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Targeting RAS-ERK signalling in cancer: promises and challenges Show undefined attributes

author

[Person:6790421] Samatar, AA
[Person:6790389] Poulikakos, PI

created [InstanceEdit:6790419] Rothfels, Karen, 2015年08月10日

dbId 6790420

displayName Targeting RAS-ERK signalling in cancer: promises and challenges

journal Nat Rev Drug Discov

pages 928-42

pubMedIdentifier 25435214

schemaClass LiteratureReference

title Targeting RAS-ERK signalling in cancer: promises and challenges

url http://www.ncbi.nlm.nih.gov/pubmed/25435214

volume 13

year 2014

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(literatureReference)

[Pathway:R-HSA-6802957] Oncogenic MAPK signaling
[Pathway:R-HSA-9656223] Signaling by RAF1 mutants
[Reaction:R-HSA-9656213] RAF1 mutants show enhanced heterodimerization with BRAF
[Pathway:R-HSA-6802955] Paradoxical activation of RAF signaling by kinase inactive BRAF
[Reaction:R-HSA-6802943] RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks
[Reaction:R-HSA-6802942] RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs
[Reaction:R-HSA-6802941] RAF is paradoxically phosphorylated downstream of kinase-inactive RAF
[Reaction:R-HSA-8936731] Inactive BRAF mutants:mutant RAS:GTP bind RAF1
[Reaction:R-HSA-6802937] Inactive BRAF mutants bind mutant RAS:GTP
[Reaction:R-HSA-6802918] Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants
[Pathway:R-HSA-9652169] Signaling by MAP2K mutants
[Reaction:R-HSA-9652165] MAP2K mutants constitutively phosphorylate MAPKs
[Reaction:R-HSA-6802916] RAF is phosphorylated downstream of moderate kinase activity BRAF mutants
[Pathway:R-HSA-6802948] Signaling by high-kinase activity BRAF mutants
[Pathway:R-HSA-9652817] Signaling by MAPK mutants
[Reaction:R-HSA-6802924] RAF is phosphorylated downstream of oncogenic RAS
[Pathway:R-HSA-9649913] RAS GTPase cycle mutants
[Reaction:R-HSA-9657608] Single mechanism MAPK inhibitors bind phosphorylated MAPK
[Reaction:R-HSA-9657603] Dual mechanism MAPK inhibitors bind MAPKs
[Reaction:R-HSA-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks
[Reaction:R-HSA-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks

(author)

[Person:6790389] Poulikakos, PI
[Person:6790421] Samatar, AA

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Targeting RAS-ERK signalling in cancer: promises and challenges Show undefined attributes

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