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Schema
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Reaction
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Entries
Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants
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authored
[InstanceEdit:1972359] Orlic-Milacic, M, 2011年11月04日
catalystActivity
[CatalystActivity:1225927] protein tyrosine kinase activity of Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created
[InstanceEdit:1225955] Orlic-Milacic, Marija, 2011年03月03日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
1225952
disease
[Disease:1500689] cancer
displayName
Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants
edited
[InstanceEdit:1972360] D'Eustachio, P, 2011年11月07日
[InstanceEdit:1972361] Matthews, L, 2011年11月07日
[InstanceEdit:1990853] Wu, G, 2011年11月07日
entityFunctionalStatus
[EntityFunctionalStatus:5637731] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane]
eventOf
[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - Homo sapiens
followingEvent
[Reaction:R-HSA-1225961] Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex - Homo sapiens
input
2 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-1225858] Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1181018] Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants
normalReaction
[Reaction:R-HSA-177933] SHC1 phosphorylation by phosphorylated EGFR
output
2 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-1225854] Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-1225947] Binding of SHC1 to p-6Y-EGFR mutants - Homo sapiens
releaseDate
2011年12月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1990843] Greulich, H, 2011年11月15日
[InstanceEdit:1990844] Savas, S, 2011年11月15日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1225952
summation
[Summation:1225954] Constitutive phosphorylation of SHC1 was directly demonstrat...
Referrals
(precedingEvent)
[Reaction:R-HSA-1225961] Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex
(hasEvent)
[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
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