Reactome | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

authored

[InstanceEdit:1972359] Orlic-Milacic, M, 2011年11月04日

compartment

created [InstanceEdit:1236383] Orlic-Milacic, Marija, 2011年03月25日

crossReference

dbId 1236382

disease

[Disease:1500689] cancer

displayName Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

edited

eventOf

[Pathway:R-HSA-5637815] Signaling by Ligand-Responsive EGFR Variants in Cancer - Homo sapiens

hasDiagram false

hasEHLD false

hasEvent

[Reaction:R-HSA-1218833] Binding of ligand-responsive EGFR mutants to chaperoning proteins HSP90 and CDC37 - Homo sapiens
[Reaction:R-HSA-1220612] Binding of EGF to ligand-responsive EGFR mutants - Homo sapiens
[Reaction:R-HSA-1220613] EGF-induced dimerization of ligand-responsive EGFR mutants - Homo sapiens
[Reaction:R-HSA-1220614] Spontaneous dimerization of ligand-responsive EGFR mutants - Homo sapiens
[Reaction:R-HSA-1169421] Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers - Homo sapiens
[Reaction:R-HSA-1225950] Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants - Homo sapiens
[Reaction:R-HSA-1225951] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) - Homo sapiens
[Reaction:R-HSA-1225947] Binding of SHC1 to p-6Y-EGFR mutants - Homo sapiens
[Reaction:R-HSA-1225952] Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants - Homo sapiens
[Reaction:R-HSA-1225961] Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex - Homo sapiens
[Reaction:R-HSA-1225957] SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) - Homo sapiens
[Reaction:R-HSA-1226016] Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants - Homo sapiens
[Reaction:R-HSA-1226012] Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants - Homo sapiens
[Reaction:R-HSA-1226014] Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants - Homo sapiens
[Reaction:R-HSA-1247841] PLCG1 binds to ligand-responsive p-6Y-EGFR mutants - Homo sapiens
[Reaction:R-HSA-1247844] Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants - Homo sapiens
[Reaction:R-HSA-1247842] Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants - Homo sapiens
[Reaction:R-HSA-1225949] Binding of CBL to ligand-responsive p-6Y-EGFR mutants - Homo sapiens
[Reaction:R-HSA-1225960] Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants - Homo sapiens
[FailedReaction:R-HSA-1225956] Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL - Homo sapiens
[Reaction:R-HSA-1218824] HSP90 is inactivated by binding to benzaquinoid ansamycins - Homo sapiens
[Reaction:R-HSA-1220610] Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants - Homo sapiens
[Reaction:R-HSA-1220611] Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors - Homo sapiens

isInDisease true

isInferred false

lastUpdatedDate 2023年06月07日

maxDepth 2

modified [InstanceEdit:9847082] Weiser, Joel, 2023年10月12日

name

Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

releaseDate 2011年12月06日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Pathway

species

[Species:48887] Homo sapiens

stId R-HSA-1236382

summation

[Summation:1181246] Signaling by EGFR is frequently activated in cancer through ...

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