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Schema
>
Complex
>
Entries
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
Show undefined attributes
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compartment
[Compartment:876] plasma membrane
componentOf
[Complex:R-DME-182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] - Drosophila melanogaster
[Complex:R-DME-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] - Drosophila melanogaster
consumedByEvent
[Reaction:R-DME-183067] Localization of CBL:GRB2 to the membrane - Drosophila melanogaster
[Reaction:R-DME-183055] Binding of CBL to EGFR - Drosophila melanogaster
[Reaction:R-DME-177943] GRB2:SOS1 complex binds to EGF:EGFR complex - Drosophila melanogaster
[Reaction:R-DME-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - Drosophila melanogaster
[Reaction:R-DME-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Drosophila melanogaster
[Reaction:R-DME-177941] GRB2:GAB1 binds to phosphorylated EGFR - Drosophila melanogaster
created
[InstanceEdit:10778922] Weiser, Joel, 2025年08月27日
dbId
10790400
displayName
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
hasComponent
2 ×
[DefinedSet:R-DME-179863-3] Homologues of EGF [extracellular region]
2 ×
[EntityWithAccessionedSequence:R-DME-179803] phospho-p-6Y-EGFR [plasma membrane]
inDisease
false
inferredFrom
[Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane] - Homo sapiens
maxDepth
3
name
EGF-like ligands:p-6Y EGFR dimer
producedByEvent
[Reaction:R-DME-212713] Active PLC-gamma1 dissociates from EGFR - Drosophila melanogaster
[Reaction:R-DME-177934] EGFR autophosphorylation - Drosophila melanogaster
[Reaction:R-DME-177937] Phosphorylation of EGFR by SRC kinase - Drosophila melanogaster
schemaClass
Complex
species
[Species:56210] Drosophila melanogaster
stId
R-DME-9624425
summation
[Summation:9965818] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Referrals
(input)
[Reaction:R-DME-183067] Localization of CBL:GRB2 to the membrane
[Reaction:R-DME-183055] Binding of CBL to EGFR
[Reaction:R-DME-177943] GRB2:SOS1 complex binds to EGF:EGFR complex
[Reaction:R-DME-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex
[Reaction:R-DME-212706] Phospholipase C-gamma1 binds to the activated EGF receptor
[Reaction:R-DME-177941] GRB2:GAB1 binds to phosphorylated EGFR
(hasComponent)
[Complex:R-DME-182928] EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane]
[Complex:R-DME-182960] EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane]
[Complex:R-DME-180503] EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane]
[Complex:R-DME-9624427] EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane]
[Complex:R-DME-179820] EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
[Complex:R-DME-180337] EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane]
[Complex:R-DME-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]
[Complex:R-DME-212703] EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane]
[Complex:R-DME-180348] EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane]
[Complex:R-DME-180286] EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane]
(output)
[Reaction:R-DME-212713] Active PLC-gamma1 dissociates from EGFR
[Reaction:R-DME-177934] EGFR autophosphorylation
[Reaction:R-DME-177937] Phosphorylation of EGFR by SRC kinase
(inferredTo)
[Complex:R-HSA-9624425] EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
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