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Schema
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Reaction
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Entries
Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers
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authored
[InstanceEdit:1972359] Orlic-Milacic, M, 2011年11月04日
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:1225980] Orlic-Milacic, Marija, 2011年03月03日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
1225978
disease
[Disease:1500689] cancer
displayName
Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers
edited
[InstanceEdit:1972360] D'Eustachio, P, 2011年11月07日
[InstanceEdit:1972361] Matthews, L, 2011年11月07日
[InstanceEdit:1990853] Wu, G, 2011年11月07日
eventOf
[Pathway:R-HSA-5638303] Inhibition of Signaling by Overexpressed EGFR - Homo sapiens
input
2 ×
[DefinedSet:R-ALL-1216522] Covalent EGFR tyrosine kinase inhibitors [cytosol]
[Complex:R-HSA-9624420] EGF-like ligands:EGFR dimer [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1225967] Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
maxDepth
1
modified
[InstanceEdit:9865824] Orlic-Milacic, Marija, 2024年03月19日
name
Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers
output
[Complex:R-HSA-1225979] EGF-like ligands:EGFR Dimer:Covalent EGFR TKIs [plasma membrane]
precedingEvent
[Reaction:R-HSA-177922] EGFR dimerization - Homo sapiens
releaseDate
2011年12月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1990843] Greulich, H, 2011年11月15日
[InstanceEdit:1990844] Savas, S, 2011年11月15日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-1225978
summation
[Summation:1247599] Covalent (irreversible) TKIs, pelitinib, WZ4002, HKI-272, ca...
updateTrackers
[UpdateTracker:9778950] Update Tracker - [Reaction:1225978] Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers - v67:[add_removeInput]
Referrals
(updatedInstance)
[UpdateTracker:9778950] Update Tracker - [Reaction:1225978] Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers - v67:[add_removeInput]
(hasEvent)
[Pathway:R-HSA-5638303] Inhibition of Signaling by Overexpressed EGFR
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