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Schema
>
Reaction
>
Entries
Phospholipase C-gamma1 binds to the activated EGF receptor
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authored
[InstanceEdit:212714] Jassal, Bijay, 2008年02月13日
category
binding
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
[Compartment:984] extracellular region
created
[InstanceEdit:212707] Jassal, Bijay, 2008年02月13日
dbId
212706
displayName
Phospholipase C-gamma1 binds to the activated EGF receptor
eventOf
[Pathway:R-HSA-212718] EGFR interacts with phospholipase C-gamma - Homo sapiens
followingEvent
[Reaction:R-HSA-212710] EGFR activates PLC-gamma1 by phosphorylation - Homo sapiens
input
[Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-202320] PLCG1 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:212708] Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro
[LiteratureReference:212712] Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor
maxDepth
1
modified
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
name
Phospholipase C-gamma1 binds to the activated EGF receptor
negativePrecedingEvent
[NegativePrecedingEvent:9865810] Futile Cycle: Active PLC-gamma1 dissociates from EGFR
orthologousEvent
[Reaction:R-DME-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Drosophila melanogaster
[Reaction:R-GGA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Gallus gallus
[Reaction:R-XTR-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Xenopus tropicalis
[Reaction:R-DRE-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Danio rerio
[Reaction:R-SSC-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Sus scrofa
[Reaction:R-BTA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Bos taurus
[Reaction:R-CFA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Canis familiaris
[Reaction:R-RNO-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Rattus norvegicus
[Reaction:R-MMU-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Mus musculus
output
[Complex:R-HSA-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-177937] Phosphorylation of EGFR by SRC kinase - Homo sapiens
[Reaction:R-HSA-177934] EGFR autophosphorylation - Homo sapiens
releaseDate
2008年03月12日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:212476] Heldin, CH, 2008年02月12日 09:44:02
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-212706
summation
[Summation:213065] Inactive phospholipase C-gamma1 (PLCG1) binds to activated e...
updateTrackers
[UpdateTracker:9778885] Update Tracker - [Reaction:212706] Phospholipase C-gamma1 binds to the activated EGF receptor - v67:[add_removeInput]
[UpdateTracker:9789081] Update Tracker - [Reaction:212706] Phospholipase C-gamma1 binds to the activated EGF receptor - v38:[modifyText]
[UpdateTracker:9788877] Update Tracker - [Reaction:212706] Phospholipase C-gamma1 binds to the activated EGF receptor - v40:[add_removeInput]
Referrals
(updatedInstance)
[UpdateTracker:9778885] Update Tracker - [Reaction:212706] Phospholipase C-gamma1 binds to the activated EGF receptor - v67:[add_removeInput]
[UpdateTracker:9789081] Update Tracker - [Reaction:212706] Phospholipase C-gamma1 binds to the activated EGF receptor - v38:[modifyText]
[UpdateTracker:9788877] Update Tracker - [Reaction:212706] Phospholipase C-gamma1 binds to the activated EGF receptor - v40:[add_removeInput]
(normalReaction)
[Reaction:R-HSA-5637792] PLC-gamma 1 binds to p-EGFRvIII mutant
[Reaction:R-HSA-1247841] PLCG1 binds to ligand-responsive p-6Y-EGFR mutants
(hasEvent)
[Pathway:R-HSA-212718] EGFR interacts with phospholipase C-gamma
(precedingEvent)
[Reaction:R-HSA-212710] EGFR activates PLC-gamma1 by phosphorylation
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