Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Pathway
>
Entries
EGFR downregulation
Show undefined attributes
Go to Details
authored
[InstanceEdit:188408] Castagnoli, L, 2006年10月10日 13:09:34
created
[InstanceEdit:183010] Jassal, B, 2006年07月21日 10:19:47
crossReference
[DatabaseIdentifier:12757950] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:12758066] BioModels Database:BIOMD0000000594
[DatabaseIdentifier:12758068] BioModels Database:BIOMD0000000223
[DatabaseIdentifier:12757956] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12758070] BioModels Database:BIOMD0000000595
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12757978] BioModels Database:BIOMD0000000399
[DatabaseIdentifier:12757980] BioModels Database:BIOMD0000000019
[DatabaseIdentifier:12757928] BioModels Database:BIOMD0000000477
dbId
182971
displayName
EGFR downregulation
doi
10.3180/react_12484.1
eventOf
[Pathway:R-HSA-177929] Signaling by EGFR - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:8094] negative regulation of epidermal growth factor receptor signaling pathway
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-183055] Binding of CBL to EGFR - Homo sapiens
[Reaction:R-HSA-182969] Phosphorylation of CBL (EGFR:CBL) - Homo sapiens
[Reaction:R-HSA-183089] CBL binds and ubiquitinates phosphorylated Sprouty - Homo sapiens
[Reaction:R-HSA-182993] Ubiquitination of stimulated EGFR (CBL) - Homo sapiens
[Reaction:R-HSA-183052] CBL binds to GRB2 - Homo sapiens
[Reaction:R-HSA-183067] Localization of CBL:GRB2 to the membrane - Homo sapiens
[Reaction:R-HSA-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Homo sapiens
[Reaction:R-HSA-183036] Ubiquitination of stimulated EGFR (CBL:GRB2) - Homo sapiens
[BlackBoxEvent:R-HSA-182988] Sprouty lures CBL away from EGFR - Homo sapiens
[Reaction:R-HSA-183094] CDC42:GTP binds CBL:Beta-Pix - Homo sapiens
[Reaction:R-HSA-183002] Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 - Homo sapiens
[Reaction:R-HSA-8951490] CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 - Homo sapiens
[Reaction:R-HSA-183084] CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix - Homo sapiens
[Reaction:R-HSA-182994] Assembly of EGFR complex in clathrin-coated vesicles - Homo sapiens
[Reaction:R-HSA-183072] EGFR non-clathrin mediated endocytosis - Homo sapiens
[Reaction:R-HSA-183051] CBL ubiquitinates Sprouty - Homo sapiens
[Reaction:R-HSA-182986] CBL-mediated ubiquitination of CIN85 - Homo sapiens
[Reaction:R-HSA-182990] Sprouty sequesters CBL away from active EGFR - Homo sapiens
[Reaction:R-HSA-8864029] PTPN12 dephosphorylates EGFR at Y1172 (Y1148) - Homo sapiens
[Reaction:R-HSA-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Homo sapiens
[Reaction:R-HSA-8867041] EGFR phosphorylates EPS15 - Homo sapiens
[Reaction:R-HSA-8867047] PTPN3 dephosphorylates EPS15 - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2023年03月29日
literatureReference
[LiteratureReference:188597] Mechanisms controlling EGF receptor endocytosis and degradation
[LiteratureReference:182974] Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases
[LiteratureReference:188598] Cbl: many adaptations to regulate protein tyrosine kinases
maxDepth
2
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
EGFR downregulation
orthologousEvent
[Pathway:R-MMU-182971] EGFR downregulation - Mus musculus
[Pathway:R-RNO-182971] EGFR downregulation - Rattus norvegicus
[Pathway:R-CFA-182971] EGFR downregulation - Canis familiaris
[Pathway:R-BTA-182971] EGFR downregulation - Bos taurus
[Pathway:R-SSC-182971] EGFR downregulation - Sus scrofa
[Pathway:R-DRE-182971] EGFR downregulation - Danio rerio
[Pathway:R-XTR-182971] EGFR downregulation - Xenopus tropicalis
[Pathway:R-GGA-182971] EGFR downregulation - Gallus gallus
[Pathway:R-DME-182971] EGFR downregulation - Drosophila melanogaster
[Pathway:R-CEL-182971] EGFR downregulation - Caenorhabditis elegans
releaseDate
2008年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:212476] Heldin, CH, 2008年02月12日 09:44:02
revised
[InstanceEdit:8869706] Chen, Guang-Chao, 2016年05月06日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-182971
summation
[Summation:186761] Regulation of receptor tyrosine kinase (RTK) activity is imp...
updateTrackers
[UpdateTracker:9775839] Update Tracker - [Pathway:182971] EGFR downregulation - v78:[updateContainedRLE]
[UpdateTracker:9784499] Update Tracker - [Pathway:182971] EGFR downregulation - v54:[updateContainedRLE]
[UpdateTracker:9782733] Update Tracker - [Pathway:182971] EGFR downregulation - v58:[addHasEvent, updateContainedRLE]
[UpdateTracker:9783206] Update Tracker - [Pathway:182971] EGFR downregulation - v57:[add_removeHasEvent]
[UpdateTracker:9781795] Update Tracker - [Pathway:182971] EGFR downregulation - v60:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779771] Update Tracker - [Pathway:182971] EGFR downregulation - v64:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9778781] Update Tracker - [Pathway:182971] EGFR downregulation - v67:[updateContainedRLE]
[UpdateTracker:9789223] Update Tracker - [Pathway:182971] EGFR downregulation - v38:[updateContainedRLE]
[UpdateTracker:9846598] Update Tracker - [Pathway:182971] EGFR downregulation - v84:[updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-177929] Signaling by EGFR
(updatedInstance)
[UpdateTracker:9775839] Update Tracker - [Pathway:182971] EGFR downregulation - v78:[updateContainedRLE]
[UpdateTracker:9784499] Update Tracker - [Pathway:182971] EGFR downregulation - v54:[updateContainedRLE]
[UpdateTracker:9782733] Update Tracker - [Pathway:182971] EGFR downregulation - v58:[addHasEvent, updateContainedRLE]
[UpdateTracker:9783206] Update Tracker - [Pathway:182971] EGFR downregulation - v57:[add_removeHasEvent]
[UpdateTracker:9781795] Update Tracker - [Pathway:182971] EGFR downregulation - v60:[addHasEvent, updateContainedRLE]
[UpdateTracker:9779771] Update Tracker - [Pathway:182971] EGFR downregulation - v64:[removeHasEvent, updateContainedRLE]
[UpdateTracker:9778781] Update Tracker - [Pathway:182971] EGFR downregulation - v67:[updateContainedRLE]
[UpdateTracker:9789223] Update Tracker - [Pathway:182971] EGFR downregulation - v38:[updateContainedRLE]
[UpdateTracker:9846598] Update Tracker - [Pathway:182971] EGFR downregulation - v84:[updateContainedRLE]
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル