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Signaling by RAF1 mutants Show undefined attributes

authored

[InstanceEdit:9664643] Rothfels, Karen, 2019年10月25日

created [InstanceEdit:9656222] Rothfels, Karen, 2019年07月27日

crossReference

dbId 9656223

disease

displayName Signaling by RAF1 mutants

edited

[InstanceEdit:9690121] Rothfels, Karen, 2020年05月26日

eventOf

[Pathway:R-HSA-6802957] Oncogenic MAPK signaling - Homo sapiens

hasDiagram true

hasEHLD false

hasEvent

[FailedReaction:R-HSA-9656207] CR2 RAF1 mutants don't bind YWHAB - Homo sapiens
[Reaction:R-HSA-9656213] RAF1 mutants show enhanced heterodimerization with BRAF - Homo sapiens
[Reaction:R-HSA-9656212] Phosphorylation of RAF1 mutants - Homo sapiens
[Reaction:R-HSA-9656211] MAP2Ks and MAPKs bind to the activated mutant RAF1 complex - Homo sapiens
[Reaction:R-HSA-9656215] RAF1 mutant complexes phosphorylate MAP2K dimer - Homo sapiens
[Reaction:R-HSA-9656214] MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants - Homo sapiens
[Reaction:R-HSA-9656209] Dissociation of RAS:RAF1 mutant complex - Homo sapiens

isInDisease true

isInferred false

literatureReference

maxDepth 2

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Signaling by RAF1 mutants

normalPathway [Pathway:R-HSA-5673001] RAF/MAP kinase cascade

releaseDate 2020年06月10日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020年05月04日

schemaClass Pathway

species

[Species:48887] Homo sapiens

stId R-HSA-9656223

summation

[Summation:9655957] RAF1, also known as CRAF, is mutated in a number of germline...

Referrals

(hasEvent)

[Pathway:R-HSA-6802957] Oncogenic MAPK signaling

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