Reactome | Signaling by ERBB4

authored

compartment

created [InstanceEdit:1236397] Orlic-Milacic, Marija, 2011年03月25日

crossReference

dbId 1236394

displayName Signaling by ERBB4

doi 10.3180/R-HSA-1236394.3

edited

eventOf

[Pathway:R-HSA-9006934] Signaling by Receptor Tyrosine Kinases - Homo sapiens

figure

[Figure:2291888] /figures/Pathway_Illustrations/ERBB4_72_oicr.png

hasDiagram true

hasEHLD false

hasEvent

isInDisease false

isInferred false

lastUpdatedDate 2019年06月12日

literatureReference

[LiteratureReference:1254429] Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation
[LiteratureReference:1254427] Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2
[LiteratureReference:1247834] ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms
[LiteratureReference:1254428] Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases
[LiteratureReference:1254439] Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4
[LiteratureReference:1254437] Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer
[LiteratureReference:1250222] Ligand discrimination in signaling through an ErbB4 receptor homodimer
[LiteratureReference:1250122] Neuregulin-1 only induces trans-phosphorylation between ErbB receptor heterodimer partners
[LiteratureReference:1250306] HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers
[LiteratureReference:1250297] System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties
[LiteratureReference:1248688] Identification of autophosphorylation sites of HER2/neu
[LiteratureReference:1973954] The cellular response to neuregulins is governed by complex interactions of the erbB receptor family
[LiteratureReference:1248733] Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions
[LiteratureReference:1250369] A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis
[LiteratureReference:1252006] Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4
[LiteratureReference:1251998] Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment
[LiteratureReference:1252005] gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
[LiteratureReference:1253316] Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain
[LiteratureReference:1254286] The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone
[LiteratureReference:1254297] Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation
[LiteratureReference:1254407] Coregulation of estrogen receptor by ERBB4/HER4 establishes a growth-promoting autocrine signal in breast tumor cells
[LiteratureReference:1254249] WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus
[LiteratureReference:1254250] Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level
[LiteratureReference:1253338] WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function
[LiteratureReference:1254404] The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells
[LiteratureReference:1253272] The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation
[LiteratureReference:1253295] The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation
[LiteratureReference:1973946] Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells
[LiteratureReference:2029517] Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1
[LiteratureReference:9612773] ErbB4 regulation of a thalamic reticular nucleus circuit for sensory selection
[LiteratureReference:9612772] Gene expression profiling of ErbB receptor and ligand-dependent transcription
[LiteratureReference:9612796] Erbb4 deletion from fast-spiking interneurons causes schizophrenia-like phenotypes
[LiteratureReference:9612797] Neuregulin 1-ErbB4 signaling in the bed nucleus of the stria terminalis regulates anxiety-like behavior
[LiteratureReference:9612798] Neuregulin 1 protects against ischemic brain injury via ErbB4 receptors by increasing GABAergic transmission
[LiteratureReference:9612815] Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake
[LiteratureReference:9612835] Neuregulin 1/ErbB4 enhances synchronized oscillations of prefrontal cortex neurons via inhibitory synapses
[LiteratureReference:9612834] Maintenance of GABAergic activity by neuregulin 1-ErbB4 in amygdala for fear memory
[LiteratureReference:9612570] ErbB4 reduces synaptic GABAA currents independent of its receptor tyrosine kinase activity
[LiteratureReference:9612826] Neuregulin-1/ErbB4 Signaling Regulates Visual Cortical Plasticity
[LiteratureReference:9612831] Neuregulin-1 protects against neurotoxicities induced by Swedish amyloid precursor protein via the ErbB4 receptor
[LiteratureReference:9638212] Secretase-dependent tyrosine phosphorylation of Mdm2 by the ErbB-4 intracellular domain fragment
[LiteratureReference:9638209] Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways
[LiteratureReference:9638198] ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation
[LiteratureReference:9638195] Interaction with ErbB4 promotes hypoxia-inducible factor-1? signaling
[LiteratureReference:9638207] Constitutively active ErbB4 and ErbB2 mutants exhibit distinct biological activities
[LiteratureReference:9638213] Phosphotyrosine interactome of the ErbB-receptor kinase family
[LiteratureReference:9612239] Convergent and divergent cellular responses by ErbB4 isoforms in mammary epithelial cells

maxDepth 3

modified [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

name

Signaling by ERBB4

orthologousEvent

releaseDate 2011年12月06日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

revised

schemaClass Pathway

species

[Species:48887] Homo sapiens

stId R-HSA-1236394

summation

[Summation:1257607] ERBB4, also known as HER4, belongs to the ERBB family of rec...

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