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Signaling downstream of RAS mutants Show undefined attributes

authored

[InstanceEdit:5693873] Rothfels, Karen, 2015年05月18日

created [InstanceEdit:9649947] Rothfels, Karen, 2019年06月19日

crossReference

dbId 9649948

disease

[Disease:1500689] cancer

displayName Signaling downstream of RAS mutants

eventOf

[Pathway:R-HSA-6802949] Signaling by RAS mutants - Homo sapiens

hasDiagram true

hasEHLD false

hasEvent

[Reaction:R-HSA-6802908] RAS mutants bind inactive RAF - Homo sapiens
[BlackBoxEvent:R-HSA-6803240] Homo- or heterodimerization of RAF downstream of mutant RAS - Homo sapiens
[Reaction:R-HSA-6802924] RAF is phosphorylated downstream of oncogenic RAS - Homo sapiens
[Reaction:R-HSA-6802925] Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs - Homo sapiens
[Reaction:R-HSA-6802926] Mutant RAS:p-RAF complexes phosphorylate MAP2Ks - Homo sapiens
[Reaction:R-HSA-6802922] Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS - Homo sapiens
[Reaction:R-HSA-6803233] Dissociation of oncogenic RAS:RAF complex - Homo sapiens

isInDisease true

isInferred false

literatureReference

maxDepth 2

modified [InstanceEdit:12757879] Weiser, Joel, 2025年08月05日

name

Signaling downstream of RAS mutants

normalPathway [Pathway:R-HSA-5673001] RAF/MAP kinase cascade

releaseDate 2016年09月19日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:8933498] Stephens, Robert M, 2016年08月05日

schemaClass Pathway

species

[Species:48887] Homo sapiens

stId R-HSA-9649948

summation

[Summation:9651077] Disease-causing mutations in RAS favour the active RAS:GTP b...

Referrals

(hasEvent)

[Pathway:R-HSA-6802949] Signaling by RAS mutants

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