Reactome Pathway Database

Schema > Reaction > Entries

Dissociation of RAS:RAF1 mutant complex Show undefined attributes

authored

[InstanceEdit:9664643] Rothfels, Karen, 2019年10月25日

category dissociation

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:9656210] Rothfels, Karen, 2019年07月27日

crossReference

dbId 9656209

disease

displayName Dissociation of RAS:RAF1 mutant complex

edited

[InstanceEdit:9690121] Rothfels, Karen, 2020年05月26日

entityFunctionalStatus

[EntityFunctionalStatus:9656200] gain_of_function of activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]

eventOf

[Pathway:R-HSA-9656223] Signaling by RAF1 mutants - Homo sapiens

input

[Complex:R-HSA-9656185] activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Dissociation of RAS:RAF1 mutant complex

normalReaction [Reaction:R-HSA-5672980] Dissociation of RAS:RAF complex

output

precedingEvent

[Reaction:R-HSA-9656214] MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants - Homo sapiens

releaseDate 2020年06月10日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020年05月04日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9656209

summation

[Summation:9655943] After phosphorylation of MAPKs by complexes containing RAF1 ...

Referrals

(hasEvent)

[Pathway:R-HSA-9656223] Signaling by RAF1 mutants

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