Reactome Pathway Database

Schema > Reaction > Entries

Phospholipase C-gamma1 binds to the activated EGF receptor Show undefined attributes

category binding

compartment

created [InstanceEdit:10778922] Weiser, Joel, 2025年08月27日

dbId 10795682

displayName Phospholipase C-gamma1 binds to the activated EGF receptor

eventOf

[Pathway:R-DME-212718] EGFR interacts with phospholipase C-gamma - Drosophila melanogaster

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-DME-212710] EGFR activates PLC-gamma1 by phosphorylation - Drosophila melanogaster

inferredFrom

[Reaction:R-HSA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

Phospholipase C-gamma1 binds to the activated EGF receptor

output

[Complex:R-DME-212717] EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane]

precedingEvent

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:56210] Drosophila melanogaster

stId R-DME-212706

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-DME-212718] EGFR interacts with phospholipase C-gamma

(precedingEvent)

[Reaction:R-DME-212710] EGFR activates PLC-gamma1 by phosphorylation

(inferredTo)

[Reaction:R-HSA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor

© 2025 Reactome

Cite Us!