [Pathway:177929] Signaling by EGFR - v60:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9775573] Update Tracker - [Pathway:177929] Signaling by EGFR - v78:[updateIndirectRLE]
[UpdateTracker:9788412] Update Tracker - [Pathway:177929] Signaling by EGFR - v42:[updateContainedPathway]
[UpdateTracker:9784246] Update Tracker - [Pathway:177929] Signaling by EGFR - v54:[updateIndirectRLE]
[UpdateTracker:9789494] Update Tracker - [Pathway:177929] Signaling by EGFR - v38:[modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9783551] Update Tracker - [Pathway:177929] Signaling by EGFR - v56:[updateContainedPathway]
[UpdateTracker:9783220] Update Tracker - [Pathway:177929] Signaling by EGFR - v57:[updateContainedPathway]
[UpdateTracker:9791961] Update Tracker - [Pathway:177929] Signaling by EGFR - v24:[addHasEvent, modifyText, updateContainedRLE]
[UpdateTracker:9777200] Update Tracker - [Pathway:177929] Signaling by EGFR - v72:[addHasEvent]
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