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Reaction
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Entries
Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants
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authored
[InstanceEdit:1972359] Orlic-Milacic, M, 2011年11月04日
catalystActivity
[CatalystActivity:1247843] protein tyrosine kinase activity of Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:1247840] Orlic-Milacic, Marija, 2011年04月07日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
1247844
disease
[Disease:1500689] cancer
displayName
Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants
edited
[InstanceEdit:1972360] D'Eustachio, P, 2011年11月07日
[InstanceEdit:1972361] Matthews, L, 2011年11月07日
[InstanceEdit:1990853] Wu, G, 2011年11月07日
entityFunctionalStatus
[EntityFunctionalStatus:5637726] gain_of_function of Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane]
eventOf
[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants - Homo sapiens
followingEvent
[Reaction:R-HSA-1247842] Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants - Homo sapiens
input
4 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-1247845] Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:212708] Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro
[LiteratureReference:212704] Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants
normalReaction
[Reaction:R-HSA-212710] EGFR activates PLC-gamma1 by phosphorylation
output
4 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-1247846] Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-1247841] PLCG1 binds to ligand-responsive p-6Y-EGFR mutants - Homo sapiens
releaseDate
2011年12月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1990843] Greulich, H, 2011年11月15日
[InstanceEdit:1990844] Savas, S, 2011年11月15日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1247844
summation
[Summation:1247837] Once recruited, PLC-gamma 1 is assumed to be phosphorylated ...
Referrals
(hasEvent)
[Pathway:R-HSA-1236382] Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
(precedingEvent)
[Reaction:R-HSA-1247842] Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants
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