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Schema
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Reaction
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Entries
RAF is phosphorylated downstream of oncogenic RAS
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authored
[InstanceEdit:5693873] Rothfels, Karen, 2015年05月18日
catalystActivity
[CatalystActivity:5672970] protein serine/threonine/tyrosine kinase activity of RAF activating kinases [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:6802923] Rothfels, Karen, 2015年10月02日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
6802924
disease
[Disease:1500689] cancer
displayName
RAF is phosphorylated downstream of oncogenic RAS
edited
[InstanceEdit:5693873] Rothfels, Karen, 2015年05月18日
entityFunctionalStatus
[EntityFunctionalStatus:6802864] gain_of_function of RAS mutants:GTP:RAF homo/heterodimer [plasma membrane]
eventOf
[Pathway:R-HSA-9649948] Signaling downstream of RAS mutants - Homo sapiens
followingEvent
[Reaction:R-HSA-6802925] Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs - Homo sapiens
input
4 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-6802611] RAS mutants:GTP:RAF homo/heterodimer [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:5672524] Regulation and role of Raf-1/B-Raf heterodimerization
[LiteratureReference:6790348] In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling
[LiteratureReference:5672291] Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
[LiteratureReference:6790250] C-Raf is required for the initiation of lung cancer by K-Ras(G12D)
[LiteratureReference:6790390] RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
[LiteratureReference:5672195] Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
[LiteratureReference:6790314] Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling
[LiteratureReference:6790420] Targeting RAS-ERK signalling in cancer: promises and challenges
[LiteratureReference:6790435] Tumor adaptation and resistance to RAF inhibitors
[LiteratureReference:5672425] Active Ras induces heterodimerization of cRaf and BRaf
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
RAF is phosphorylated downstream of oncogenic RAS
normalReaction
[Reaction:R-HSA-5672969] Phosphorylation of RAF
output
4 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-6802617] RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane]
precedingEvent
[Reaction:R-HSA-6802908] RAS mutants bind inactive RAF - Homo sapiens
releaseDate
2016年09月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8933498] Stephens, Robert M, 2016年08月05日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-6802924
summation
[Summation:6802212] In many cancer types, RAF1 (also known as CRAF) appears to b...
Referrals
(hasEvent)
[Pathway:R-HSA-9649948] Signaling downstream of RAS mutants
(precedingEvent)
[Reaction:R-HSA-6802925] Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs
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