Reactome Pathway Database

Schema > Reaction > Entries

EGFR dimerization Show undefined attributes

category binding

compartment

created [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

dbId 10878131

displayName EGFR dimerization

eventOf

[Pathway:R-CEL-177929] Signaling by EGFR - Caenorhabditis elegans

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

inferredFrom

[Reaction:R-HSA-177922] EGFR dimerization - Homo sapiens

input

2 × [Complex:R-CEL-9624419] EGFR:EGF-like ligands [plasma membrane]

isInDisease false

isInferred true

maxDepth 1

name

EGFR dimerization

output

[Complex:R-CEL-9624420] EGF-like ligands:EGFR dimer [plasma membrane]

precedingEvent

regulatedBy

[PositiveRegulation:10878132] Positive regulation by 'EGFR:AAMP [plasma membrane]'

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:68320] Caenorhabditis elegans

stId R-CEL-177922

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-CEL-177929] Signaling by EGFR

(precedingEvent)

(inferredTo)

[Reaction:R-HSA-177922] EGFR dimerization

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