Reactome Pathway Database

Schema > Reaction > Entries

EGFR dimerization Show undefined attributes

authored

[InstanceEdit:188408] Castagnoli, L, 2006年10月10日 13:09:34

category binding

compartment

created [InstanceEdit:177921] Jassal, Bijay, 2006年04月11日

dbId 177922

displayName EGFR dimerization

edited

[InstanceEdit:9851454] Orlic-Milacic, Marija, 2023年10月25日

eventOf

[Pathway:R-HSA-177929] Signaling by EGFR - Homo sapiens

followingEvent

[Reaction:R-HSA-1225978] Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers - Homo sapiens
[Reaction:R-HSA-177934] EGFR autophosphorylation - Homo sapiens
[Reaction:R-HSA-177937] Phosphorylation of EGFR by SRC kinase - Homo sapiens

input

2 × [Complex:R-HSA-9624419] EGFR:EGF-like ligands [plasma membrane]

isInDisease false

isInferred false

literatureReference

[LiteratureReference:188642] Activation of epidermal growth factor receptor by epidermal growth factor

maxDepth 1

modified [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

name

EGFR dimerization

orthologousEvent

output

[Complex:R-HSA-9624420] EGF-like ligands:EGFR dimer [plasma membrane]

precedingEvent

previousReviewStatus [ReviewStatus:9821384] two stars

regulatedBy

[PositiveRegulation:9851405] Positive regulation by 'EGFR:AAMP [plasma membrane]'

regulationReference

[RegulationReference:9851403] Positive regulation by 'EGFR:AAMP [plasma membrane]' Angio-associated migratory cell protein interacts with epidermal growth factor receptor and enhances proliferation and drug resistance in human non-small cell lung cancer cells

releaseDate 2007年02月20日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-177922

summation

[Summation:188442] EGF and other growth factors induce oligomerization of their...

updateTrackers

Referrals

(updatedInstance)

(precedingEvent)

(normalReaction)

[Reaction:R-HSA-1220613] EGF-induced dimerization of ligand-responsive EGFR mutants

(hasEvent)

[Pathway:R-HSA-177929] Signaling by EGFR

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