Reactome Pathway Database

Schema > Pathway > Entries

EGFR downregulation Show undefined attributes

created [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

dbId 10946011

displayName EGFR downregulation

eventOf

[Pathway:R-CEL-177929] Signaling by EGFR - Caenorhabditis elegans

evidenceType [EvidenceType:9965817] inferred by electronic annotation

goBiologicalProcess [GO_BiologicalProcess:8094] negative regulation of epidermal growth factor receptor signaling pathway

hasDiagram false

hasEHLD false

hasEvent

inferredFrom

[Pathway:R-HSA-182971] EGFR downregulation - Homo sapiens

isInDisease false

isInferred true

maxDepth 2

name

EGFR downregulation

releaseDate 2025年09月18日

schemaClass Pathway

species

[Species:68320] Caenorhabditis elegans

stId R-CEL-182971

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-CEL-177929] Signaling by EGFR

(inferredTo)

[Pathway:R-HSA-182971] EGFR downregulation

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