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Schema
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Reaction
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Entries
Phosphorylation of CBL (EGFR:GRB2:CBL)
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authored
[InstanceEdit:188408] Castagnoli, L, 2006年10月10日 13:09:34
catalystActivity
[CatalystActivity:182979] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:183010] Jassal, B, 2006年07月21日 10:19:47
dbId
183058
displayName
Phosphorylation of CBL (EGFR:GRB2:CBL)
edited
[InstanceEdit:1529121] Orlic-Milacic, Marija, 2011年08月25日
eventOf
[Pathway:R-HSA-182971] EGFR downregulation - Homo sapiens
followingEvent
[Reaction:R-HSA-183036] Ubiquitination of stimulated EGFR (CBL:GRB2) - Homo sapiens
[Reaction:R-HSA-182994] Assembly of EGFR complex in clathrin-coated vesicles - Homo sapiens
input
2 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:183081] Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation
[LiteratureReference:183048] Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Phosphorylation of CBL (EGFR:GRB2:CBL)
orthologousEvent
[Reaction:R-XTR-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Xenopus tropicalis
[Reaction:R-DRE-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Danio rerio
[Reaction:R-CEL-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Caenorhabditis elegans
[Reaction:R-DME-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Drosophila melanogaster
[Reaction:R-GGA-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Gallus gallus
[Reaction:R-SSC-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Sus scrofa
[Reaction:R-BTA-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Bos taurus
[Reaction:R-CFA-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Canis familiaris
[Reaction:R-RNO-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Rattus norvegicus
[Reaction:R-MMU-183058] Phosphorylation of CBL (EGFR:GRB2:CBL) - Mus musculus
output
2 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-182948] EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane]
precedingEvent
[Reaction:R-HSA-183067] Localization of CBL:GRB2 to the membrane - Homo sapiens
[Reaction:R-HSA-183084] CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix - Homo sapiens
releaseDate
2008年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:212476] Heldin, CH, 2008年02月12日 09:44:02
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-183058
summation
[Summation:182991] EGF (and indeed FGF, PDGF and NGF) stimulation results in CB...
Referrals
(hasEvent)
[Pathway:R-HSA-182971] EGFR downregulation
(precedingEvent)
[Reaction:R-HSA-183036] Ubiquitination of stimulated EGFR (CBL:GRB2)
[Reaction:R-HSA-182994] Assembly of EGFR complex in clathrin-coated vesicles
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