Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
PLC-gamma 1 binds to p-EGFRvIII mutant
Show undefined attributes
Go to Details
authored
[InstanceEdit:1972359] Orlic-Milacic, M, 2011年11月04日
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:5637793] Orlic-Milacic, Marija, 2014年11月12日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
5637792
disease
[Disease:1500689] cancer
displayName
PLC-gamma 1 binds to p-EGFRvIII mutant
edited
[InstanceEdit:1972360] D'Eustachio, P, 2011年11月07日
[InstanceEdit:1972361] Matthews, L, 2011年11月07日
[InstanceEdit:1990853] Wu, G, 2011年11月07日
entityFunctionalStatus
[EntityFunctionalStatus:5638131] gain_of_function of p-5Y-EGFRvIII mutant dimer [plasma membrane]
eventOf
[Pathway:R-HSA-5637810] Constitutive Signaling by EGFRvIII - Homo sapiens
followingEvent
[Reaction:R-HSA-5637795] Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant - Homo sapiens
input
[Complex:R-HSA-1248654] p-5Y-EGFRvIII mutant dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-167682] PLCG1 [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:2008120] EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
PLC-gamma 1 binds to p-EGFRvIII mutant
normalReaction
[Reaction:R-HSA-212706] Phospholipase C-gamma1 binds to the activated EGF receptor
output
[Complex:R-HSA-5637698] p-5Y-EGFRvIII:PLCG1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-1248655] Trans-autophosphorylation of EGFRvIII mutant dimers - Homo sapiens
releaseDate
2011年12月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1990843] Greulich, H, 2011年11月15日
[InstanceEdit:1990844] Savas, S, 2011年11月15日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5637792
summation
[Summation:5637771] Tyrosine residue Y992 (corresponding to Y1016 when counting ...
Referrals
(hasEvent)
[Pathway:R-HSA-5637810] Constitutive Signaling by EGFRvIII
(precedingEvent)
[Reaction:R-HSA-5637795] Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル