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Schema
>
Reaction
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Entries
EGF-induced dimerization of ligand-responsive EGFR mutants
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authored
[InstanceEdit:1972359] Orlic-Milacic, M, 2011年11月04日
category
binding
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created
[InstanceEdit:1220609] Orlic-Milacic, Marija, 2011年02月22日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
1220613
disease
[Disease:1500689] cancer
displayName
EGF-induced dimerization of ligand-responsive EGFR mutants
edited
[InstanceEdit:1972360] D'Eustachio, P, 2011年11月07日
[InstanceEdit:1972361] Matthews, L, 2011年11月07日
[InstanceEdit:1990853] Wu, G, 2011年11月07日
entityFunctionalStatus
[EntityFunctionalStatus:5637729] gain_of_function of EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane]
eventOf
[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - Homo sapiens
followingEvent
[Reaction:R-HSA-1220610] Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants - Homo sapiens
[Reaction:R-HSA-1169421] Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers - Homo sapiens
input
2 ×
[DefinedSet:R-HSA-1220578] EGF:Ligand-responsive EGFR mutants:HSP90:CDC37 [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1181011] An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
[LiteratureReference:1181018] Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants
[LiteratureReference:1169414] Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
[LiteratureReference:1181025] The juxtamembrane region of the EGF receptor functions as an activation domain
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
EGF-induced dimerization of ligand-responsive EGFR mutants
normalReaction
[Reaction:R-HSA-177922] EGFR dimerization
output
[Complex:R-HSA-1500847] EGF:Ligand-responsive EGFR mutants dimer [plasma membrane]
precedingEvent
[Reaction:R-HSA-1220612] Binding of EGF to ligand-responsive EGFR mutants - Homo sapiens
releaseDate
2011年12月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1990843] Greulich, H, 2011年11月15日
[InstanceEdit:1990844] Savas, S, 2011年11月15日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1220613
summation
[Summation:1247597] Although ligand-responsive EGFR mutants dimerize spontaneous...
Referrals
(hasEvent)
[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
(precedingEvent)
[Reaction:R-HSA-1220610] Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants
[Reaction:R-HSA-1169421] Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers
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