Reactome Pathway Database

Schema > Reaction > Entries

Sprouty sequesters CBL away from active EGFR Show undefined attributes

category binding

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:10424722] Weiser, Joel, 2025年08月27日

dbId 10440419

displayName Sprouty sequesters CBL away from active EGFR

eventOf

[Pathway:R-SSC-182971] EGFR downregulation - Sus scrofa

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-182990] Sprouty sequesters CBL away from active EGFR - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

Sprouty sequesters CBL away from active EGFR

output

[Complex:R-SSC-182931] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane]

precedingEvent

[Reaction:R-SSC-183072] EGFR non-clathrin mediated endocytosis - Sus scrofa

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:49633] Sus scrofa

stId R-SSC-182990

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-SSC-182971] EGFR downregulation

(inferredTo)

[Reaction:R-HSA-182990] Sprouty sequesters CBL away from active EGFR

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