Reactome Pathway Database

Schema > Reaction > Entries

SHC1 binds to the phosphorylated EGF receptor:ligand complex Show undefined attributes

category binding

compartment

created [InstanceEdit:10778922] Weiser, Joel, 2025年08月27日

dbId 10790423

displayName SHC1 binds to the phosphorylated EGF receptor:ligand complex

eventOf

[Pathway:R-DME-180336] SHC1 events in EGFR signaling - Drosophila melanogaster

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-DME-177933] SHC1 phosphorylation by phosphorylated EGFR - Drosophila melanogaster

inferredFrom

[Reaction:R-HSA-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

SHC1 binds to the phosphorylated EGF receptor:ligand complex

output

[Complex:R-DME-9624427] EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane]

precedingEvent

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:56210] Drosophila melanogaster

stId R-DME-177925

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-DME-180336] SHC1 events in EGFR signaling

(precedingEvent)

[Reaction:R-DME-177933] SHC1 phosphorylation by phosphorylated EGFR

(inferredTo)

[Reaction:R-HSA-177925] SHC1 binds to the phosphorylated EGF receptor:ligand complex

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