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Schema
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Reaction
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Entries
EGFR phosphorylates EPS15
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authored
[InstanceEdit:8866957] Rothfels, Karen, 2016年04月05日
catalystActivity
[CatalystActivity:8867039] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:8867043] Rothfels, Karen, 2016年04月05日
dbId
8867041
displayName
EGFR phosphorylates EPS15
edited
[InstanceEdit:8866957] Rothfels, Karen, 2016年04月05日
eventOf
[Pathway:R-HSA-182971] EGFR downregulation - Homo sapiens
followingEvent
[Reaction:R-HSA-8867047] PTPN3 dephosphorylates EPS15 - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-8867034] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8866989] Tyrosine phosphorylation of Eps15 is required for ligand-regulated, but not constitutive, endocytosis
[LiteratureReference:8866987] Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment
[LiteratureReference:8866997] Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation
[LiteratureReference:8867017] Eps15: a multifunctional adaptor protein regulating intracellular trafficking
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
EGFR phosphorylates EPS15
negativePrecedingEvent
[NegativePrecedingEvent:9865813] Futile Cycle: PTPN3 dephosphorylates EPS15
orthologousEvent
[Reaction:R-CEL-8867041] EGFR phosphorylates EPS15 - Caenorhabditis elegans
[Reaction:R-DME-8867041] EGFR phosphorylates EPS15 - Drosophila melanogaster
[Reaction:R-GGA-8867041] EGFR phosphorylates EPS15 - Gallus gallus
[Reaction:R-SSC-8867041] EGFR phosphorylates EPS15 - Sus scrofa
[Reaction:R-BTA-8867041] EGFR phosphorylates EPS15 - Bos taurus
[Reaction:R-CFA-8867041] EGFR phosphorylates EPS15 - Canis familiaris
[Reaction:R-RNO-8867041] EGFR phosphorylates EPS15 - Rattus norvegicus
[Reaction:R-MMU-8867041] EGFR phosphorylates EPS15 - Mus musculus
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-8867035] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane]
precedingEvent
[Reaction:R-HSA-8867044] EGFR binds EPS15, EPN1, EPS15L1 - Homo sapiens
releaseDate
2016年06月15日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8869706] Chen, Guang-Chao, 2016年05月06日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8867041
summation
[Summation:8867040] EPS15 is phosphorylated at Y849 by activated EGFR (Confaloni...
Referrals
(hasEvent)
[Pathway:R-HSA-182971] EGFR downregulation
(precedingEvent)
[Reaction:R-HSA-8867047] PTPN3 dephosphorylates EPS15
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