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Go!
Schema
>
Complex
>
Entries
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
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compartment
[Compartment:876] plasma membrane
componentOf
[Complex:R-HSA-9625464] EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] - Homo sapiens
[Complex:R-HSA-182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] - Homo sapiens
[Complex:R-HSA-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - Homo sapiens
consumedByEvent
[Reaction:R-HSA-9625482] PTK2 binds activated EGFR - Homo sapiens
[Reaction:R-HSA-183067] Localization of CBL:GRB2 to the membrane - Homo sapiens
[Reaction:R-HSA-183055] Binding of CBL to EGFR - Homo sapiens
[Reaction:R-HSA-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Homo sapiens
[Reaction:R-HSA-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - Homo sapiens
[Reaction:R-HSA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Homo sapiens
[Reaction:R-HSA-177941] GRB2:GAB1 binds to phosphorylated EGFR - Homo sapiens
created
[InstanceEdit:9624424] Rothfels, Karen, 2018年10月11日
dbId
9624425
displayName
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
hasComponent
2 ×
[DefinedSet:R-HSA-9624194] EGF-like ligands [extracellular region]
2 ×
[EntityWithAccessionedSequence:R-HSA-179803] p-6Y-EGFR [plasma membrane]
inDisease
false
includedLocation
[Compartment:984] extracellular region
inferredTo
[Complex:R-MMU-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] - Mus musculus
[Complex:R-RNO-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] - Rattus norvegicus
[Complex:R-CFA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] - Canis familiaris
[Complex:R-BTA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] - Bos taurus
[Complex:R-SSC-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] - Sus scrofa
[Complex:R-DRE-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] - Danio rerio
[Complex:R-XTR-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] - Xenopus tropicalis
[Complex:R-GGA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] - Gallus gallus
[Complex:R-DME-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] - Drosophila melanogaster
[Complex:R-CEL-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] - Caenorhabditis elegans
isChimeric
false
maxDepth
3
name
EGF-like ligands:p-6Y EGFR dimer
producedByEvent
[Reaction:R-HSA-212713] Active PLC-gamma1 dissociates from EGFR - Homo sapiens
[Reaction:R-HSA-177934] EGFR autophosphorylation - Homo sapiens
[Reaction:R-HSA-177937] Phosphorylation of EGFR by SRC kinase - Homo sapiens
schemaClass
Complex
species
[Species:48887] Homo sapiens
stId
R-HSA-9624425
Referrals
(normalEntity)
[EntityFunctionalStatus:5637711] loss_of_function of p-5Y-EGFRvIII mutant dimer [plasma membrane]
[EntityFunctionalStatus:5638131] gain_of_function of p-5Y-EGFRvIII mutant dimer [plasma membrane]
[EntityFunctionalStatus:5637728] gain_of_function of Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane]
(input)
[Reaction:R-HSA-183067] Localization of CBL:GRB2 to the membrane
[Reaction:R-HSA-183055] Binding of CBL to EGFR
[Reaction:R-HSA-9625482] PTK2 binds activated EGFR
[Reaction:R-HSA-177943] GRB2:SOS1 complex binds to EGF:EGFR complex
[Reaction:R-HSA-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex
[Reaction:R-HSA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor
[Reaction:R-HSA-177941] GRB2:GAB1 binds to phosphorylated EGFR
(hasComponent)
[Complex:R-HSA-182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane]
[Complex:R-HSA-182960] EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane]
[Complex:R-HSA-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane]
[Complex:R-HSA-9625464] EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane]
[Complex:R-HSA-9625453] EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane]
[Complex:R-HSA-9624427] EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane]
[Complex:R-HSA-179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
[Complex:R-HSA-180337] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane]
[Complex:R-HSA-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]
[Complex:R-HSA-212703] EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane]
[Complex:R-HSA-180348] EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane]
[Complex:R-HSA-180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane]
(output)
[Reaction:R-HSA-212713] Active PLC-gamma1 dissociates from EGFR
[Reaction:R-HSA-177934] EGFR autophosphorylation
[Reaction:R-HSA-177937] Phosphorylation of EGFR by SRC kinase
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