Reactome Pathway Database

Schema > Reaction > Entries

Sprouty sequesters CBL away from active EGFR Show undefined attributes

authored

[InstanceEdit:188408] Castagnoli, L, 2006年10月10日 13:09:34

category binding

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:183010] Jassal, B, 2006年07月21日 10:19:47

dbId 182990

displayName Sprouty sequesters CBL away from active EGFR

edited

[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011年08月25日

eventOf

[Pathway:R-HSA-182971] EGFR downregulation - Homo sapiens

input

isInDisease false

isInferred false

literatureReference

[LiteratureReference:183032] Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation

maxDepth 1

modified [InstanceEdit:10778922] Weiser, Joel, 2025年08月27日

name

Sprouty sequesters CBL away from active EGFR

orthologousEvent

output

[Complex:R-HSA-182931] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane]

precedingEvent

[Reaction:R-HSA-183072] EGFR non-clathrin mediated endocytosis - Homo sapiens

releaseDate 2008年03月12日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:212476] Heldin, CH, 2008年02月12日 09:44:02

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-182990

summation

[Summation:183026] Sprouty can constitutively interact with two SH3 domains of ...

updateTrackers

[UpdateTracker:9789269] Update Tracker - [Reaction:182990] Sprouty sequesters CBL away from active EGFR - v38:[modifyText]

Referrals

(updatedInstance)

[UpdateTracker:9789269] Update Tracker - [Reaction:182990] Sprouty sequesters CBL away from active EGFR - v38:[modifyText]

(hasEvent)

[Pathway:R-HSA-182971] EGFR downregulation

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