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Schema
>
Reaction
>
Entries
EGFR activates PLC-gamma1 by phosphorylation
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authored
[InstanceEdit:212714] Jassal, Bijay, 2008年02月13日
catalystActivity
[CatalystActivity:212705] protein tyrosine kinase activity of EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created
[InstanceEdit:212707] Jassal, Bijay, 2008年02月13日
dbId
212710
displayName
EGFR activates PLC-gamma1 by phosphorylation
eventOf
[Pathway:R-HSA-212718] EGFR interacts with phospholipase C-gamma - Homo sapiens
followingEvent
[Reaction:R-HSA-212713] Active PLC-gamma1 dissociates from EGFR - Homo sapiens
input
4 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:212708] Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro
[LiteratureReference:212704] Identification of two epidermal growth factor-sensitive tyrosine phosphorylation sites of phospholipase C-gamma in intact HSC-1 cells
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
EGFR activates PLC-gamma1 by phosphorylation
orthologousEvent
[Reaction:R-DME-212710] EGFR activates PLC-gamma1 by phosphorylation - Drosophila melanogaster
[Reaction:R-GGA-212710] EGFR activates PLC-gamma1 by phosphorylation - Gallus gallus
[Reaction:R-XTR-212710] EGFR activates PLC-gamma1 by phosphorylation - Xenopus tropicalis
[Reaction:R-DRE-212710] EGFR activates PLC-gamma1 by phosphorylation - Danio rerio
[Reaction:R-SSC-212710] EGFR activates PLC-gamma1 by phosphorylation - Sus scrofa
[Reaction:R-BTA-212710] EGFR activates PLC-gamma1 by phosphorylation - Bos taurus
[Reaction:R-CFA-212710] EGFR activates PLC-gamma1 by phosphorylation - Canis familiaris
[Reaction:R-RNO-212710] EGFR activates PLC-gamma1 by phosphorylation - Rattus norvegicus
[Reaction:R-MMU-212710] EGFR activates PLC-gamma1 by phosphorylation - Mus musculus
output
4 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-212703] EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Homo sapiens
releaseDate
2008年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:212476] Heldin, CH, 2008年02月12日 09:44:02
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-212710
summation
[Summation:213064] EGFR phosphorylates PLC-gamma1, thus activating it.
Referrals
(normalReaction)
[Reaction:R-HSA-5637795] Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant
[Reaction:R-HSA-1247844] Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants
(hasEvent)
[Pathway:R-HSA-212718] EGFR interacts with phospholipase C-gamma
(precedingEvent)
[Reaction:R-HSA-212713] Active PLC-gamma1 dissociates from EGFR
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