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Reaction
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Entries
Binding of SHC1 to p-6Y-EGFR mutants
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authored
[InstanceEdit:1972359] Orlic-Milacic, M, 2011年11月04日
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:1225955] Orlic-Milacic, Marija, 2011年03月03日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
1225947
disease
[Disease:1500689] cancer
displayName
Binding of SHC1 to p-6Y-EGFR mutants
edited
[InstanceEdit:1972360] D'Eustachio, P, 2011年11月07日
[InstanceEdit:1972361] Matthews, L, 2011年11月07日
[InstanceEdit:1990853] Wu, G, 2011年11月07日
entityFunctionalStatus
[EntityFunctionalStatus:5637728] gain_of_function of Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane]
eventOf
[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - Homo sapiens
followingEvent
[Reaction:R-HSA-5637796] Phosphorylation of SHC1 by p-5Y-EGFRvIII - Homo sapiens
[Reaction:R-HSA-1225952] Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants - Homo sapiens
input
[DefinedSet:R-HSA-1181062] Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-74680] SHC1 [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1225829] Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
[LiteratureReference:1181018] Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants
[LiteratureReference:2008120] EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes
[LiteratureReference:1248637] Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII
[LiteratureReference:2008136] Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition
[LiteratureReference:1248643] Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Binding of SHC1 to p-6Y-EGFR mutants
normalReaction
[Reaction:R-HSA-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex
output
[Complex:R-HSA-1225858] Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-1169421] Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers - Homo sapiens
[Reaction:R-HSA-1248655] Trans-autophosphorylation of EGFRvIII mutant dimers - Homo sapiens
releaseDate
2011年12月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1990843] Greulich, H, 2011年11月15日
[InstanceEdit:1990844] Savas, S, 2011年11月15日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1225947
summation
[Summation:1247600] SHC1 (Src homology 2 domain-containing transforming protein)...
updateTrackers
[UpdateTracker:9835694] Update Tracker - [Reaction:1225947] Binding of SHC1 to p-6Y-EGFR mutants - v85:[modifyText]
[UpdateTracker:9785574] Update Tracker - [Reaction:1225947] Binding of SHC1 to p-6Y-EGFR mutants - v51:[add_removeInput]
Referrals
(updatedInstance)
[UpdateTracker:9835694] Update Tracker - [Reaction:1225947] Binding of SHC1 to p-6Y-EGFR mutants - v85:[modifyText]
[UpdateTracker:9785574] Update Tracker - [Reaction:1225947] Binding of SHC1 to p-6Y-EGFR mutants - v51:[add_removeInput]
(precedingEvent)
[Reaction:R-HSA-5637796] Phosphorylation of SHC1 by p-5Y-EGFRvIII
[Reaction:R-HSA-1225952] Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants
(hasEvent)
[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
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